#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Intra-Articular Healing and Graft-to-Bone Incorporation after Arthroscopic Anterior Cruciate Ligament Reconstruction


Authors: D. Smékal 1;  I. Hanzlíková 1;  D. Žiak 2,3;  J. Opavský 1
Authors‘ workplace: Katedra fyzioterapie, Fakulta tělesné kultury, Olomouc vedoucí prof. MUDr. J. Opavský, CSc. 1;  Vzdělávací a výzkumný institut AGEL, o. p. s. – pobočka Ostrava-Vítkovice, CGB laboratoř a. s., Ostrava ředitelka RNDr. M. Uvírová 2;  Ústav patologie, Fakultní nemocnice Ostrava přednosta doc. MUDr. J. Dvořáčková, Ph. D. 3
Published in: Rehabil. fyz. Lék., 21, 2014, No. 3, pp. 114-123.
Category: Original Papers

Overview

The anterior cruciate ligament is the most frequently damaged ligament in the knee. A result of this damage is the instability of the knee joint usually solved by operation, with the use of the patellar or hamstring tendon graft. A graft has to undergo three phases of intra-articular healing and graft-to-bone incorporation after surgical reconstruction. During the healing process the graft changes its biological and mechanical properties which are summarized in this article. The understanding of the remodeling process and incorporation to the bone, depending on the type of graft, fixation technique and graft tensioning, is important for the improvement of surgical technique and rehabilitation to achieve the full restoration of the graft.

Keywords:
anterior cruciate ligament, intra-articular healing, graft-to-bone incorporation


Sources

1. ABE, S., KUROSAKA, M., IGUCHI, T., YOSHIYA, S., HIROHATA, K.: Light and electron microscopic study of remodeling and maturation process in autogenous graft for anterior cruciate ligament reconstruction [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 9, 1993, 3, s. 394-405.

2. ABRAMOWITCH, S. D., PAPAGEORGIOU, C. D., WITHROW, J. D., GILLBERT, T. W., WOO, S. Y.: The effect of initial graft tension on the biomechanical properties of a healing ACL replacement graft: A study in goats [Abstract]. Journal of Orthopaedic Research, 21, 2003, 4, s. 708-715.

3. AHN, J. H., LEE, S. H., CHOI, S. H., LIM, T. K.: Magnetic resonance imaging evaluation of anterior cruciate ligament reconstruction using quadrupled hamstring tendon autografts comparison of remnant bundle preservation and standard technique [Abstract]. The American Journal of Sports Medicine, 38, 2010, 9, s. 1768-1777.

4. AMIEL, D., KLEINER, J. B., ROUX, R. D., HARWOOD, F. L., AKESON, W. H.: The phenomenon of “ligamentization”: Anterior cruciate ligament reconstruction with autogenous patellar tendon [Abstract]. Journal of Orthopaedic Research, 4, 1986, 2, s. 162-172.

5. ANDERSON, K., SENEVIRATNE, A. M., IZAWA, K., ATKINSON, B. L., POTTER, H. G., RODEO, S. A.: Augmentation of tendon healing in an intraarticular bone tunnel with use of a bone growth factor [Abstract]. The American Journal of Sports Medicine, 29, 2001, 6, s. 689-698.

6. BAXTER, F. R., BACH, J. S., DETREZ, F., CANTOUMET, S., CORTÉ, L., CHERKAOUI, M., KU, D. N.: Augmentation of bone tunnel healing in anterior cruciate ligament grafts: Application of calcium phosphates and other materials. Journal of Tissue Engineering, 1, 2010, 1, s. 4061-4073.

7. BEDI, A., KOVACEVIC, D., FOX, A. J., IMHAUSER, C. W., STASIAK, M., PACKER, J., BROPHY, R. H., XIANG-HUA, D., RODEO, S. A.: Effect of early and delayed mechanical loading on tendon-to-bone healing after anterior cruciate ligament reconstruction. The Journal of Bone & Joint Surgery, 92, 2010, 14, s. 2387-2401.

8. DONG, Y., ZHANG, Q., LI, Y., JIANG, J., CHEN, S.: Enhancement of tendon-bone healing for anterior cruciate ligament (ACL) reconstruction using bone marrow-derived mesenchymal stem cells infected with BMP-2. International Journal of Molecular Sciences, 13, 2012, 10, s. 13605-13620.

