Current possibilities of diagnostics and treatment of immunological causes of female infertility
Authors:
Karin Malíčková 1,2; Zuzana Ambrusová 2,3; Slávka Belvončíková 4; Katarína Bergendiová 5; Zuzana Krátká 2; Martin Lešťan 4; Štěpánka Luxová 2; Jiří Novák 6; Elena Tibenská 7,8; Jana Vydláková 2,9; Lenka Sedláčková 2
Authors‘ workplace:
Klinické centrum ISCARE, a. s., Praha
1; Oddělení alergologie a klinické imunologie, GENNET, s. r. o., Praha
2; Ambulance pro alergologii a imunologii, Nemocnice s poliklinikou Mělník
3; Alergoimunologické centrum EMED, s. r. o., Prešov, SR
4; ImunoVital Centrum, Bratislava, SR
5; Centrum klinické imunologie, Nemocnice České Budějovice
6; MEDIREX, a. s., Bratislava, SR
7; Jednotka klinického výskumu, Lekárska fakulta Univerzity Komenského v Bratislave, SR
8; Ambulance klinické imunologie a alergologie, IKEM, Praha
9
Published in:
Čas. Lék. čes. 2021; 160: 5-13
Category:
Review Article
Overview
The immune system plays an important role in many processes of human reproduction. During pregnancy, mother's body has to accept the semialogenic fetus, therefore the role of immune processes has a high importance. Tolerance of the fetus by the mother's immune system is ensured by a complex of immune mechanisms, the knowledge of which brings us to the new insights into human reproduction processes and in seeking of new ways to modulate immunity in repeated embryo implantation failures, miscarriages, premature births, preeclampsia, and other fertility disorders and pregnancy complications. The review article is a summary of current possibilities of immunological laboratory diagnostics in reproductive immunology, presents indications for these tests and their interpretation, and mentions possible methods of therapeutic immune intervention.
Keywords:
infertility – Miscarriage – Immunity – In vitro fertilization – Autoantibodies – cellular immunity – NK cells – immunomodulation
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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