The first oral proteasome inhibitor in the treatment of relapsed/refractory multiple myeloma
Authors:
H. Plonková; T. Jelínek; L. Szeligová; R. Hájek
Authors‘ workplace:
Lékařská fakulta, Ostravská univerzita, Ostrava
; Klinika hematoonkologie, Fakultní nemocnice Ostrava
Published in:
Transfuze Hematol. dnes,23, 2017, No. 4, p. 199-209.
Category:
Overview
Ixazomib is the first and only oral proteasome inhibitor, indicated for the treatment of multiple myeloma in combination with lenalidomide and dexamethasone in patients who have received at least one prior therapy. The approval is based on the results of the randomized, double-blind, placebo-controlled phase III TOURMALINE-MM1 trial that demonstrated statistically significant improvement in progression-free survival in patients treated with the all-oral triplet combination of ixazomib plus lenalidomide and dexamethasone compared to patients in the lenalidomide and dexamethasone arm (20.6 months vs 14.7 months in the control group; hazard ratio 0.74; p = 0.01; median follow-up 14.7 months). The addition of ixazomib to a regimen of lenalidomide and dexamethasone is generally well tolerated with no negative impact on patient-reported quality of life. In this review, we highlight the efficacy, safety, pharmacokinetics and patient-reported quality of life data of ixazomib. We focus on the role of ixazomib in the treatment of patients with relapsed/refractory multiple myeloma including patients with high-risk cytogenetic features as well as heavily pretreated patients.
Key words:
ixazomib – proteasome inhibitor – multiple myeloma
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Transfusion and Haematology Today
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