9. EKDAHL, M., WANG, J. H.-C., RONGA M., FU, F. H.: Graft healing in anterior cruciate ligament reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy, 16, 2008, 10, s. 935-947.

10. FALCONIERO, R. P., DISTEFANO, V. J., COOK, T. M.: Revascularization and ligamentization of autogenous anterior cruciate ligament grafts in humans [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 14, 1998, 2, s. 197-205.

11. FISHER, M. B., LIANG, R., JUNG, H. J., KIM, K. E., ZAMARRA, G., ALMARZA, A. J., WOO, S. L.: Potential of healing a transected anterior cruciate ligament with genetically modified extracellular matrix bioscaffolds in a goat model. Knee Surgery, Sports Traumatology, Arthroscopy, 20, 2012, 7, s. 1357-1365.

12. FU, S. C., CHENG, W. H., CHEUK, Y. C., MOK, T. Y., ROLF, C. G., YUNG, S. H., CHAN, K. M.: Effect of graft tensioning on mechanical restoration in a rat model of anterior cruciate ligament reconstruction using free tendon graft [Abstract]. Knee Surgery, Sports Traumatology, Arthroscopy, 21, 2012, 5, s. 1226-1233.

13. GORADIA, V. K., ROCHAT, M. C., GRANA, W. A., ROHRER, M. D., PRASAD, H. S.: Tendon-to-bone healing of a semitendinosus tendon autograft used for ACL reconstruction in a sheep model [Abstract]. The American Journal of Knee Surgery, 13, 2000, 3, s. 143-151.

14. GRANA, W. A., EGLE, D. M., MAHNKEN, R., GOODHART, C. W.: An analysis of autograft fixation after anterior cruciate ligament reconstruction in a rabbit model [Abstract]. The American Journal of Sports Medicine, 22, 1994, 3, s. 344-351.

15. HUNT, P., REHM, O., WEILER, A.: Soft tissue graft interference fit fixation: Observations on graft insertion site healing and tunnel remodeling 2 years after ACL reconstruction in sheep. Knee Surgery, Sports Traumatology, Arthroscopy, 14, 2006, 12, s. 1245-1251.

16. CHO, S., MUNETA, T., ITO, S., YAGISHITA, K., ICHINOSE, S.: Electron microscopic evaluation of two-bundle anatomically reconstructed anterior cruciate ligament graft. Journal of Orthopaedic Science, 9, 2004, 3, s. 296-301.

17. ISHIBASHI, Y., TOH, S., OKAMURA, Y., SASAKI, T., KUSUMI, T.: Graft incorporation within the tibial bone tunnel after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autograft. The American Journal of Sports Medicine, 29, 2001, 4, s. 473-479.

18. KLEINER, J. B., AMIEL, D., HARWOOD, F. L., AKESON, W. H.: Early histologic, metabolic, and vascular assessment of anterior cruciate ligament autografts [Abstract]. Journal of Orthopaedic Research, 7, 1989, 2, s. 235-242.

19. KURODA, R., KUROSAKA, M., YOSHIYA, S., MIZUNO, K.: Localization of growth factors in the reconstructed anterior cruciate ligament: Immunohistological study in dogs [Abstract]. Knee Surgery, Sports Traumatology, Arthroscopy, 8, 2000, 2, s. 120-126.

20. LIM, J. K., HUI, J., LI, L., THAMBYAH, A., GOH, J., LEE, E. H.: Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 20, 2004, 9, s. 899-910.

21. LUI, P. P. Y., HO, G., SHUM, W. T., LEE, Y. W., HO, P. Y., LO, W. N., LO, C. K.: Inferior tendon graft to bone tunnel healing at the tibia compared to that at the femur after anterior cruciate ligament reconstruction [Abstract]. Journal of Orthopaedic Science, 15, 2010, 3, s. 389-401.

22. MAGNUSSEN, R. A., LAWRENCE, J. T. R., WEST, R. L., TOTH, A. P., TAYLOR, D. C., GARRETT, W. E.: Graft size and patient age are predictors of early revision after anterior cruciate ligament reconstruction with hamstring autograft [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 28, 2012, 4, s. 526-531.

