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News Long-term results of alpha-1-antitrypsin deficiency treatment – RAPID program
RAPID/RAPID Extension is the largest clinical program to date that has confirmed the benefit of alpha-1-antitrypsin inhibitor in the treatment of chronic obstructive pulmonary disease (COPD) associated with its deficiency.
News Spasmolytic Effect of Metamizole
A study aimed at clarifying the mechanism of action of metamizole suggested that the clinically proven effect of this analgesic on colicky pain originating from the biliary tract could be due to agonism on β2-adrenergic receptors in the smooth muscle of the bile ducts.
News Insufficient dosing of enoxaparin is common in patients post-orthopedic surgery and increases the risk of thromboembolic disease
Orthopedic and traumatological procedures involving the pelvis and lower limbs are associated with a significant increase in the risk of thromboembolic disease. Therefore, prophylaxis with anticoagulants is recommended in the perioperative and postoperative period for these procedures. The most commonly administered anticoagulants are low molecular weight heparins, among which enoxaparin is included. A recently published study by authors from the University of Utah focused on insufficient dosing of enoxaparin and its impact on the development of thromboembolic disease within 90 days following the procedure.
News Most Common Dermatoses Around the Stoma
The incidence of stomal complications ranges between 20 and 70%. One type of complication is dermatoses affecting the peristomal skin. These issues can occur in the early postoperative period, but also several years later.
News Trazodone with Extended Release Improves Patient Compliance
Since 2015, the antidepressant trazodone is available in the Czech Republic in a controlled-release formulation. A sufficiently high plasma level for 24 hours without fluctuation allows for administration only once a day, while eliminating side effects.
News ESC 2022: Heart Failure with Preserved Ejection Fraction as an Underdiagnosed Problem: How to Increase Its Detection in Everyday Practice?
During this year's European Society of Cardiology Congress (ESC 2022), alarming information was shared, indicating that heart failure with preserved ejection fraction of the left ventricle (HFpEF) is likely underdiagnosed in clinical practice, necessitating improved identification and detection of patients with this condition. One of the symposiums addressed not only the reasons why many patients with HFpEF are misdiagnosed.
News Classification and Management of Chronic Wounds
Chronic wounds are common comorbidities that increase the morbidity and mortality of patients. Common types of chronic wounds on the lower extremities include arterial, venous, and diabetic ulcers, as well as pressure ulcers. Despite their frequent occurrence, they are often poorly treated. In addition to diagnosing the etiology of chronic wounds and specific therapies, moist wound healing plays a crucial role in the treatment, such as the application of hydrocolloids and hydrogels.
News Morning Myopic Shift and Glare in Patients with Advanced Fuchs Endothelial Corneal Dystrophy
A newly published study by a German team analyzes the morning and afternoon differences in various parameters in patients with Fuchs endothelial corneal dystrophy to determine which of them contribute to subjective visual difficulties in the morning.
News AI Could Transform Cancer Treatment by Precisely Identifying Tumor Cells
A new artificial intelligence tool called AAnet, developed and tested by researchers led by the Garvan Institute of Medical Research, focuses on the cellular diversity within individual tumors. Deeper understanding of the different types of cells present in tumors could pave the way for therapies more accurately tailored to individual patients.