Colorectal cancer − the importance of primary tumor location
Authors:
M. Ryska 1,3; J. Bauer 2
Authors‘ workplace:
Chirurgická klinika 2. LF Univerzity Karlovy a ÚVN, Praha
přednosta: prof. MUDr. M. Ryska, CSc.
1; emeritní docent 1. LF Univerzity Karlovy
2; Fakulta zdravotníctva a sociálnej práce, Trnavská Univerzita, Trnava
děkan: prof. MUDr. J. Slaný, CSc.
3
Published in:
Rozhl. Chir., 2017, roč. 96, č. 1, s. 4-8.
Category:
Review
Overview
Retrospective evaluations of the relevance of primary colorectal cancer (CRC) location consistently indicate that right-sided tumors, arising in the cecum, ascending colon, hepatic bend, transverse colon and splenic flexure, are clinically, biologically and genetically different from left-sided tumors – those located in the descending colon, sigmoid colon or rectum. Location in the right-sided colon represents a negative prognostic indicator, particularly for stage III and IV carcinomas. Irrespective of treatment, the rightward location is associated with a significantly increased risk of death when compared to the left side.
Key words:
colorectal cancer – location – therapy - prognosis
Sources
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