#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hospital-acquired methemoglobinemia


Authors: Jan Táborský 1;  Martin Střelka 1;  Marcela Káňová 2;  Zdeněk Kořístek 3;  Šárka Blahutová 3;  Roman Černohorský 1;  Tomáš Mičkal 1
Authors‘ workplace: Interní oddělení Nemocnice Nový Jičín, a. s. 1;  Klinika anesteziologie, resuscitace a intenzivní medicíny LF OU a FN Ostrava 2;  Klinika hematoonkologie LF OU a FN Ostrava 3
Published in: Vnitř Lék 2020; 66(6): 46-52
Category: Case Report

Overview

Methemoglobinemia is rare condition of hem iron. Ferrous form iron (Fe2+) is oxidised to Ferric form (Fe3+). Methemoglobin has reduced ability to release oxygen to tissues and thereby leads to tissue hypoxia. We present case of patient with methemoglobinemia of unknown etiology. Methemoglobinemia developed during hospitalization. Diferent causes of methemoglobinemia and also a treatment possibilities are discussed. 

Keywords:

ascorbic acid,  local anesthetic – methemoglobinemia – Methylene blue


Sources

1. Bradberry SM. Occupational methaemoglobinaemia mechanisms of production, features, diagnosis and management including the use of methylene blue. Toxicol Rev 2003; 22: 13–17.

2. Song P, Li X, Yan Y. Analysis of the literature on acute aromatic amino or nitro-compounds poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2014; 32: 366–369.

3. Shatila W, Verma A, Adam S. Plasmapheresis in severe methemoglobinemia following occupational exposure. Transfusion and Apheresis Science 2017; 56: 341–344.

4. Souza do Nascimento T, Otávio Lami Pereira R, Luiz Dias de MelloH, et al. Methemoglobinemia: from diagnosis to treatment. Rev Bras Anestesiol 2008; 58: http://dx.doi. org/10.1590/S0034-70942008000600011

5. Richard Alyce M, Diaz James H, Kaye AD. Reexamining the Risks of Drinking-Water Nitrates on Public Health. The Ochsner Journal 2015; 14: 392–398.

6. Gian M, Novaro MD, Herbert D, et al. Benzocaine-induced methemoglobinemia: Experience from a high-volume transesophageal echocardiography laboratory. J Am Soc Echocardiogr 2003; 16: 170–175.

7. Kane GC, Hoehn SM, Behrenbeck TR, et al. Benzocaine-Induced Methemoglobinemia Based on the Mayo Clinic Experience From 28 478 Transesophageal Echocardiograms: Incidence, Outcomes, and Predisposing Factors. Arch Intern Med 2007; 167: 1977–1982.

8. Mutlu M, Erduran E, Aslan Y. Acquired methemoglobinemia in infants. Turk J Haematol 2011; 28: 131–134.

9. Barash M, Reich KA, Rademaker D. Lidocaine-induced methemoglobinemia: a clinical reminder. J Am Osteopath Assoc 2015; 115: 94–98.

10. Ohashi K, Yukioka H, Hayashi M, et al. Elevated methemoglobin in patients with sepsis. Acta Anaesthesiol Scand 1998; 42: 713–716.

11. Carlson DJ, Shapiro FL. Methemoglobinemia from Well Water Nitrates: A Complication of Home Dialysis. Ann Intern Med 1970; 73: 757–759.

12. de Torres JP, Strom JA, Jaber BL, et al. Hemodialysis-associated methemoglobinemia in acute renal failure. Am J Kidney Dis 2002; 39: 1307–1309.

13. Medarov BI, Pahwa S, Reed S, et al. Methemoglobinemia Caused by Portable Dialysis in the Critically. Crit Care Med 2017; 45: e232–e235.

14. Skold A, Cosco DL, Klein R. Methemoglobinemia: pathogenesis, diagnosis, and management. South Med J 2011; 104: 757–761.

15. Sievers RF, Ryon JB. Congenital idiopathic methemoglobinemia: favourable response to ascorbic acis therapy. Arch Intern Med (Chic) 1945; 76: 299–307. doi:10.1001/archinte.1945.00210350045007

16. Cortazzo JA, Lichtman AD. Methemoglobinemia: a review and recommendations for management. J Cardiothorac Vas Anesth 2014; 28: 1043–1047.

17. Faust AC, Guy E, Baby N. Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. J Emerg Med 2018; 54: 681–684.

18. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999; 34: 646–656.

19. Toker I, Yesilaras M, Tur FC, et al. Methemoglobinemia caused by dapsone overdose: Which treatment is best? Turk J Emerg Med 2016; 15: 182–184.

20. Waller HD, Benöhr HC, Tigges FJ. On the mechanism of ascorbic acid induced methemoglobin reduction of human erythrocytes. Klin Wochenschr 1977; 55: 955–964.

21. Balwani MR, Bawankule CP, Ramteke V, et al. Methylene Blue Induced Methemoglobinemia with Acute Kidney Injury in a Glucose-6-Phosphate Dehydrogenase-deficient Patient. Indian J Nephrol 2017; 27: 465–467.

22. Methylthioninium chloride Proveblue 5 mg/ml solution for injection, SPC, dostupné z https://www.ema.europa.eu

23. Prchal JT. Clinical Features, Diagnosis, and Treatment of Methemoglobinemia. UpToDate Web site http://www.uptodate.com/contents/clinical-features-diagnosis-and-treatment-of-methemoglobinemia; Accessed 12.02.14

24. Hoffman RS, Nelson LS, Howland MA (eds.). Goldfrank’s Manual of Toxicologic Emergencies. The McGraw-Hill Companies, Inc; 2007: 977–985.

25. Hunter L, Gordge Ldargan PI, Wood DM. Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: A review. Br J Clin Pharmacol 2011; 72: 18–26.

26. Patnaik S, Natarajan MM, James EJ, et al. Methylene blue unresponsive methemoglobinemia. Indian J Crit Care Med 2014; 18: 253–255.

27. Lockhart V, Ong M. 367 Red Blood Cell Exchange for Treatment of Acquired Methemoglobinemia in a Hospitalized Patient: A Case Report. American Journal of Clinical Pathology 2018; 149: S159–S160.

28. Khetarpal A, Kotwal U. Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience. Indian J Hematol Blood Transfus 2018; 34: 143–145.

29. Alanazi M. Drugs may be Induced Methemoglobinemia. Journal of Hematology & Thromboembolic Diseases 2017; 10.4172/2329-8790.1000270.

30. Mark Barash DO, Keith AR, Rademaker D. Lidocaine-Induced Methemoglobinemia: A Clinical Reminder. The Journal of the American Osteopathic Association 2015; 115: 94–98.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue 6

2020 Issue 6

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#