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News Parenteral Nutrition in Oncological Patients in Current ESPEN Recommendations

The current guidelines of the European Society for Clinical Nutrition and Metabolism (ESPEN) address nutritional care in oncological patients −⁠ current knowledge is summarized in a total of 43 recommendations, from which we select some key points, focusing primarily on parenteral nutrition in these patients.

Source: Parenteral Nutrition 15. 3. 2022

News Potential of Aloe to Reduce Severity of Symptoms in Patients with IBS −⁠ What Emerged from the Analysis of Fecal Microflora and Metabolite Profiles?

Current treatment options for irritable bowel syndrome (IBS −⁠ irritable bowel syndrome) are relatively limited. This increases interest in complementary and alternative therapy options with plant preparations. One modality used to alleviate IBS symptoms is Aloe barbadensis Mill. The aim of a clinical study by Swedish researchers was to assess the effect of aloe on IBS symptoms compared to a control treatment with inulin.

Source: Irritable Bowel Syndrome 12. 11. 2022

Články časopisu POSTTRAUMATIC INSTABILITY OF THE KNEE JOINT IN PARTIAL ANTERIOR CRUCIATE LIGAMENT LESION. CONSERVATIVE VERSUS OPERATIVE TREATMENT PROCEDURE

Author of the article: Pavel Holeka, Zdeněk Koreček, Jan Vanáč, Vladimír Ninger Source: Úrazová chirurgie | 2/2016 18. 6. 2016

Články časopisu Type 2 diabetes mellitus and bone quality

Author of the article: MUDr. Raška Ivan, Ph.D. Source: Clinical Osteology | 3/2018 14. 5. 2019

News Which Dietary Recommendations Actually Work for Irritable Bowel Syndrome?

Food is both a trigger for symptoms and a treatment tool for individuals with irritable bowel syndrome (IBS). A 2021 review summarizes the results of the latest research on the effectiveness of dietary measures for IBS and the evidence of which measures are truly beneficial. A positive impact was found for general healthy eating recommendations, soluble fiber supplementation, a low short-chain carbohydrate diet, and probiotic administration.

Source: Irritable Bowel Syndrome 13. 6. 2022

News Trazodone with Extended Release Improves Patient Compliance

Since 2015, the antidepressant trazodone is available in the Czech Republic in a controlled-release formulation. A sufficiently high plasma level for 24 hours without fluctuation allows for administration only once a day, while eliminating side effects.

Source: Depression and Anxiety 20. 5. 2020

Články časopisu Has everything really been discovered about SGLT2 inhibitors?

Author of the article: Daša Skripová Source: Diabetes a obezita | 38/2019 8. 2. 2020

News How to Dose Beta-Blockers After Myocardial Infarction?

In patients after myocardial infarction (MI), there is a frequent administration of too low doses of beta-blockers (BB) and rare upward titration of their dose after discharge from the hospital. The SWEDEHEART study investigated to what extent the BB dose actually affects 5-year cardiovascular (CV) outcomes, and data from the American registry allowed a focus on mortality after MI depending on BB dosing.

Source: Cardiovascular Continuum 23. 2. 2022

News Metamizole in Pain Therapy in the General Practitioner and Pediatric Office

Metamizole is a pyrazole analgesic-antipyretic with spasmolytic effects, indicated for the treatment of post-traumatic or postoperative pain, visceral colic, cancer pain, and high fever unresponsive to other treatments. The advantage of this drug is its good tolerance without serious adverse effects on the gastrointestinal system, no impact on platelet aggregation, and usability in adults and children of all ages.

Source: Updates in Pain Treatment 30. 3. 2023

News Aloe vera Extract in the Therapy of Irritable Bowel Syndrome

The therapy options for irritable bowel syndrome are relatively limited, thus complementary and alternative treatments besides conventional therapy are applied. Many patients report that using Aloe vera extract helps reduce their disease symptoms, although there is a lack of valid evidence from clinical studies. The pilot study presented below focused on evaluating the efficacy of Aloe vera extract compared to placebo in several dozen patients with irritable bowel syndrome.

Source: Irritable Bowel Syndrome 12. 10. 2022

News MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life

Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them and how has it proven itself in real practice? MUDr. Jana Zárubová from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague describes.

Source: Quick aid for acute convulsive seizures in children and adolescents 21. 2. 2024

News Treatment of Schizophrenia in Light of New Findings

"Mental disorders constitute a significant burden on society," began Assoc. Prof. MUDr. Martin Anders, Ph.D., head of the Psychiatric Clinic at the First Faculty of Medicine, Charles University and General University Hospital in Prague, during his presentation at the psychiatric symposium titled "A Chance for a Better Life with Schizophrenia Diagnosis," held on October 18, 2021, in Prague. His lecture focused on key issues in the treatment of schizophrenia, as well as on one of the recently registered antipsychotics—lurasidone.

Source: Modern Treatment of Schizophrenia 14. 12. 2021

News The Anti-inflammatory and Renoprotective Effect of Candesartan May Be Independent of the AT1 Receptor

Candesartan belongs to the blockers of AT1 receptors (AT1R) for angiotensin II coupled with G protein. The authors of the presented study found that the anti-inflammatory and renoprotective effect of candesartan persists even when the receptor is completely blocked. The aim of the further study was to clarify this mechanism -⁠ independent of AT1R.

Source: Sartans in the Treatment of Hypertension 12. 8. 2021

News Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients

In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.

Source: Thyroid Disorders 8. 6. 2022

News Eletriptan as an effective and safe drug in acute migraine therapy

In the pharmacotherapy of acute migraine attacks, a pharmacologically diverse group of triptans is particularly used. The choice of the right antimigraine drug should be individualized, based on the intersection of the patient's nature of complaints and the pharmacological profile of the drug. The following text briefly summarizes the basic characteristics and profile of eletriptan.

Source: Treatment of Severe Migraine 20. 9. 2021