Preoperative Radiotherapy in Hypoxia in the Complex Treatment of the Rectal Carcinoma – Long Term Results

Czech version

Authors: V. Sihotský ¹; P. Šlampa ²; T. Skřička ⁶; T. Tačev ²; J. Vomela ⁴; J. Všetíček ⁵; J. Žaloudík ³
Authors‘ workplace: I. Chirurgická klinika FNLP, Košice, prednosta: prof. MUDr. J. Bober, CSc. ¹; Masarykův onkologický ústav, Brno, Odd. radiačnej onkológie, primár doc. MUDr. P. Šlampa, CSc. ²; Masarykův onkologický ústav, Brno, Odd. chirurgickej onkológie, primár MUDr. V. Chrenko, CSc. ³; Chirurgická klinika FN Brno, Bohunice, prednosta: prof. MUDr. J. Vomela, CSc. ⁴; Nemocnice Milosrdných bratří, Brno, chirurgické odd. primár MUDr. J. Všetíček, Ph. D. ⁵; Bakešova chirurgická nemocnice, Brno, riaditeľ: doc. MUDr. T. Skřička, CSc. ⁶
Published in: Rozhl. Chir., 2006, roč. 85, č. 9, s. 469-474.
Category: Monothematic special - Original

Overview

Introduction:
The aim of this study was to evaluate long term results of patients with rectal carcinoma which were irradiated in hypoxic conditions.

Patients and methods:
Of all patients which were irradiated in hypoxic conditions in Masaryk Memorial institute, 93 patients were followed up longer time than five year.

Results:
The most common surgical procedure was resection in 60%, overall five year survival was 73.1%, systemic relapse of disease occurred in 33.3% and local recurrence rate was 13.9%.

Conclusion:
Preoperative irradiation in hypoxic conditions permits safe administration of doses higher than those tolerated by normooxic conditions, without increase of complication. Long term results are comparable with crucial trials.

Key words:
rectal carcinoma – preoperative radiotherapy – hypoxyradiotherapy