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Pneumoperitoneum in dis­eases and traumas of the upper part of the digestive tract –⁠ an overview of current knowledge and clinical context


Authors: P. Horák;  A. Erbenová;  V. Bendová;  M. Šnajdauf
Authors‘ workplace: Chirurgická klinika 1. LF UK a FN Bulovka, PrahaIPVZ, Praha
Published in: Rozhl. Chir., 2026, roč. 105, č. 5, s. 204-211.
Category: Review
doi: https://doi.org/10.48095/ccrvch2026204

Overview

Pneumoperitoneum is a clinically significant and dia­gnostically important finding that most commonly indicates perforation of a hol­low organ within the gastrointestinal tract. Within the upper gastrointestinal tract, the most frequent cause of pneumoperitoneum is gastroduodenal perforation. However, less common etiologies must also be considered, including perforation of the distal esophagus, gallbladder, or bile ducts resulting from inflammatory dis­ease, trauma, or iatrogenic injury. Dia­gnosis is based on a combination of clinical assessment, imaging modalities, and supportive laboratory parameters. Plain abdominal radiography has limited sensitivity in detecting small amounts of free intraperitoneal gas; therefore, contrast-enhanced computed tomography is currently considered the dia­gnostic standard. Management of free gastrointestinal perforation is primarily surgical, whereas selected forms of pneumoperitoneum may be treated conservatively or endoscopically. The choice of surgical procedure depends on the affected organ, intraoperative findings, and the patient’s overall clinical condition. Early recognition of the condition is essential for improving clinical outcomes and reducing patient morbidity and mortality.

Keywords:

treatment – pneumoperitoneum –  upper gastrointestinal tract – diagnostic techniques


Sources

1. Pitiakoudis M, Zezos P, Oikonomou A et al. Spontaneous idiopathic pneumoperitoneum presenting as an acute abdomen: a case report. J Med Case Rep 2011; 5 : 86. doi: 10.1186/ 1752-1947-5-86.

2. Horák P, Peregrinová M, Erbenová A et al. Pneumoperitoneum, pneumomediastinum and subcutaneous emphysema fol­lowing argon plasma coagulation treatment of colonic angioectasia. Rozhl Chir 2023; 102(3): 130 –⁠ 133. doi: 10.33699/ PIS.2023.102.3.130-133.

3. Pinto A, Miele V, Schillirò ML et al. Spectrum of signs of pneumoperitoneum. Semin Ultrasound CT MRI 2016; 37(1): 3 –⁠ 9. doi: 10.1053/ j.sult.2015.10.008.

4. Souadka A, Mohsine R, Ifrine L et al. Acute abdominal compartment syndrome complicating a colonoscopic perforation: a case report. J Med Case Rep 2012; 6 : 51. doi: 10.1186/ 1752-1947-6-51.

5. Alizadeh L, Shakeri-Darzekonani M, Sadrazar A et al. Conservative management of asymptomatic pneumoperitoneum; report of two cases. Arch Acad Emerg Med 2019; 7(1): e12.

6. Furukawa A, Sakoda M, Yamasaki M et al. Gastrointestinal tract perforation: CT dia­g­­nosis of presence, site, and cause. Abdom Imaging 2005; 30(5): 524 –⁠ 534. doi: 10.1007/ s00261-004-0289-x.

7. Cho KC, Baker SR. Extraluminal air. Dia­g­nosis and significance. Radiol Clin North Am 1994; 32(5): 829 –⁠ 844.

8. Ghahremani GG. Radiologic evaluation of suspected gastrointestinal perforations. Radiol Clin North Am 1993; 31(6): 1219 –⁠ 1234.

9. Maniatis V, Chryssikopoulos H, Roussakis A et al. Perforation of the alimentary tract: evaluation with computed tomography. Abdom Imaging 2000; 25(4): 373 –⁠ 379. doi: 10.1007/ s002610000022.

10. Marshall GB. The cupola sign. Radiology 2006; 241(2): 623 –⁠ 624. doi: 10.1148/ radiol.2412040700.

11. Pavlovic A, Herrington T, Mijovic K et al. Dia­gnostic accuracy of computed tomography in localizing gastrointestinal perforations: focusing on gastric and duodenal defects. Eur J Radiol 2025; 190 : 112192. doi: 10.1016/ j.ejrad.2025.112192.

