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Relevance of Measurement of Nasal Nitric Oxide as Bioindicator of Inflammation in Otorhinolaryngology


Authors: T. Rybnikár 1;  P. Čelakovský 1,2;  D. Kalfeřt 1
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku, Fakultní nemocnice Hradec Králové 1;  Lékařská fakulta v Hradci Králové, Univerzita Karlova v Praze, přednosta prof. MUDr. V. Chrobok, CSc., Ph. D. 2
Published in: Otorinolaryngol Foniatr, 64, 2015, No. 1, pp. 50-54.
Category: Review Article

Overview

Nitric oxide (NO) is produced in high concentration in the upper respiratory tract. The high concentration of NO is toxic to bacteria and viruses and thus helps to defend the mucous membranes of upper respiratory tract. In recent years is an increasing worldwide interest in the measurement of nasal nitric oxide (nNO) in diseases of the upper respiratory tract. In the literature, are starting to publish work about the measurement of nasal nitric oxide in ciliary dyskinesia, adenoid vegetation, allergic rhinitis or acute and chronic rhinosinusitis. The measurement of nasal nitric oxide in otorhinolaryngology is based only on several experimental studies yet. More clinical data are necessary to consider a true impact for clinical treatment.

Keywords:
nasal nitric oxide, chemiluminescent analyser, primary ciliary dyskinesia, allergic rhinitis, rhinosinusitis


Sources

1. Alberty, J., Stoll, W., Rudack, C.: The effect of endogenous nitric oxide on mechanical ciliostimulation of human nasal mucosa. Clin. Exp. Allergy, 36, 2006, 10, s. 1254-1259.

2. Slobod, I., Benitez, P., Valero, A., Munoz, R., Langdon, C., Mullol, J.: Oral and intranasal steroid treatments improve nasal patency and paradoxically increase nasal nitric oxide in patients with severe nasal polyposis. Rhinology, 50, 2012 2, s.171-177.

3. Alving, K., Weitzberg, E., Lundberg, J. M.: Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J., 6, 1993, 9, s. 1368-1370.

4. Andersson, J. A., Cervin, A., Lindberg, S., Uddman, R., Cardell, L. O.: The paranasal sinuses as reservoirs for nitric oxide. Acta Otolaryngol, 122, 2002, 8, s. 861-865.

5. Balfour-Lynn, I. M., Laverty, A., Dinwiddie, R.: Reduced upper airway nitric oxide in cystic fibrosis. Arch. Dis. Child, 75, 1996, 4, s. 319-322.

6. Baraldi, E., Azzolin, N. M., Biban, P., Zacchello, F.: Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis. Am. J. Respir. Crit. Care Med., 155, 1997, 5, s. 1680-1683.

7. Baraldi, E., Azzolin, N. M., Carra, S., Dario, C., Marchesi-ni, L., Zacchello, F.: Effect of topical steroids on nasal nitric oxide production in children with perennial allergic rhinitis: a pilot study. Respir. Med., 92, 1998, 3, s. 558-561.

8. Bommarito, L., Guida, G., Heffler, E., Badiu, I., Nebiolo, F., Usai, A., De Stefani, A., Rolla, G.: Nasal nitric oxide concentration in suspected chronic rhinosinusitis. Ann. Allergy Asthma Immunol., 101, 2008, 4, s. 358-362.

9. Corbelli, R., Bringolf-Isler, B., Amacher, A., Sasse, B., Spycher, M., Hammer, J.: Nasal nitric oxide measurements to screen children for primary ciliary dyskinesia. Chest, 126, 2004, 4, s. 1054-1059.

10. Corbelli, R., Hammer, J.: Measurement of nasal nitric oxide. Paediatr. Respir. Rev., 8, 2007, 3, s. 269-272.

11. Cremona, G., Higenbottam, T., Borland, C., Mist, B.: Mixed expired nitric oxide in primary pulmonary hypertension in relation to lung diffusion capacity. Qjm, 87, 1994, 9, s. 547-551.

