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News Development and Benefits of Intestinal Gel LECIG for Patients with Parkinson's Disease

Patients with advanced Parkinson's disease, for whom the current regimen of orally and transdermally administered medications is insufficient for symptom relief, now have a new treatment option. It involves the continuous administration of an intestinal gel that combines three effective antiparkinsonian drugs.

Source: Parkinson's Disease 10. 3. 2023

News Untreated Bleeding in Hemophilia A –⁠ An Underestimated Problem? To What Extent?

How common is bleeding in hemophilia A that ultimately goes untreated? This was the focus of a recent study, the results of which were published in the journal Research and Practice in Thrombosis and Hemostasis.

Source: Hemophilia 27. 11. 2023

News Can the Treatment of Hypertension Prevent Recurrence of Atrial Fibrillation?

Atrial fibrillation (Afib) is the most common serious heart rhythm disorder and is responsible for a significant portion of deaths in the population. Hypertension is the most common and potentially modifiable risk factor for Afib. A newly published meta-analysis compares the effect of angiotensin receptor antagonism and calcium channel blockade on Afib recurrence in patients with hypertension and Afib.

Source: Sartans in the Treatment of Hypertension 3. 12. 2021

News Meta-analysis of the efficacy and safety of dupilumab in the treatment of atopic dermatitis in children and adults

Moderate to severe atopic dermatitis (AD) is accompanied by strong inflammatory processes that can occur anywhere on the skin, intense itching, and pain. The biologic dupilumab is a promising molecule for the treatment of severe forms of this condition –⁠ results from a recently published meta-analysis indicate that this therapy is not only effective but also well-tolerated by patients.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 13. 6. 2023

News Dupilumab in the Treatment of Adolescent Patients with Severe and Refractory Atopic Dermatitis

An open multicenter study evaluating dupilumab in the treatment of moderate to severe atopic dermatitis in adolescents confirmed its long-term efficacy and safety in this age group. In addition to its results, we also summarize information on dosing and reimbursement conditions in the Czech Republic for the age group 12-18 years.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 1. 12. 2020

News The safety of dupilumab allows treatment of atopic dermatitis without routine laboratory monitoring

The first comprehensive analysis of laboratory data from 3 clinical trials with dupilumab assessed the incidence of clinically significant changes in hematological or biochemical parameters in patients with moderate to severe atopic dermatitis.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 14. 12. 2020

News Risk of Subsequent Fractures in Postmenopausal Women After Initial Fracture

Osteoporosis is associated with an increased risk of fractures. The prospective analysis presented below examined the risk of subsequent fractures in postmenopausal women after an initial fracture depending on its location.

Source: Osteoporosis – Trends in Sequential Therapy 4. 9. 2023

News Prediabetes as a Risk Factor for Overall Mortality and Development of CVD

Prediabetes represents a glucose metabolism disorder with a high risk of developing diabetes. According to the expert panel of the American Diabetes Association (ADA), this risk is up to 70%. A recently published meta-analysis confirms that prediabetes is a significant risk factor for mortality and the development of cardiovascular (CV) diseases not only in the general population but also in patients with known CV disease, and its treatment should therefore be part of cardiovascular prevention.

Source: Modern Treatment of Diabetes 16. 9. 2022

News New Treatment Options for Hemophilia Come with Discussions on Important Issues

The organizing committee of this year's virtual congress of the European Association for Haemophilia and Allied Disorders (EAHAD 2021) promised in the opening speech a "showcase of the latest innovations and advances in the field of hemophilia and bleeding disorders." The program naturally included discussions on current research findings and practical experiences. Topics included the potential role of coagulation factor VIII even with non-factor therapies and the importance of monitoring the success of new therapeutic approaches.

Source: Quality Life Even with Hemophilia 24. 3. 2021

Články časopisu Analysis of the results of radiotherapy and chemoradiotherapy on the background of immunotherapy of patients with cancer of the oral cavity and oropharynx

Author of the article: H. A. Hirna Source: Klinická onkologie | 3/2022 17. 6. 2022

News Treatment of Schizophrenia in a Patient at Risk of Developing Metabolic Syndrome –⁠ Interactive Case Study

A 34-year-old man has been under psychiatric care for 3 years due to a psychotic disorder. Three years ago, he had his first short hospitalization due to marked paranoid symptoms: feelings of being watched, eavesdropping, auditory hallucinations of an imperative nature...

Source: Modern Treatment of Schizophrenia 17. 7. 2023

News Psychotic patient with high cardiometabolic risk –⁠ interactive case report

The following case report describes the treatment of a patient diagnosed with paranoid schizophrenia following a relapse of the disease. During therapy, complications arose in the form of weight gain, deterioration of metabolic parameters, sedation, and sexual dysfunction. Additionally, the patient is not capable of adhering to the principles of a healthy lifestyle. Is it possible to find an optimal treatment approach even in such a case?

Source: Modern Treatment of Schizophrenia 9. 12. 2021

News Familial Hypercholesterolemia and COVID-19: Connections and Risks

Patients with familial hypercholesterolemia (FH) likely have a higher risk of COVID-19 complications both in the acute phase of the infection and for a relatively long period after its occurrence.

Source: Hypercholesterolemia 18. 3. 2021

Články časopisu Hereditary angioedema –⁠ neglected diagnosis

Author of the article: P. Králíčková, E. Burešová, T. Freiberger, I. Tachecí Source: Vnitřní lékařství | 9/2010 7. 9. 2010

News Metamizole in the Treatment of Acute Postoperative Pain

In many countries, metamizole is considered a first-choice non-opioid analgesic. The analysis presented below, published in the Cochrane Database of Systematic Reviews, examined the efficacy and safety of metamizole in the treatment of acute postoperative pain.

Source: Analgesia 25. 5. 2021