Authors: L. Šmardová 1; Martin Huser 2; Z. Král 1; I. Crha 2; I. Vášová 1; B. Wagnerová 1; J. Mayer 1; J. Vorlíček 1 Authors‘ workplace: Interní hematoonkologická klinika, FN Brno 1; Gynekologicko-porodnická klinika, FN Brno 2 Published in: Transfuze Hematol. dnes,11, 2005, No. 4, p. 162-169. Category: Comprehensive Reports, Original Papers, Case Reports
The most serious problem resulting from the chemotherapy of patients with Hodgkin lymphoma represents progression into the late effects of treatment, including gonadal toxicity. Consequently authors present here summary of risks regarding early ovarial failure in women and impairment of testicular function in men that are treated by chemotherapy and radiotherapy. The authors mentioned their own experiences too. Current means of preservation of reproductive status of young patients undergoing cytostatic treatment are summarized. Particularly means of pharmacological preservation of ovarial functions by administrating gonadotropin-releasing hormone analogues as well as methods of assisted reproduction.
Key words: Hodgkin lymphoma, gonadal toxicity, early ovarial failure, gonadotropin-releasing hormone analogues, sperm kryoconzervation, assisted reproduction
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