12. Peirce GS, Swisher JP, Freemyer JD et al. Postoperative pneumoperitoneum on computed tomography: is the operation to blame? Am J Surg 2014; 208(6): 949 –⁠ 953. doi: 10.1016/ j.amjsurg.2014.09.006.

13. Gayer G, Jonas T, Apter S et al. Postoperative pneumoperitoneum as detected by CT: prevalence, duration, and relevant factors affecting its possible significance. Abdom Imaging 2000; 25(3): 301 –⁠ 305. doi: 10.1007/ s002610000036.

14. Malgras B, Placé V, Dohan A et al. Natural history of pneumoperitoneum after laparotomy: findings on multidetector-row computed tomography. World J Surg 2017; 41(1): 56 –⁠ 63. doi: 10.1007/ s00268-016-3648-1.

15. Hoffmann B, Nürnberg D, Westergaard MC. Focus on abnormal air: dia­gnostic ultrasonography for the acute abdomen. Eur J Emerg Med 2012; 19(5):284 –⁠ 291. doi: 10.1097/ MEJ.0b013e3283543cd3.

16. Bacci M, Kushwaha R, Cabrera G et al. Point-of-care ultrasound dia­gnosis of pneumoperitoneum in the emergency department. Cureus 2020; 12(6): e8503. doi: 10.7759/ cureus.8503.

17. Faggian A, Berritto D, Iacobellis F et al. Imaging patients with alimentary tract perforation: literature review. Semin Ultrasound CT MR 2016; 37(1): 66 –⁠ 69. doi: 10.1053/ j.sult.2015.09.006.

18. Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 1990; 19(4): 793 –⁠ 810.

19. McGlone FB, Vivion CG, Meir L. Spontaneous penumoperitoneum. Gastroenterology 1966; 51(3): 393 –⁠ 398.

20. Williams NM, Watkin DF. Spontaneous pneumoperitoneum and other nonsurgical causes of intraperitoneal free gas. Postgrad Med J 1997; 73(863): 531 –⁠ 537. doi: 10.1136/ pgmj.73.863.531.

21. Blum CA, Selander C, Ruddy JM et al. The incidence and clinical significance of pneumoperitoneum after percutaneous endoscopic gastrostomy: a review of 722 cases. Am Surg 2009; 75(1): 39 –⁠ 43.

22. Chen CK, Su YJ, Lai YC et al. Gas-forming bacterial peritonitis mimics hol­low organ perforation. Am J Emerg Med 2008; 26(7): 838.e3 –⁠ 838.e5. doi: 10.1016/ j.ajem.2008.01.034.

23. Karvellas CJ, Abraldes JG, Arabi YM et al. Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study. Aliment Pharmacol Ther 2015; 41(8): 747 –⁠ 757. doi: 10.1111/ apt.13135.

24. Kotek J, Dušek T, Sirový M et al. Pneumatosis cystoides intestinalis as a rare cause of non-surgical pneumoperitoneum. Rozhl Chir 2023; 102(5): 214 –⁠ 218. doi: 10.33699/ PIS.2023.102.5.214-218.

25. Zafar SN, Rushing A, Haut ER et al. Outcome of selective non-operative management of penetrating abdominal injuries from the North American National Trauma Database. Br J Surg 2012; 99(Suppl 1): 155 –⁠ 164. doi: 10.1002/ bjs.7735.

26. Felder SI, Barmparas G, Murrell Z et al. Risk factors for failure of percutaneous drainage and need for reoperation fol­lowing symptomatic gastrointestinal anastomotic leak. Am J Surg 2014; 208(1): 58 –⁠ 64. doi: 10.1016/ j.amjsurg.2013.08.050.

27. Udelsman B, Lee K, Qadan M et al. Management of pneumoperitoneum: role and limits of nonoperative treatment. Ann Surg 2021; 274(1): 146 –⁠ 154. doi: 10.1097/ SLA.0000000000003492.

28. Paspatis GA, Dumonceau JM, Barthet M et al. Dia­gnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) position statement. Endoscopy 2014; 46(8): 693 –⁠ 711. doi: 10.1055/ s-0034-1377531.

29. Søreide JA, Viste A. Esophageal perforation: dia­gnostic work-up and clinical decision-making in the first 24 hours. Scand J Trauma Resusc Emerg Med 2011; 19 : 66. doi: 10.1186/ 1757-7241-19-66.

30. Brinster CJ, Singhal S, Lee L et al. Evolving options in the management of esophageal perforation. Ann Thorac Surg 2004; 77(4): 1475 –⁠ 1483. doi: 10.1016/ j.athoracsur.2003.08.037.

