Search results: (10000)
News Dabigatran as Effective Prevention of VTE Recurrence Also in Patients with Thrombophilia
With increasing positive experience with direct oral anticoagulants, the question arises of how these drugs work in different groups of patients − for example, in those who have a congenital or acquired thrombophilic state.
News Safety and Efficacy of Different Antithrombotic Regimens in Patients with Atrial Fibrillation after Percutaneous Coronary Intervention
Patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or after percutaneous coronary intervention (PCI) require antithrombotic therapy for the prevention of atherothrombosis, stent thrombosis, and cerebrovascular stroke (CVS). The meta-analysis presented below attempted to clarify which antithrombotic regimen is most suitable in terms of safety and efficacy for these patients.
News Trazodone as a Multimodal and Multifunctional Antidepressant
Substances with multiple therapeutic effects, often depending on the dose, can be described as multifunctional. In low doses, trazodone has hypnotic effects, while its effective antidepressant action is evident at higher doses. This can be more frequently utilized now thanks to a modified-release formulation, which has the potential to improve the tolerability of antidepressant doses of trazodone.
News Prognostic Significance of Subclinical Joint Changes on MRI in Hemophilia
Experience shows that monitoring joint changes, especially subclinical ones, is very necessary in the care of hemophiliacs. Unfortunately, conventional X-rays cannot detect early changes in joints. Magnetic resonance imaging (MRI) plays an indispensable role in detecting these changes.
News Immunotolerance is still the goal of management of hemophilia A with inhibitor in the era of non-factor therapy
New molecules in hemophilia therapy have raised many questions, including regarding the significance and need for immune tolerance induction (ITI). Interesting conclusions from the FIT (Future of Immunotolerance Treatment) expert panel discussion on the future of ITI, its form, and indication were published in July 2019.
News Prognostic Significance of Lymphopenia for Stratification of Patients with Follicular Lymphoma
The therapy of follicular lymphoma (FL) is guided by several prognostic indices, such as the Follicular Lymphoma International Prognostic Index (FLIPI). The retrospective analysis of 736 patients with FL presented below introduces a prognostic model combining FLIPI and absolute lymphopenia into an integrated FLIPI-L index. Absolute lymphopenia is crucial for stratifying patient OS and the risk of transformation.
News Importance of pH in Care for Stoma Patients
Maintaining good quality peristomal skin and preventing complications related to the stoma site are integral parts of comprehensive care for patients with stomas. The pH of the skin also plays an important role in this issue, as it can significantly affect the condition of the skin, the development of complications, the quality of life of patients, and consequently impact the economic aspect of stoma care.
News Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer
The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance treatment of patients with newly diagnosed advanced ovarian, fallopian tube, or peritoneal cancer with BRCA 1/2 mutation leads to an improved prognosis for these patients.
News Safety and Tolerance of Metamizole in Postoperative Analgesia in Children
Due to the potential serious side effects of metamizole, the use of this drug in children is often a topic of discussion. Therefore, a prospective multicenter observational non-interventional post-marketing safety study aimed to evaluate the safety of using metamizole in children, with an emphasis on hemodynamic, anaphylactic, or respiratory reactions and agranulocytosis.
News Type of Pharmacological Thromboprophylaxis and Disease Stage as Risk Factors for Bleeding in Patients After Colorectal Cancer Surgery
Japanese authors of a study published last year in the World Journal of Surgical Oncology attempted to answer the question of whether the incidence of postoperative bleeding in patients undergoing elective surgery for colorectal cancer is associated with the type of pharmacological prophylaxis or the disease stage.
News Basic Information on the Spread and Course of COVID-19 Infection in China: What We Know So Far?
Currently, we are experiencing a worldwide outbreak of COVID-19 infection caused by the SARS-CoV-2 virus, with the first cases identified in December 2019 in Wuhan, China. As of March 18, 2020, according to WHO information, the virus has spread to six continents and a total of 179,111 people worldwide were infected with COVID-19, of whom 7,426 have died from the disease. Sharing transparent, valid, and relevant information is one of the cornerstones of the fight to mitigate the impact of this infection. Chinese authors recently published a summary of current knowledge on the epidemiology, clinical manifestations, diagnosis, treatment, and prevention of COVID-19, valid as of March 2, 2020, in the International Journal of Infectious Diseases.
News Impact of Body Mass Index on Survival and Treatment Outcomes of Metastatic Colorectal Cancer
A pooled analysis of 25 studies with patients in the first line of treatment for metastatic colorectal cancer (mCRC) evaluated the prognostic and predictive significance of body mass index (BMI). Until its publication in 2015, only the adverse impact of low and high BMI on outcomes in patients with early stages of colorectal cancer was known.
News Testing RAS Gene Mutations in Patients with Colorectal Cancer
Correct identification of the RAS oncogene variant is crucial for deciding the treatment of patients with colorectal cancer. Information on the prevalence of individual RAS gene mutations varies significantly in the literature, which may be due to different testing methods. The authors of the presented analysis focused on how the approach to testing RAS variants has evolved over time in Europe.
News Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children
Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi summarizes the possibilities and rationale for their use in this indication.
News L. reuteri DSM 17938 in Infant Nutrition and Its Impact on the Gut Microbiota of Infants Born by Cesarean Section
The work of the Swiss-Greek team published in the Journal of Pediatric Gastroenterology and Nutrition focused on comparing the effect of infant formula containing Lactobacillus reuteri DSM 17938 on the microbiota of children born by cesarean section or vaginal delivery.