Detection of bronchial intraepithelial neoplasia in uranium miners by Systém Autofluorescence Endoscopy (SAFE- 1000)

Czech version

Authors: Horváth Teodor; Horváthová Marie; Salajka František ¹; Habanec Boris ²; Pafko Pavel ³; Kaňa Jindřich ⁴; Wurst František ⁵; Foretová Lenka; Koukalová Hana; Novotná Eva; Pecina Josef; Vagunda Václav; Vrbacký Roman; Talač Robert; Čoupková Helena; Pačovský Zdeněk
Authors‘ workplace: Masarykův onkologický ústav, ředitel MUDr. Josef Drbal, Žlutý kopec 7, Brno 1 Klinika nemocí plicních a tuberkulózy LF Masarykovy univerzity Brno-Bohunice, přednosta doc. MUDr. Antonín Pokorný, CSc., 2 II. patologicko-anatomický ústav FDN J. G. Mendela, B
Published in: Pracov. Lék., , 1999, No. 3, s. 114-115.
Category:

Overview

The occurrence of premalignant changes of bronchial epithelium was studied in 56 symptom-free volunteers from the risk groupof Czech and Moravian uranium miners (mean age 50.69 years, mean WLM 21.06) by the additional employment of the System ofAutofluorescence Endoscopy (SAFE-1000 Pentax) to conventional white-light bronchoscopy, comparing results with those ofbronchial biopsy histopathology examination. Histopathology using hematoxylin and eosin staining confirmed intraepithelialneoplasias in 15 areas in 10 persons. White-light bronchoscopy sensitivity was 21.05%, and specificity 93.7% which an autofluo-rescence sensitivity was 78.95%, and specificity 81.89%.1 Working Level Month (WLM) = the absorption of latent energy of 2.08 x 10 -5 J/m 3 in one month (i.e. 170 working hours).

Key words:
autofluorescence bronchoscopy, bronchial (pre-)neoplasia, bronchogenic cancer, uranium miner

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Occupational Medicine

1999 Issue 3