31. Widana Pathirana P, Liyanage C. Pneumoperitoneum post esophageal stent insertion managed with paracentesis. J Med Cases 2022; 13(4): 178 –⁠ 182. doi: 10.14740/ jmc3920.

32. Safavi A, Wang N, Razzouk A et al. One--stage primary repair of distal esophageal perforation using fundic wrap. Am Surg 1995; 61(10): 919 –⁠ 924.

33. Sudarshan M, Cassivi SD. Management of traumatic esophageal injuries. J Thorac Dis 2019; 11(Suppl 2): S172 –⁠ S176. doi: 10.21037/ jtd.2018.10.86.

34. Behrman SW. Management of complicated peptic ulcer dis­ease. Arch Surg 2005; 140(2): 201 –⁠ 208. doi: 10.1001/ archsurg.140.2.201.

35. Hermansson M, Ekedahl A, Ranstam J et al. Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974 –⁠ 2002. BMC Gastroenterol 2009; 9 : 25. doi: 10.1186/ 1471-230X-9-25.

36. Chung KT, Shelat VG. Perforated peptic ulcer –⁠ an update. World J Gastrointest Surg 2017; 9(1): 1 –⁠ 12. doi: 10.4240/ wjgs.v9.i1.1.

37. Andrabi SA, Andrabi SI, Mansha M et al. An iatrogenic complication of closed tube thoracostomy for penetrating chest trauma. N Z Med J 2007; 120(1264): U2784.

38. Spoormans I, Van Hoorenbeeck K, Balliu L et al. Gastric perforation after cardiopulmonary resuscitation: review of the literature. Resuscitation 2010; 81(3): 272 –⁠ 280. doi: 10.1016/ j.resuscitation.2009.11.023.

39. Isomoto H, Shikuwa S, Yamaguchi N et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut 2009; 58(3): 331 –⁠ 336. doi: 10.1136/ gut.2008.165381.

40. Chao HH, Chao TC. Perforation of the duodenum by an ingested toothbrush. World J Gastroenterol 2008; 14(27): 4410 –⁠ 4412. doi: 10.3748/ wjg.14.4410.

41. Kim HJ, Park JS, Park SJ et al. Survival and prognostic factors after surgery in single spinal metastasis: comparison of isolated--single spinal metastasis and single spinal metastasis with other metastasis. Global Spine J 2024; 15(4): 2246 –⁠ 2254. doi: 10.1177/ 21925682241295666.

42. Sharma D, Gupta A, Jain BK et al. Tuberculous gastric perforation: report of a case. Surg Today 2004; 34(6): 537 –⁠ 541. doi: 10.1007/ s00595-004-2745-1.

43. Ren J, Ding J, Su T et al. Evaluation and management of symptomatic duodenal diverticula: a single-center retrospective analysis of 647 patients. Front Surg 2023; 10 : 1267436. doi: 10.3389/ fsurg.2023.1267436.

44. Oukachbi N, Brouzes S. Management of complicated duodenal diverticula. J Visc Surg 2013; 150(3): 173 –⁠ 179. doi: 10.1016/ j.jviscsurg.2013.04.006.

45. Horowitz J, Kukora JS, Ritchie WP. All perforated ulcers are not alike. Ann Surg 1989; 209(6): 693 –⁠ 696. doi: 10.1097/ 00000658-198906000-00006.

46. Agaba EA, Klair T, Ikedilo O et al. A 10-yearreview of surgical management of complicated peptic ulcer dis­ease from a single center: is laparoscopic approach the future? Surg Laparosc Endosc Percutan Tech 2016; 26(5): 385 –⁠ 390. doi: 10.1097/ SLE.0000000000000312.

47. Andersen IB, Jørgensen T, Bonnevie O et al. Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology 2000; 11(4): 434 –⁠ 439. doi: 10.1097/ 00001648-200007000-00012.

48. Buck DL, Vester-Andersen M, Møller MH. Surgical delay is a critical determinant of survival in perforated peptic ulcer. Br J Surg 2013; 100(8): 1045 –⁠ 1049. doi: 10.1002/ bjs.9175.

49. Tarasconi A, Coccolini F, Biffl WL et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg 2020; 15 : 3. doi: 10.1186/ s13017-019-0283-9.

