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Critical care for multimorbid patients


Authors: Marcela Královcová 1;  Thomas Karvunidis 1,2;  Martin Matějovič 1,2
Authors‘ workplace: Jednotka intenzivní péče, I. interní klinika, Lékařská fakulta v Plzni, Univerzita Karlova a Fakultní nemocnice Plzeň 1;  Biomedicínské centrum, Lékařská fakulta v Plzni, Univerzita Karlova 2
Published in: Vnitř Lék 2023; 69(3): 166-172
Category: Main Topic
doi: https://doi.org/10.36290/vnl.2023.029

Overview

Multimorbidity – the simultaneous presence of several chronic diseases – is very common in the critically ill patients. Its prevalence is roughly 40–85 % and continues to increase further. Certain chronic diseases such as diabetes, obesity, chronic heart, pulmonary, liver or kidney disease and malignancy are associated with higher risk of developing serious acute complications and therefore the possible need for intensive care. This review summarizes and discusses selected specifics of critical care for multimorbid patients.

Keywords:

intensive care – organ dysfunction – chronic disease – multimorbidity


Sources

1. Simpson A, Puxty K, McLoone P, et al. Comorbidity and survival after admission to the intensive care unit: A population‑based study of 41,230 patients. J Intensive Care Soc. 2021;22(2):143-51.

2. Beil M, Flaatten H, Guidet B, et al. The management of multi‑morbidity in elderly patients: Ready yet for precision medicine in intensive care? Crit Care. 2021;25(1):330.

3. Skou ST, Mair FS, Fortin M, et al. Multimorbidity. Nat Rev Dis Prim. 2022;8(1):48.

4. Nguyen H, Manolova G, Daskalopoulou C, et al. Prevalence of multimorbidity in community settings: A systematic review and meta‑analysis of observational studies. J comorbidity. 2019;9:2235042X19870934.

5. Danai PA, Moss M, Mannino DM, et al. The epidemiology of sepsis in patients with malignancy. Chest. 2006;129(6):1432-40.

6. Hodgin KE, Moss M. The epidemiology of sepsis. Curr Pharm Des. 2008;14(19):1833-9.

7. Shappell C, Rhee C, Klompas M. Update on Sepsis Epidemiology in the Era of COVID-19. Semin Respir Crit Care Med. 2023;44(1):173-84.

8. Miller PE, Thomas A, Breen TJ, et al. Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality. Am J Med. 2021;134(5):653-661.e5.

9. The Academy of Medical Sciences. Multi‑morbidity: a priority for global health research. 2018. https://acmedsci.ac.uk/fledownload/82222 577.

10. Min H, Avramovic S, Wojtusiak J, et al. A Comprehensive Multimorbidity Index for Predicting Mortality in Intensive Care Unit Patients. J Palliat Med. 2017;20(1):35-41.

11. Guidet B, de Lange DW, Boumendil A, et al. The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med. 2020;46(1):57-69.

12. Nielsen AB, Thorsen‑Meyer H‑C, Belling K, et al. Survival prediction in intensive‑care units based on aggregation of long‑term disease history and acute physiology: a retrospective study of the Danish National Patient Registry and electronic patient records. Lancet Digit Heal. 2019;1(2):e78-89.

13. Paratz J, Thomas P, Adsett J. Re‑admission to intensive care: identification of risk factors. Physiother Res Int J Res Clin Phys Ther. 2005;10(3):154-63.

14. Ho KM, Dobb GJ, Lee KY, et al. The effect of comorbidities on risk of intensive care readmission during the same hospitalization: a linked data cohort study. J Crit Care. 2009;24(1):101-7.

15. Clerencia‑Sierra M, Calderón‑Larrañaga A, Martínez‑Velilla N, et al. Multimorbidity Patterns in Hospitalized Older Patients: Associations among Chronic Diseases and Geriatric Syndromes. PLoS One. 2015;10(7):e0132909.

16. Damluji AA, Forman DE, van Diepen S, et al. Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association. Circulation. 2020;141(2):e6-32.

17. St Sauver JL, Boyd CM, Grossardt BR, et al. Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity. BMJ Open. 2015;5(2):e006413.

18. Pepper DJ, Demirkale CY, Sun J, et al. Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients. Crit Care Med. 2019;47(5):643-50.

19. Karvunidis T, Lysak D, Matejovic M. Dospely onkologicky nemocny v intenzivni peci. Je jiz cas rici „ano, zvazime to“ nez rikat „ne“?! Anesteziol a Intenziv Med [Internet]. 2017;28(6):346-53.

20. Forman DE, Maurer MS, Boyd C, et al. Multimorbidity in Older Adults With Cardiovascular Disease. J Am Coll Cardiol. 2018;71(19):2149-61.

21. Kivelitz L, Schäfer J, Kanat M, et al. Patient‑Centeredness in Older Adults With Multimorbidity: Results of an Online Expert Delphi Study. Gerontologist. 2021;61(7):1008-18.

22. McNelly AS, Flower L, Stephens TJ, et al. Attitudes of multimorbid patients to surviving future acute illness and subsequent functional disability: A systematic review. medRxiv [Internet]. 2020;1.

23. Wald R, Beaubien‑Souligny W, et al. Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury. Intensive Care Med. 2022;48(10):1368-81.

24. Boyer N, Horne K, Selby NM, et al. Renal medicine in the intensive care unit: a narrative review. Anaesthesia. 2023; 11; doi:10.1111/anae.15964.

25. Singer P, Blaser AR, Berger MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38(1):48-79.

26. Compher C, Bingham AL, McCall M, et al. Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2022;46(1):12-41.

27. Joshi N, Caputo GM, Weitekamp MR, et al. Infections in patients with diabetes mellitus. N Engl J Med. 1999;341(25):1906-12.

28. Graham BB, Keniston A, Gajic O, et al. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med. 2010;38(1):16-24.

29. Stegenga ME, Vincent J‑L, Vail GM, et al. Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med. 2010;38(2):539-45.

30. Vincent J‑L, Preiser J‑C, Sprung CL, et al. Insulin‑treated diabetes is not associated with increased mortality in critically ill patients. Crit Care. 2010;14(1):R12.

31. Michalia M, Kompoti M, Koutsikou A, et al. Diabetes mellitus is an independent risk factor for ICU‑acquired bloodstream infections. Intensive Care Med. 2009;35(3):448-54.

32. Freire AX, Bridges L, Umpierrez GE, et al. Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest. 2005;128(5):3109-16.

33. Whitcomb BW, Pradhan EK, Pittas AG, et al. Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med. 2005;33(12):2772-7.

34. Esper AM, Moss M, Martin GS. The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study. Crit Care. 2009;13(1):R18.

35. Ali NA, O’Brien JMJ, Dungan K, et al. Glucose variability and mortality in patients with sepsis. Crit Care Med. 2008;36(8):2316-21.

36. Krinsley JS. Glycemic variability and mortality in critically ill patients: the impact of diabetes. J Diabetes Sci Technol. 2009;3(6):1292-301.

37. Hermanides J, Vriesendorp TM, Bosman RJ, et al. Glucose variability is associated with intensive care unit mortality. Crit Care Med. 2010;38(3):838-42.

38. Boord JB, Graber AL, Christman JW, et al. Practical management of diabetes in critically ill patients. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1763-7.

39. Anderson MR, Shashaty MG. Impact of Obesity in Critical Illness. Chest. 2021;160(6):2135-45.

Další literatura u autora

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Labels
Diabetology Endocrinology Internal medicine
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