Clinical experience with the treatment of inverted papilloma at the Department of Otorhinolaryngology and Maxillofacial Surgery of the 3rd Faculty of Medicine, Charles University and Central Military Hospital between 2013 –⁠ 2023

Czech version

Authors: D. Kovář ^1,2; K. Mamiňák ^1,2; T. Filipovský ^1,2; Jaromír Astl ^1,2
Authors‘ workplace: Klinika otorinolaryngologie a maxilofaciální chirurgie 3. LF UK a ÚVN Praha ¹; 3. lékařská fakulta, Univerzita Karlova, Praha ²
Published in: Otorinolaryngol Foniatr, 73, 2024, No. 3, pp. 160-166.
Category: Original Article
doi: https://doi.org/10.48095/ccorl2024160

Overview

Introduction: Inverted papilloma (IP) is a benign tumor of the nasal cavity and paranasal sinuses (PNS) that typically manifests unilaterally, peaks in incidence in 50–60 year-olds, and is more common in men. An endoscopic examination, including biopsy and imaging to ascertain the tumor‘s extent, is part of the diagnosis. IP is mainly treated surgically, with endoscopic endonasal resection being the preferred procedure. Methods and materials: In total, 34 IP patients in our group between 2013 and the end of 2023 were retrospectively analysed. Approximately 94% of them experienced unilateral incidence. The maxillary cavity and lateral wall of the nasal cavity were the tumor‘s most frequent locations. Results: Endoscopic IP resection was utilized in 42% of the procedures in our group. Combined or external procedures were used for larger tumors or recurrences. Within two years following surgery, 52% of patients experienced a recurrence of IP. Of the total number of patients, 26% experienced one recurrence, and 10% experienced more than one recurrence throughout the monitored period. Conclusions: For the treatment of IP, the radicality of the procedure (negative resection margine) is crucial. Long-term follow-up is advised to lower the chance of recurrences and to distinguish any potential malignant transformation.

Keywords:

inverted papilloma – Endoscopic surgery – retrospective study

Sources

1. Thompson LD, Müller S, Nelson BL. Diagnostic Pathology: Head and Neck, vol. 3rd ed. Amsterdam: Elsevier Health Sciences 2022.

2. Sunkara PR, Saraswathula A, Ramanathan M, Jr. Etiology of sinonasal inverted papilloma: An update. Laryngoscope Investig Otolaryngol 2022; 7 (5): 1265–1273. Doi: 10.1002/lio2.821.

3. Jewett FC, 3rd, Coulter MJ, Nelson BL. Sine Qua Non: Sinonasal Inverted Papilloma. Head Neck Pathol 2021; 15 (3): 950–954. Doi: 10.1007/ s12105-021-01289-6.

4. Ding R, Sun Q, Wang Y. Association Between Human Papilloma Virus Infection and Malignant Sinonasal Inverted Papilloma. Laryngoscope 2021; 131 (6): 1200–1205. Doi: 10.1002/ lary.29125.

5. Lisan Q, Laccourreye O, Bonfils P. Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis 2016; 133 (5): 337–341. Doi: 10.1016/ j.anorl.2016.03.006.

6. Kamel RH, Khaled A, Abdelfattah AF et al. Surgical treatment of sinonasal inverted papilloma. Curr Opin Otolaryngol Head Neck Surg 2022; 30 (1): 26–32. Doi: 10.1097/MOO.000000000 0000781.

7. Peng R, Thamboo A, Choby G et al. Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta-analysis. Int Forum Allergy Rhinol 2019; 9 (6): 573–581. Doi: 10.1002/alr.22305.

8. Rha MS, Kim CH, Yoon JH et al. Association of the human papillomavirus infection with the recurrence of sinonasal inverted papilloma: a systematic review and meta-analysis. Rhinology 2022; 60 (1): 2–10. Doi: 10.4193/Rhin21.255.

9. Stepp WH, Farzal Z, Kimple AJ et al. HPV in the malignant transformation of sinonasal inverted papillomas: A meta-analysis. Int Forum Allergy Rhinol 2021; 11 (10): 1461–1471. Doi: 10.1002/alr.22810.

10. Eide JG, Welch KC, Adappa ND et al. Sinonasal Inverted Papilloma and Squamous Cell Carcinoma: Contemporary Management and Patient Outcomes. Cancers (Basel) 2022; 14 (9). Doi: 10.3390/cancers14092195.

11. Ferreli F, Di Bari M, Moya-Plana A et al. Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis. Am J Otolaryngol 2022; 43 (6): 103614. Doi: 10.1016/j.amjoto.2022.103614.

12. Jeon TY, Kim HJ, Chung SK et al. Sinonasal inverted papilloma: value of convoluted cerebriform pattern on MR imaging. AJNR Am J Neuroradiol 2008; 29 (8): 1556–1560. Doi: 10.3174/ajnr.A1128.

13. Krouse JH. Development of a staging system for inverted papilloma. Laryngoscope 2000; 110 (6): 965–968. Doi: 10.1097/00005537 -⁠ 200006000-00015.

14. Kamel R, Khaled A, Kandil T. Inverted papilloma: new classification and guidelines for endoscopic surgery. Am J Rhinol 2005; 19 (4): 358–364.

15. Dragonetti A, Gera R, Sciuto A et al. Sinonasal inverted papilloma: 84 patients treated by endoscopy and proposal for a new classification. Rhinology 2011; 49 (2): 207–213. Doi: 10.4193/Rhino09.053.

16. Schalek P. FL. Invertovaný sinonazální papilom –⁠ současné principy chirurgické léčby. Otorinolaryngol Foniatr 2013; 62 (1): 26–30.

17. Yu S, Grose E, Lee DJ et al. Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review. J Otolaryngol Head Neck Surg 2023; 52 (1): 34. Doi: 10.1186/s40463-023-00638-5.

18. Balatkova Z, Plzák J., Betka J. Léčba invertovaného papilomu. Endoskopie 2012; 21 (1): 35–37.

ORCID autorů

D. Kovář 0000-0002-7370-264X,

K. Mamiňák 0000-0002-3935-5891,

T. Filipovský 0000-0002-9462-0635,

J. Astl 0000-0002-8022-0200.

Přijato k recenzi: 20. 6. 2024

Přijato do tisku: 19. 9. 2024

MUDr. Daniel Kovář, Ph.D.

Klinika otorinolaryngologie a maxilofaciální chirurgie

3. LF UK a ÚVN Praha

U Vojenské nemocnice 1200