50. Fraga GP, Biazotto G, Bortoto JB et al. The use of pyloric exclusion for treating duodenal trauma: case series. Sao Paulo Med J 2008; 126(6): 337 –⁠ 341. doi: 10.1590/ s1516-31802008000600009.

51. Miyahara H, Shida D, Matsunaga H et al. Emphysematous cholecystitis with massive gas in the abdominal cavity. World J Gastroenterol 2013; 19(4): 604 –⁠ 606. doi: 10.3748/ wjg.v19.i4.604.

52. Nance ML, Peden GW, Shapiro MB et al. Solid viscus injury predicts major hol­low viscus injury in blunt abdominal trauma. J Trauma 1997; 43(4): 618 –⁠ 622. doi: 10.1097/ 00005373-199710000-00009.

53. Ishikawa K, Ueda Y, Sonoda K et al. Multiple gastric ruptures caused by blunt abdominal trauma: report of a case. Surg Today 2002; 32(11): 1000 –⁠ 1003. doi: 10.1007/ s005950200201.

54. Tejerina Alvarez EE, Holanda MS, López-Espadas F et al. Gastric rupture from blunt abdominal trauma. Injury 2004; 35(3): 228 –⁠ 231. doi: 10.1016/ s0020-1383(03)00212-2.

55. Oncel D, Malinoski D, Brown C et al. Blunt gastric injuries. Am Surg 2007; 73(9): 880 –⁠ 883.

56. Watts DD, Fakhry SM. Incidence of hol­low viscus injury in blunt trauma: an analysis from 275,557 trauma admissions from the East multi-institutional trial. J Trauma 2003; 54(2): 289 –⁠ 294. doi: 10.1097/ 01.TA.0000046261.06976.6A.

57. Fakhry SM, Watts DD, Luchette FA. Current dia­gnostic approaches lack sensitivity in the dia­gnosis of perforated blunt small bowel injury: analysis from 275,557 trauma admissions from the EAST multi-institutional HVI trial. J Trauma 2003; 54(2): 295 –⁠ 306. doi: 10.1097/ 01.TA.0000046256.80836.AA.

58. Atri M, Hanson JM, Grinblat L et al.Surgically important bowel and/ ormesenteric injury in blunt trauma:accuracy of multidetector CT forevaluation. Radiology 2008; 249(2):524 –⁠ 533. doi: 10.1148/ radiol.2492072055.

59. Brown MA, Sirlin CB, Hoyt DB et al. Screening ultrasound in blunt abdominal trauma. J Intensive Care Med 2003; 18(5): 253 –⁠ 260. doi: 10.1177/ 0885066603256103.

60. Fakhry SM, Brownstein M, Watts DD et al. Relatively short dia­gnostic delays (<8 hours) produce morbidity and mortality in blunt small bowel injury: an analysis of time to operative intervention in 198 patients from a multicenter experience. J Trauma 2000; 48(3): 408 –⁠ 414. doi: 10.1097/ 00005373-200003000-00007.

61. Lorente-Ramos RM, Santiago-Hernando A, Del Valle-Sanz Y et al. Sonographic dia­gnosis of intramural duodenal hematomas. J Clin Ultrasound 1999; 27(4): 213 –⁠ 216. doi: 10.1002/ (sici)1097-0096(199905)27 : 4<213::aid-jcu10>3.0.co;2-k.

62. Schreiber MA. Damage control surgery. Crit Care Clin 2004; 20(1): 101 –⁠ 118. doi: 10.1016/ s0749-0704(03)00095-2.

63. Gayer G, Hertz M, Zissin R. Postoperative pneumoperitoneum: prevalence, duration, and possible significance. Semin Ultrasound CT MR 2004; 25(3): 286 –⁠ 289. doi: 10.1053/ j.sult.2004.03.009.

64. Wells CI, Bhat S, Alexander H et al. Natural history and clinical significance of postoperative pneumoperitoneum: a systematic review and meta-analysis.Clin Radiol 2025; 92 : 107158. doi: 10.1016/ j.crad.2025.107158.

65. Chapman BC, McIntosh KE, Jones EL et al. Postoperative pneumoperitoneum: is it normal or pathologic? J Surg Res 2015; 197(1): 107 –⁠ 111. doi: 10.1016/ j.jss.2015.03.083.

MU Dr. Pavel Horák

Chirurgická klinika

1. LF UK a FN Bulovka

Budínova 67/2

180 81 Praha 8

pavel.horak@bulovka.cz

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Surgery Orthopaedics Trauma surgery
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