12. de Gouw, H. W., Grunberg, K., Schot, R., Kroes, A. C.,Dick, E. C., Sterk, P. J.: Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur. Respir. J., 11, 1998, 1, s. 126-132.

13. Deja, M., Busch, T., Bachmann, S., Riskowski, K., Cam-pean, V., Wiedmann, B., Schwabe, M., Hell, B., Pfeilschifter, J., Falke, K. J. et al.: Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. Am. J. Respir. Crit. Care Med., 168, 2003, 3, s. 281-286.

14. Dotsch, J., Demirakca, S., Terbrack, H. G., Huls, G., Ras-cher, W., Kuhl, P. G.: Airway nitric oxide in asthmatic children and patients with cystic fibrosis. Eur. Respir. J., 9, 1996, 12, s. 2537-2540.

15. Fang, F. C.: Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest, 99, 1997, 12, s. 2818-2825.

16. Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P.,Moncada, S.: Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem. Biophys Res. Commun., 181, 1991, 2, s. 852-857.

17. Horvath, I., Loukides, S., Wodehouse, T., Csiszer, E.,Cole, P. J., Kharitonov, S. A., Barnes, P. J.: Comparison of exhaled and nasal nitric oxide and exhaled carbon monoxide levels in bronchiectatic patients with and without primary ciliary dyskinesia. Thorax, 58, 2003, 1, s. 68-72.

18. Chládková, J., Chládek, J.: V čem spočívá přínos měření vydechovaného oxidu dusnatého u dětí s průduškovým astmatem. Kazuistiky Alergol. Pneumol. ORL, 6, 2009, 4, s. 20-24.

19. Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., Chaudhuri, G.: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U S A, 84, 1987, 24, s. 9265-9269.

20. Jeon, E. J., Park, Y. S., Lee, S. K., Yeo, S. W., Park, S. N., Chang, K. H.: Effect of nitric oxide and peroxynitrite on mucociliary transport function of experimental otitis media. Otolaryngol. Head Neck Surg., 134, 2006, 1, s. 126-131.

21. John, E. O., Russell, P. T., Nam, B. H., Jinn, T. H., Jung, T. T.: Concentration of nitric oxide metabolites in middle ear effusion. Int. J. Pediatr. Otorhinolaryngol., 60, 2001, 1, s. 55-58.

22. Jorissen, M., Lefevere, L., Willems, T.: Nasal nitric oxide. Allergy, 56, 2001, 11, s. 1026-1033.

23. Kharitonov, S. A., Barnes, P. J.: Exhaled markers of pulmonary disease. Am. J. Respir. Crit. Care Med., 163, 2001, 7, s. 1693-1722.

24. Kharitonov, S. A., Rajakulasingam, K., O’Connor, B., Durham, S. R., Barnes, P. J.: Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. J. Allergy Clin. Immunol., 99, 1997, 1 Pt 1, s. 58-64.

25. Kramer, M. F., Olzowy, B.: Exhaled and nasal nitric oxide in laryngectomized patients. Pulm. Med., 10, 2010, 4.

26. Lala, P. K., Chakraborty, C.: Role of nitric oxide in carcinogenesis and tumour progression. Lancet. Oncol., 2, 2001, 3, s. 149-156.

27. Lee, K. J., Cho, S. H., Lee, S. H., Tae, K., Yoon, H. J., Kim, S. H.,Neony, J. H.: Nasal and exhaled nitric oxide in allergic rhinitis. Clin. Exp. Otorhinolaryngol., 5, 2012, 4, s. 228-233.

28. Lindberg, S., Cervin, A., Runer, T.: Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis. Acta Otolaryngol., 117, 1997, 1, s. 113-117.

29. Loveless, M. O., Phillips, C. R., Giraud, G. D., Holden, W. E.:Decreased exhaled nitric oxide in subjects with HIV infection. Thorax, 52, 1997, 2, s. 185-186.

30. Lundberg, J. O., Nordvall, S. L., Weitzberg, E., Kollberg, H., Alving, K.: Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch. Dis. Child, 75, 1996, 4, s. 323-326.