23. MAJIMA, T., YASUDA, K., TSUCHIDA, T., TANAKA, K., MIYAKAWA, K., MINAMI, A., HAYASHI, K.: Stress shielding of patellar tendon: Effect on small-diameter collagen fibrils in a rabbit model. Journal of Orthopaedic Science, 8, 2003, 6, s. 836-841.

24. MAJIMA, T., YASUDA, K., YAMAMOTO, N., KANEDA, K., HAYASHI, K.: Deterioration of mechanical properties of the autograft in controlled stress-shielded augmentation procedures an experimental study with rabbit patellar tendon [Abstract]. The American Journal of Sports Medicine, 22, 1994, 6, s. 821-829.

25. MENETREY, J., LAUMONIER, T., GARAVAGLIA, G., HOFFMEYER, P., FRITSCHY, D., GABBIANI, G., BOCHATON-PIALLAT, M. L.: α-smooth muscle actin and TGF-β receptor I expression in the healing rabbit medial collateral and anterior cruciate ligaments. Injury, 42, 2011, 8, s. 735-741.

26. MIFUNE, Y., MATSUMOTO, T., TAKAYAMA, K., TERADA, S., SEKIYA, N., KURODA, R., HUARD, J.: Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction. Biomaterials, 34, 2013, 22, s. 5476-5487.

27. NEBELUNG, W., BECKER, R., URBACH, D., RÖPKE, M., ROESSNER, A.: Histological findings of tendon-bone healing following anterior cruciate ligament reconstruction with hamstring grafts. Archives of Orthopaedic and Trauma Surgery, 123, 2003, 4, s. 158-163.

28. NG, G. Y., OAKES, B. W., DEACON, O. W., MCLEAN, I. D., EYRE, D. R.: Long-term study of the biochemistry and biomechanics of anterior cruciate ligament-patellar tendon autografts in goats [Abstract]. Journal of Orthopaedic Research, 14, 1996, 6, s. 851-856.

29. NTOULIA, A., PAPADOPOULOU, F., ZAMPELI, F., RISTANIS, S., ARGVROPOULOU, M., GEORGOULIS, A.: Evaluation with contrast-enhanced magnetic resonance imaging of the anterior cruciate ligament graft during its healing process: A two-years prospective study [Abstract]. Skeletal Radiology, 42, 2013, 4, s. 541-552.

30. OHNO, K., YASUDA, K., YAMAMOTO, N., KANEDA, K. HAYASHI, K.: Effects of complete stress-shielding on the mechanical properties and histology of in situ frozen patellar tendon. Journal of Orthopaedic Research, 11, 1993, 4, s. 592-602.

31. PETERSEN, W., LAPRELL, H.: Insertion of autologous tendon grafts to the bone: A histological and immunohistochemical study of hamstring and patellar tendon grafts. Knee Surgery, Sports Traumatology, Arthroscopy, 8, 2000, 1, s. 26-31.

32. PINCZEWSKI, L. A., CLINGELEFFER, A. J., OTTO, D. D., BONAR, S. F., CORRY, I. S.: Integration of hamstring tendon graft with bone in reconstruction of the anterior cruciate ligament. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 13, 1997, 5, s. 641-643.

33. PRODROMOS, CH., BROWN, CH., FU, F. H., GEORGOULIS, A. D., GOBBI, A., HOWELL, S. M., JOHNSON, D., PAULOS, L. E., SHELBOURNE, K. D.: The anterior cruciate ligament: Reconstruction and Basic Science. Philadelphia, Elsevier Saunders, 2008.

34. RISBERG, M. A., MORK, M., JENSSEN, H. K., HOLM, I.: Design and implementation of a neuromuscular training program following anterior cruciate reconstruction. Journal of Orthopaedic & Sport Physical Therapy, 31, 2001, 11, s. 620-631.

35. ROBAYO, L. M., MOULIN, V. J., TREMBLAY, P., CLOUTIER, R., LAMONTAGNE, J., LARKIN, A. M., GOULET, F.: New ligament healing model based on tissue-engineered collagen scaffolds. Wound Repair and Regeneration, 19, 2011, 1, s. 38-48.

