Vliv ultrazvuku na účinnost fotodynamické terapie – in vitro studie
Authors:
Klára Pížová 1,2; Kateřina Tománková 1; Kateřina Langová 1; Adéla Hanáková 1,2; Hana Lenobelová 1; Hana Zapletalová 1; Jakub Malohlava 1,2; Svatopluk Binder 1; Robert Bajgar 1,2; Jaromír Vachutka 1; Ladislav Doležal 1; Hana Kolářová 1
Authors‘ workplace:
Ústav lékařské biofyziky, Lékařská fakulta, Univerzita Palackého, Olomouc, ČR
1; Ústav molekulární a translační medicíny, Lékařská fakulta, Univerzita Palackého, Olomouc, ČR
2
Published in:
Lékař a technika - Clinician and Technology No. 4, 2012, 42, 18-22
Overview
Photodynamic therapy (PDT) belongs in perspective modalities of cancer treatment. It is based on the tumour-selective accumulation of a photosensitizer followed by irradiation with light of a specific wavelength. PDT is widely developed nowadays due to its high specificity and selectivity along with absence of the unadvisable side-effects. Sonodynamic therapy (SDT) exploits ultrasound to induce cytotoxic effect of sensitizer. In our study we tested the possibility of combination of this therapies and icrease of efficiency. Our results suggest that irradiation in combination with application of therapeutic ultrasound increases production of reactive oxygen species and reduces viability of tumour MCF7 cells, compared to irradiation of ZnTPPS4 only, especially in the case of higher therapeutic doses. In the future, the combination of PDT and SDT can bring a new treatment modality for malignant and also nonmalignant diseases.
Keywords:
photosensitizer, photodynamic therapy, sonodynamic therapy, porphyrine derivative
Sources
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