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Non-pharmacological treatment – results from Poděbrady


Authors: Lukáš Zlatohlávek 1;  Michal Vrablík 1;  Zuzana Urbanová 2;  Hana Pejšová 1;  Jaroslav Hubáček 3;  Richard;  Češka 1
Authors‘ workplace: III. interní klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA 1;  Klinika dětského a dorostového lékařství 1. LF UK a VFN Praha, přednosta prof. MUDr. Jiří Zeman, DrSc. 2;  Laboratoř molekulární genetiky IKEM Praha, přednosta MUDr. Jan Piťha, CSc. 3
Published in: Vnitř Lék 2014; 60(11): 958-962
Category: Reviews

Overview

Objectives:
The study was aimed to determine risk factors of atherosclerosis after one month lifestyle intervention in overweight/obese children and also FTO and MC4R gene variants associated with obesity.

Design and Methods:
350 non-diabetic Czech children (age 13.7 ± 2.1 years, 163 ± 10.6 cm hight) was examined. Before and after 4 weeks of lifestyle intervention (comprising a reduction of energy intake), biochemical and anthropometrical measurements were performed.

Results:
The mean weight loss achieved was 6.2 ± 2.1 kg (P < 0.001). Significant associations between BMI decrease and FTO and MC4R variants were found. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to the non-carriers (P < 0.0009 for BMI and P < 0.002 for body weight). The differences remain significant after adjustment for sex age and baseline values (P = 0.004 for BMI and P = 0.01 for body weight).

Conclusions:
It is necessary to look for the risk individuals with wrong response to the regime intervention. This individuals is necessary early treat with drugs to prevention clinically complications.

Key words:
childhood obesity – components of metabolic syndrome – predisposition – response to intervention


Sources

1. Zlatohlávek L, Urbanová Z, Vrablík M et al. Sledování faktorů aterokslerózy u obézních dětí. Čes-Slov Pediat 2011; 66(3): 153–156.

2. Šamánek M, Urbanová Z Výskyt nadváhy a obezity u 7 427 českých dětí vyšetřených v roce 2006. Čes-Slov Pediat 2008; 63(3): 120–126.

3. Hubacek JA, Pikhart H, Peasey A et al. FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study. Physiol Res 2011; 60(1): 175–183.

4. Haupt A Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss. Obesity (Silver Spring) 2009; 17(10): 1942–1945.

5. Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40(6): 768–765.

6. Hubacek JA, Pitha J, Adamkova V et al. A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies. Clin Chem Lab Med 2009; 47(4): 387–390.

7. Dlouhá D, Suchánek P, Lánská V et al. Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms. Physiol Res 2011; 60(1): 199–202.

Labels
Diabetology Endocrinology Internal medicine
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