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proLékaře.cz / Journals / Nuclear Medicine / 2018 - 4

Assessment of 11C-methionine for PET/CT examination of patients with a brain tumor – group of 16 patients

Czech version

Authors: J. Vašina 1;  M. Svoboda 2;  R. Lakomý 2;  T. Kazda 3;  J. Adam 4;  Z. Řehák 1
Authors‘ workplace: Oddělení nukleární medicíny a PET centrum MOÚ, Brno, ČR 1;  Klinika komplexní onkologické péče MOÚ, Brno, ČR 2;  Klinika radiační onkologie MOÚ, Brno, ČR 3;  Ústav jaderného výzkumu, Řež, ČR 4
Published in: NuklMed 2018;7:62-68
Category: Original Article

Overview

Introduction:

FDG PET imaging of the brain is not ideal in patients with a brain tumor due to a high physiological accumulation of FDG in the brain tissue. These suboptimal results stimulated seeking for different radiopharmaceuticals for better imaging of brain tumors.

Goal:

To verify a possiblity of the use of 11C-methionine for evaluation of patients with brain tumors.

Method:

18 patients with brain tumors were included to the phase I clinical trial; 16 of them were evaluated, 12 had a glioblastoma, 2 an astrocytoma, 1 an oligodendroglioma and 1 a testicular tumor metastasis. PET acquisition of all patients was performed after injection of 11C-methionine at 5, 20 and 35 minutes post injection, respectively, to assess the accumulation in the tumors. Safety evaluation of injected tracer was a part of this study.

Results:

Increased accumulation of 11C-methionine in the tumor was detected in all evaluated patients; it reached 2.5fold higher values comparing to a normal brain tissue measured by a maximal value of standardized uptake value (SUVmax).

Conclusion:

11C-methionine is a useful radiopharmaceutical for the assessment of the brain tumor extent in patients with a high-grade gliomas or recurrent or progressive gliomas with a low grade in which a transformation to the high-grade gliomas can be considered.

Key words

: PET/CT, 11C-methionine, brain tumors

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Labels
Nuclear medicine Radiodiagnostics Radiotherapy
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