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Autoantibodies in systemic connective tissue disease and ANCA-associated vasculitis, their relationship to interstitial lung diseases and prognosis


Authors: Martina Doubková 1;  Jana Pokorná 2
Authors‘ workplace: Klinika nemocí plicních a tuberkulózy LF MU a FN Brno, pracoviště Bohunice 1;  Laboratoř autoimunitní diagnostiky Dermatovenerologického oddělení LF MU a FN Brno, pracoviště Bohunice 2
Published in: Vnitř Lék 2017; 63(2): 98-106
Category: Reviews

Overview

Lung disease, including interstitial lung disease (ILD), is a frequent complication of systemic connective tissue disorders (CTD) and ANCA (anti-neutrophil cytoplasmic antibody) associated vasculitis (AAV). Pulmonary manifestations are prognostic factor of CTDs and vasculitis. Autoantibodies assessment is a part of differential diagnosis algorithm of lung diseases. Autoantibodies importance is mainly clinical-diagnostic. Using detection of some autoantibodies it is possible to determine prognosis of lung involvement, especially in CTDs.

Key words:
autoantibodies – connective tissue disease – interstitial lung diseases – prognosis – vasculitis


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