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Simultaneous Transplantation of the Kidney and the Islets of Langerhans


Authors: T. Marada;  K. Lipár;  M. Adamec;  P. Girman *;  J. Kříž *;  F. Saudek *
Authors‘ workplace: Klinika transplantační chirurgie, IKEM, přednosta: prof. MUDr. Miloš Adamec, CSc. ;  Klinika diabetologie, IKEM, přednosta: prof. MUDr. František Saudek, DrSc. *
Published in: Rozhl. Chir., 2011, roč. 90, č. 2, s. 111-113.
Category: Monothematic special - Original

Overview

Simultaneous kidney and islet transplantation is recent therapeutic alternative for diabetics with end-stage kidney disease, who are not acceptable for simultaneous pancreas-kidney transplantation. Islet transplantation has less complications but still worse long-term function compared to whole pancreas transplantation.

Key words:
diabetes – islets of Langerhans – kidney – pancreas – transplantation


Sources

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2. Bartoš, V., Vaněk, I. Experience of the Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia. International Handbook of Pancreas Transplantation. Kluwer Academic Publisher, 1989; 423–427.

3. Adamec, M., et al. Transplantace slinivky břišní. Praha, Karolinum, 2006.

4. Robertson, P., Davis, C., Larsen, J., et al. Pancreas transplantation in type 1 diabetes. Diabetes Care, 2004; 27: 105.

5. Venstrom, J. M., McBride, M. A., Rother, K. I., et al. Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA, 2003; 290: 2817–2823.

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7. Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med., 2000; 343: 230–238.

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9. Kim, S. J., Yang, T. Y., Jeong, I. K., Lee, M. K., et al. Retransplantation of Islets After Simultaneous Islet-Kidney Transplantation: A Case Report. Transplantation Proceedings, 2003; 35: 476–478.

10. Gerber, P. A., Pavlicek, V., Demartines, N., et al. Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up. Diabetologia, 2008; 51: 110–119.

11. Lehmann, R., Weber, M., Berthold, P., et al. Successful simultaneous islet-kidney transplantation using a steroid-free immunosuppression: two-year follow-up. Am. J. Transplant., 2004; 4: 1117–1123.

12. Wilczek, H., Jaremko, G., Tydén, G., et al. Evolution of diabetic nephropathy in kidney grafts. Evidence that simultaneously transplanted pancreas exerts a protective efect. Transplantation, 1995; 59: 51–57.

Labels
Surgery Orthopaedics Trauma surgery
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