31. Lundberg, J. O., Rinder, J., Weitzberg, E., Lundberg, J. M.,Alving, K.: Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol. Scand., 152, 1994, 4, s. 431-432.

32. Lundberg, J. O., Settergren, G., Gelinder, S., Lundberg, J. M., Alving, K., Weitzberg, E.: Inhalation of nasally derived nitric oxide modulates pulmonary function in humans. Acta Physiol. Scand., 158, 1996, 4, s. 343-347.

33. Moncada, S.: The L-arginine: nitric oxide pathway, cellular transduction and immunological roles. Adv. Second Messenger Phosphoprotein Res., 28, 1993, s. 97-99.

34. Palmer, R. M., Ferrige, A. G., Moncada, S.: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 1987, 6122, s. 524-526.

35. Pedroletti, C., Lundahl, J., Alving, K., Hedlin, G.: Effect of nasal steroid treatment on airway inflammation determined by exhaled nitric oxide in allergic schoolchildren with perennial rhinitis and asthma. Pediatr. Allergy Immunol., 19, 2008, 3, s. 219-226.

36. Ragab, S. M., Lund, V. J., Saleh, H. A., Scadding, G.: Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy. Allergy, 61, 2006, 6, s. 717-724.

37. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am. J. Respir. Crit. Care Med., 160, 1999, 6, s. 2104-2117.

38. Riley, M. S., Porszasz, J., Miranda, J., Engelen, M. P., Brundage, B., Wasserman, K.: Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis. Chest, 111, 1997, 1, s. 44-50.

39. Rolla, G., Brussino, L., Bertero, M. T., Colagrande, P., Con-verso, M., Bucca, C., Polizzi, S., Caligaris-Cappio, F.: Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. J. Rheumatol., 24, 1997, 6, s. 1066-1071.

40. Serrano, C. D., Valero, A., Bartra, J., Roca-Ferrer, J., Muñoz-Cano, R., Sánchez-López, J., Mullol, J., Picado, C.: Nasal and bronchial inflammation after nasal allergen challenge: assessment using noninvasive methods. J. Investic. Allergol. Clin. Immunol., 22, 2012, 5, s. 351-356.

41. Silkoff, P. E., Caramori, M., Tremblay, L., McClean, P., Chaparro, C., Kesten, S., Hutcheon, M., Slutsky, A. S., Zamel, N., Keshavjee, S.: Exhaled nitric oxide in human lung transplantation. A noninvasive marker of acute rejection. Am. J. Respir. Crit. Care Med., 157, 1998, 6 Pt 1, s. 1822-1828.

42. Soderman, C., Leone, A., Furst, V., Persson, M. G.: Endogenous nitric oxide in exhaled air from patients with liver cirrhosis. Scand. J. Gastroenterol., 32, 1997, 6, s. 591-597..

43. Struben, V. M., Wieringa, M. H., Mantingh, C. J., Bommel-je, C., Don, M., Feenstra, L., de Jongste, J. C.: Nasal NO: normal values in children age 6 through to 17 years. Eur. Respir. J., 26, 2005, 3, s. 453-457.

44. Struben, V. M.,Wieringa, M. H., Mantingh, C. J., de Jong-ste, J. C.: Nasal NO measurement by direct sampling from the nose during breathold: aspiration flow, nasal resistance and reproducibility. Eur. Arch. Otorhinolaryngol., 263, 2006, s. 723-728.

45. Torretta, S., Bossi, A., Capaccio, P., Marchisio, P., Esposi-to, S., Brevi, A., Pignataro, L.: Nasal nitric oxide in children with adenoidal hypertrophy: a preliminary study. Int. J. Pediatr. Otorhinolaryngol., 74, 2010, 6, s. 689-693.

46. Zeiger, R. S., Szefler, S. J., Phillips, B. R., Schatz, M., Martinez, F. D., Chinchilli, V. M., Lemanske, R. F., Jr., Strunk, R. C., Larsen, G., Spahn, J. D. et al: Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J. Allergy Clin. Immunol., 117, 2006, 1, s. 45-52.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)

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