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News Wound Treatment Without Pain? A Rinse Solution Can Help
Patients dealing with a healing wound may fear painful dressing changes. The wound bed is exposed and highly sensitive to pain due to damaged nerve endings. By using a rinse solution, however, we can eliminate the traumatic removal of the primary dressing, making the dressing change gentler for the patient. But which solutions are suitable for this purpose and which are not?
News Memantine, Acetylcholinesterase Inhibitors, and Their Combination in the Treatment of Alzheimer's Disease − Findings from Meta-Analyses
Is memantine, an acetylcholinesterase inhibitor (donepezil), or their combination more advantageous in the therapy of Alzheimer's disease? Two meta-analyses tried to answer this question, and we summarize their conclusions in the following article.
News Positive Effect of Pregabalin Not Only on Neuropathic Pain in Patients with Spinal Cord Injury
Spinal cord injury is often accompanied by painful conditions. A study published in the prestigious journal Neurology demonstrated that administering pregabalin to these patients can bring more than just pain relief.
News Alopecia Areata – Autoimmune Inflammatory Disease and a New Targeted Treatment Option
Alopecia areata (AA) is one of the non-scarring focal alopecias. It is an autoimmune disease of the hair follicle, the etiopathogenesis of which is not entirely understood. At the hair root, a lymphocytic inflammatory infiltrate develops, resulting in follicle miniaturization and the growth of a thin dystrophic hair. Recently, however, a new strategy for the treatment of AA has emerged, focusing on reducing inflammation of the hair follicle by inhibiting Janus kinases (JAK). This is the first therapeutic modality officially approved for this indication.
News Side Effects of Metformin: It's Not Just a Nocebo Effect?
If we were to name medications that have the greatest significance from a population standpoint, metformin would certainly be at the top of the list. We have known it for over fifty years and know a lot about it, including its negatives. But is it time to replace it with new drugs? Or is it worth staying with it?
News Fixed Combination of Candesartan/Amlodipine in the Treatment of Arterial Hypertension
Arterial hypertension is a significant cardiovascular risk factor. A variety of antihypertensives are used in therapy, both in monotherapy and combination treatment. Often, it is necessary to treat patients with a combination of multiple antihypertensives to achieve satisfactory blood pressure values. A popular fixed combination with a favorable pharmacodynamic and pharmacokinetic profile is the combination of candesartan and amlodipine, whose effects have been verified by numerous extensive clinical studies.
News Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia
Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the potential of its multimodal effect sometimes remains untapped.