Takotsubo syndrome

Czech version

Authors: Karolína Poledníková; Petr Toušek
Authors‘ workplace: III. interní – kardiologická klinika 3. LF UK a FN Královské Vinohrady, Praha
Published in: Vnitř Lék 2019; 65(10): 659-662
Category:

Overview

Takotsubo syndrome (TTS) is currently regarded as a special type of acute coronary syndrome. The syndrome can be trigerred by emotional stress factors and more often by some severe non-cardiac conditions. The long-term outcome of TTS patients is similar to those with myocardial infarction. The exact pathophysiological mechanism is not yet fully explained. Excessive amount of catecholamines released into bloodstream after stress attack plays a crucial role. The transient left ventricle dysfunction is probably caused by combination of several pathophysiological mechanism. There is little data concerning the treatment of TTS. It is important to focus on therapeutic strategies in order to eliminate risk of heart failure or TTS recurrence. The aim of the present review is to bring last known information about this disease.

Keywords:

outcome – pathophysiological mechanism – takotsubo syndrome (TTS) – treatment

Sources

Sato H. Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Kodama K, Haze K, Hori M (eds). Clinical Aspect of Myocardial Injury: from Ischemia to Heart Failure. Tokyo: Kagakuhyoronsha Publishing 1990 : 56–64.
Pelliccia F, Sinagra G, Elliott P et al. Takotsubo is not a cardiomyopathy. Int J Cardiol 2018; 254 : 250–253. Dostupné z DOI: <http://doi: 10.1016/j.ijcard.2017.12.009>.
Ghadri JR, Wittstein IS, Prasad A et al. International expert consensus document on Takotsubo syndrome (part i): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J 2018; 39(22): 2032–2046. Dostupné z DOI: <http://doi: 10.1093/eurheartj/ehy076>.
Ghadri JR, Sarcon A, Diekmann J et al. Happy heart syndrome: role of positive emotional stress in takotsubo syndrome. Eur Heart J 2016; 37(37): 2823–2829. Dostupné z DOI: <http://doi: 10.1093/eurheartj/ehv757>.
Ghadri JR, Kato K, Cammann VL et al. Long-Term Prognosis of Patients with Takotsubo Syndrome. J Am Coll Cardiol 2018; 72(8): 874–882. Dostupné z DOI: <http://doi: 10.1016/j.jacc.2018.06.016>.
Wittstein IS, Thiemann DR, Lima JA et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005; 352(6): 539–548. Dostupné z DOI: <http://doi: 10.1056/NEJMoa043046>.
Pelliccia F, Kaski JC, Crea F et al. Pathophysiology of Takotsubo Syndrome. Circulation 2017; 135(24): 2426–2441. Dostupné z DOI: <http://doi: 10.1161/CIRCULATIONAHA.116.027121>.
Templin C, Hänggi J, Klein C et al. Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome. Eur Heart J 2019; 40(15): 1183–1187. Dostupné z DOI: <http://doi: 10.1093/eurheartj/ehz068>.
Templin C, Ghadri JR, Diekmann J et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N Engl J Med 2015; 373(10): 929–938. Dostupné z DOI: <http://doi: 10.1056/NEJMoa1406761>.
Scally C, Rudd A, Mezincescu A et al. Persistent Long-Term Structural, Functional, and Metabolic Changes after Stress-Induced (Takotsubo) Cardiomyopathy. Circulation 2017; 137(10): 1039–1048. Dostupné z DOI: <http://doi: 10.1161/CIRCULATIONAHA.117.031841>.
Ghadri JR, Cammann VL, Templin C et al. International Takotsubo (InterTAK) Registry. Differences in the Clinical Profile and Outcomes of Typical and Atypical Takotsubo Syndrome: Data from the International Takotsubo Registry. JAMA Cardiol 2016; 1(3): 335–340. Dostupné z DOI: <http://doi: 10.1001/jamacardio.2016.0225>.
Komamura K, Fukui M, Iwasaku T et al. Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment. World J Cardiol 2014; 6(7): 602–609. Dostupné z DOI: <http://doi: 10.4330/wjc.v6.i7.602>.
Padayachee L. Levosimendan: the inotrope of choice in cardiogenic shock secondary to takotsubo cardiomyopathy? Heart Lung Circ 2007; 16(Suppl 3): S65-S70. Dostupné z DOI: <http://doi: 10.1016/j.hlc.2007.03.018>.