36. ROBERT, H., ES-SAYEH, J., HEYMANN, D., PASSUTI, N., ELOIT, S., VANEENOGE, E.: Hamstring insertion site healing after anterior cruciate ligament reconstruction in patients with symptomatic hardware or repeat rupture: A histologic study in 12 patients [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 19, 2003, 9, s. 948-954.

37. RODEO, S. A., ARNOCZKY, S. P., TORZILLI, P. A., HIDAKA, C., WARREN, R. F.: Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog [Abstract].  The Jjournal of Bone and Joint Surgery. American Volume, 75, 1993, 12, s. 1795-1803.

38. ROUGRAFF, B., SHELBOURNE, K. D., GERTH, P. K., WARNER, J.: Arthroscopic and histologic analysis of human patellar tendon autografts used for anterior cruciate ligament reconstruction [Abstract]. The American Journal of Sports Medicine, 21, 1993, 2, s. 277-284.

39. SCHEFFLER, S. U., UNTERHAUSER, F. N., WEILER, A.: Graft remodeling and ligamentization after cruciate ligament reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy, 16, 2008, 9, s. 834-842.

40. SMÉKAL, D., KALINA, R., URBAN, J.: Rehabilitace po artroskopických náhradách předního zkříženého vazu. Acta Chirurgiae Orthopedicae et Traumatologiae Čechoslovaca, 73, 2006, 6, s. 421-428.

41. SUN, L., HOU, C., WU, B., TIAN, M., ZHOU, X.: Effect of muscle preserved on tendon graft on intra-articular healing in anterior cruciate ligament reconstruction [Abstract]. Knee Ssurgery, Sport Traumatology, Arthroscopy, 21, 2013, 8, s. 1862-1868.

42. UNTERHAUSER, F. N., BAIL, H. J., HÖHER, J., HAAS, N. P. WEILER, A.: Endoligamentous revascularization of an anterior cruciate ligament graft [Abstract]. Clinical Orthopaedics and Related Research, 414, 2003, 9, s. 276-288.

43. WEILER, A., FÖRSTER, C., HUNT, P., FALK, R., JUNG, T., UNTERHAUSER, F. N., HAAS, N. P.: The influence of locally applied platelet-derived growth factor-BB on free tendon graft remodeling after anterior cruciate ligament reconstruction [Abstract]. The American Journal of Sports Medicine, 32, 2004, 4, s. 881-891.

44. WEILER, A., HOFFMANN, R. F., BAIL, H. J., REHM, O., SÜDKAMP, N. P.: Tendon healing in a bone tunnel. Part II: Biomechanical results after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 18, 2002, 2, s. 124-135.

45. WEILER, A., PEINE, R., PASHMINEH-AZAR, A., ABEL, C., SÜDKAMP, N. P., HOFFMANN, R. F.: Tendon healing in a bone tunnel. Part I: Biomechanical results after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 18, 2002, 2, s. 113-123.

46. WEILER, A., PETERS, G., MÄURER, J., UNTERHAUSER, F. N., SÜDKAMP, N. P.: Biomechanical properties and vascularity of an anterior cruciate ligament graft can be predicted by contrast-enhanced magnetic resonance imaging: A two-year study in sheep. The American Journal of Sports Medicine, 29, 2001, 6, s. 751-761.

47. WEN, C. Y., QIN, L., LEE, K. M., WONG, M. W. N., CHAN, K. M.: Grafted tendon healing in tibial tunnel is inferior to healing in femoral tunnel after anterior cruciate ligament reconstruction: A histomorphometric study in rabbits [Abstract]. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 26, 2010, 1, s. 58-66.

48. YOSHIKAWA, T., TOHYAMA, H., KATSURA, T., KONDO, E., KOTANI, Y., MATSUMOTO, H., YASUDA, K.: Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. The American Journal of Sports Medicine, 34, 2006, 12, s. 1918-1925.

49. YOSHIYA, S., NAGANO, M., KUROSAKA, M., MURATSU, H., MIZUNO, K.: Graft healing in the bone tunnel in anterior cruciate ligament reconstruction [Abstract]. Clinical Orthopaedics and Related Research, 376, 2000, 7, s. 278-286.

Labels
Physiotherapist, university degree Rehabilitation Sports medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#