-
Medical journals
- Career
Differential dignosis: „primary“ or secondary diabetes – should Cushing´s syndrome be routinely screened in the patients with type 2 diabetes mellitus?
Authors: Karolína Melicharová 1; Ludmila Brunerová 2; Jana Urbanová 2; Jan Brož 1
Authors‘ workplace: Interní klinika FN Motol a 2. LF UK, Praha 1; Interní klinika FNKV a 3. LF UK, Praha 2
Published in: Vnitř Lék 2021; 67(E-3): 8-10
Category: Review Articles
Overview
Cushing´s syndrome is a rare disease with the population prevalence about 40 patients per 1 million inhabitants, the number among patients with diabetes mellitus (DM) is probably higher. The screening of CS among the DM patients showed the prevalence between 0–2.9% in the groups of outpatients and 2–2.9% among the patients admitted to the hospital at the time of randomization. The routine screening of CS among patients with type 2 DM is not recommended at the moment. Nevertheless, the possibility of CS should be taken into the account mainly in patients with hypertension, obesity, microvascular complications, bad level of metabolic control or high insulin doses, especially, if more of these features are present. A hormonal profile of patients with adrenal incidentaloma should be evaluated.
Keywords:
Cushing´s syndrom – diabetes mellitus – screning – adrenal incidentaloma
Sources
1. Kršek M. Cushingův syndrom. 2013; Interní medicína pro praxi 2013; 15 : 368–371.
2. Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, John Newell-Price, Martin O. Savage, Paul M. Stewart, Victor M. Montori, The Diagnosis of Cushing‘s Syndrome: An Endocrine Society Clinical Practice Guideline, JCEM 2008; 93(5): 1526–1540. https://doi. org/10.1210/jc.2008-0125.
3. Hsieh LB, Mackinney E, Wang TS. When to Intervene for Subclinical Cushing‘s Syndrome. Surg Clin North Am. 2019; 99(4): 747–758.
4. Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing‘s syndrome. Lancet. 2015; 386 : 913–927.
5. Castinetti F, Morange I, Conte-Devolx B, Brue T. Cushing‘s disease. Orphanet J Rare Dis. 2012; 7 : 41.
6. Rubinstein G, Osswald A, Hoster E et al. Time to Diagnosis in Cushing‘s Syndrome: A Meta-Analysis Based on 5367 Patients. J Clin Endocrinol Metab. 2020; 105(3): dgz136.
7. Javanmard P, Duan D, Geer EB. Mortality in Patients with Endogenous Cushing‘s Syndrome. Endocrinol Metab Clin North Am. 2018; 47(2): 313–333.
8. Petramala L, Olmati F, Concistrè A, et al. Cardiovascular and metabolic risk factors in patients with subclinical Cushing [published online ahead of print, 2020 Apr 16]. Endocrine. 2020;10.1007/s12020-020-02297-2. doi:10.1007/s12020-020-02297-2.
9. Barbot M, Ceccato F, Scaroni C. Diabetes Mellitus Secondary to Cushing‘s Disease. Front Endocrinol (Lausanne). 2018; 9 : 284.
10. Kršek M. Poruchy metabolizmu cukrů u Cushingova syndromu. Forum Diabetologicum. 2014; 3 : 123–127.
11. Cansu GB, Atılgan S, Balci MK et al. Which type 2 diabetes mellitus patients should be screened for subclinical Cushing‘s syndrome? Hormones (Athens). 2017; 16 : 22–32.
12. Chiodini I, Torlontano M, Scillitani A et al. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol. 2005; 153 : 837–844.
13. Gungunes A, Sahin M, Demirci T et al. Cushing‘s syndrome in type 2 diabetes patients with poor glycemic control. Endocrine. 2014; 47 : 895–900.
14. Reimondo G, Castellano E, Grosso M et al. Adrenal Incidentalomas are Tied to Increased Risk of Diabetes: Findings from a Prospective Study. J Clin Endocrinol Metab. 2020; 105(4): dgz284.
Labels
Diabetology Endocrinology Internal medicine
Article was published inInternal Medicine
2021 Issue E-3-
All articles in this issue
- Rituximab in the treatment of primary glomerulopathies – our experience
- Differential dignosis: „primary“ or secondary diabetes – should Cushing´s syndrome be routinely screened in the patients with type 2 diabetes mellitus?
- Biomarker GDF-15 in cardiology
- Transformation of IgM-MGUS into Waldenström´s macroglobulinemia in two of six patients treated for Schnitzler´s syndrome
- Recurrent respiratory arrests – an unusual manifestion of SLE
- Liver cirrhosis and pregnancy: a case report and review of literature
- How can a diabetologist help a patient after ischemic stroke?
- COVID-19 patient care experience in the United Kingdom
- Legal aspects of intestinal microbiome application
- Evropský a světový kongres o hypertenzi 2021
- Internal Medicine
- Journal archive
- Current issue
- Online only
- About the journal
Most read in this issue- Liver cirrhosis and pregnancy: a case report and review of literature
- Biomarker GDF-15 in cardiology
- Recurrent respiratory arrests – an unusual manifestion of SLE
- Rituximab in the treatment of primary glomerulopathies – our experience
Login#ADS_BOTTOM_SCRIPTS#Forgotten passwordEnter the email address that you registered with. We will send you instructions on how to set a new password.
- Career