Vliv chirurgické léčby na kvalitu života u pacientů s Crohnovou chorobou: finální výsledky české kohorty
Authors:
Lumír Kunovský 1,2; Ladislav Mitas 1; Filip Marek 1; Jiri Dolina 2; Karolina Poredska 2; Lenka Kucerova 2; Klara Benesova 3,4; Zdeněk Kala 1
Authors‘ workplace:
Department of Surgery, University Hospital Brno, Medicine of adult age (Bohunice), and Faculty of Medicine, Masaryk University, Brno, Czech Republic
1; Department of Gastroenterology, University Hospital Brno, Medicine of adult age (Bohunice), and Faculty of Medicine, Masaryk University, Brno, Czech Republic
2; Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3; Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
4
Published in:
Vnitř Lék 2018; 64(4): 347-354
Category:
Original Contributions
Overview
Úvod:
Crohnova nemoc (Crohn´s disease – CD) patří mezi chronické onemocnění, které značně ovlivňuje kvalitu života (quality of life – QoL) u těchto pacientů. Cílem studie bylo stanovit, jaký vliv má chirurgická léčba na kvalitu života (quality of life – QoL) u pacientů s CD a určit faktory, které ovlivňují pooperační QoL.
Metody a pacienti:
Porovnávána byla QoL před operací a v pooperačním období u pacientů, kteří podstoupili na Chirurgické klinice střevní resekci z indikace CD v letech 2010–2016. Pacienti vyplnili standardizovaný dotazník k měření QoL QLQ-CR29 v předoperačním období a po operaci s odstupem 2 měsíců. Kontrolní skupiny představovali pacienti s CD, kteří nepodstoupili chirurgickou léčbu (resekci střeva) a zcela zdravá kohorta osob. Do studie bylo celkem zahrnuto 132 operovaných pacientů pro CD (resekce střeva), 83 pacientů s CD bez operace a 104 zdravých jedinců.
Výsledky:
Pooperační zlepšení QoL bylo zjištěno celkem u 104 operovaných pacientů (78,8 %), u 2 pacientů nebyla zaznamenána žádná změna v QoL (1,5 %) a u 26 pacientů (19,7 %) bylo zjištěno zhoršení pooperační QoL. Výsledky byly statisticky signifikantně významné (p < 0,001).
Závěr:
Prokázali jsme signifikantní zlepšení celkové QoL po střevní resekci u pacientů s CD v měřeném intervalu 2 měsíce od operace. Pohlaví bylo vyhodnoceno jako jediný statisticky významný faktor ovlivňující pooperační QoL
Klíčová slova:
Crohnova choroba – česká kohorta – chirurgická léčba – idiopatické střevní záněty – kvalita života – resekce střeva
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