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Alcoholic cardiomyopathy – still a topical diagnosis


Authors: P. Kyčina 1;  J. Murín 2
Authors‘ workplace: Interné oddelenie - Jednotka intenzívnej starostlivosti Liptovskej nemocnice Liptovský Mikuláš, Slovenská republika, prednosta prim. MUDr. Viliam Iľanovský 1;  I. interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenská republika, prednostka doc. MUDr. Soňa Kiňová, PhD. 2
Published in: Vnitř Lék 2011; 57(2): 163-169
Category: Reviews

Overview

Even though extensive experimental as well as clinical evidence exists for adverse cardiac effects of alcohol, pathogenesis and incidence of alcoholic cardiomyopathy is not fully understood. From the genetic level and understanding of the pathogenesis of the toxic effects of alcohol on the heart we come to discuss the diagnosis and treatment of the disease that, in the context of co-morbidities and complications (hypertension, diabetes, arrhythmias, heart failure), continues to represent an significant clinical entity with an important impact on patient prognosis.

Key words:
alcohol – alcoholic cardiomyopathy – complications – prognosis


Sources

1. Widimský J, Víšek V. Preventivní kardiologie. Praha: Avicenum 1981: 213–217.

2. Piano MR. Alcoholic cardiomyopathy: incidence, clinical characteristics and pathophysiology. Chest 2002; 121: 1638–1650.

3. Maron BJ, Towbin JA, Thiene G et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006; 113: 1807–1816.

4. Remme WJ, Swedberg K. Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 2001; 22: 1527–1560.

5. Piano MR. Alcohol and heart failure. J Card Fail 2002; 8: 239–244.

6. Fauchier L, Babuty D, Poret P et al. Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy. Eur Heart J 2000; 21: 306–314.

7. Nicolás JM, Fernández-Solà J, Estruch R et al. The effect of controlled drinking in alcoholic cardiomyopathy. Ann Intern Med 2002; 136: 192–200.

8. Rusnák I, Žuffa M, Pullmann R et al. Validita laboratórnych vyšetrení pre diagnostiku alkoholizmu a alkoholických poškodení pečene. Vnitř Lék 1991; 37: 578–584.

9. Gvozdjáková A. Metabolické zmeny v myokarde po podávaní etanolu. Rigorózna práca. Bratislava 1972.

10. Kyčina P. Alkoholová kardiomyopatia – stanovenie vybraných funkčných a morfologických parametrov srdca echokardiograficky vzhľadom ku kvantite, kvalite a dobe konzumu alkoholu. Cardiology 2008; 17 (Suppl 2): 19S–20S.

11. Moushmoush B, Abi-Mansour P. Alcohol and the heart. Arch Intern Med 1991; 151: 36–40.

12. Nicolas S, Aberle I. Experimental assesment of the role of Acetaldehyde in Alcoholic Cardiomyopathy. Available from: http://www.biologicalprocedures.com/bpo/arts/1/412004.

13. Gregor P, Widimský P. Kardiologie v praxi. Praha: Galén 1999.

14. Niederle P. Echokardiografie dospělých. Praha: Triton 2002.

15. Silvestry FE, Popjes E. Alcoholic Cardio­myopathy. Emedicine J 2002; 3. Available from: http://www.emedicine.com/med/topic286.htm.

16. Farský Š, Lepej J, Bakos K. Nukleárna kardiológia. Martin: Osveta 1989.

17. Zima T, Mareček Z, Špičák J et al. Poškození jater, pankreasu a trávicího ústrojí alkoholem. Praha: Medprint 1996: 7–14.

18. Gvozdják J, Gvozdjáková A, Kucharská J et al. Novšie poznatky o kardiomyopatiách. Bratisl Lek Listy 1994; 95: 389–390.

19. Ehrman J. Alkohol a játra. Lék Listy 2003; 48: 11.

20. Kolbel F. Charakteristika a výskyt kardio­myopatií. Novinky v medicíně. Praha: Avicenum 1981.

21. Riečanský I. Srdcové zlyhanie. Bratislava: Herba 1998.

22. Fernández-Solà J, Nicolás JM, Oriola J et al. Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. Ann Intern Med 2002; 137: 321–326.

23. Duan J, McFadden GE, Borgerding AJ et al. Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes. Am J Physiol Heart Circ Physiol 2002; 282: H1216–H1222.

24. Fernández-Solà J, Nicolás JM, Oriola J et al. Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. Ann Intern Med 2002; 137: 321–326.

25. Richardson P, McKenna W, Bristow M et al. Report of the 1995 WHO/ISH task force on the definition and classification of cardio­myopaties. Circulation 1996; 93: 841–842.

26. National Institute on Alcohol Abuse and Alcoholism. Alcohol and cardiovascular system. Available from: http://www.niaaa.nih.gov/extramural/acs.htm.

27. Wakabayashi I, Kobaba-Wakabayashi R, Masuda H. Relation of drinking alcohol to atherosclerosis risk in type 2 diabetes. Diabetes Care 2002; 25: 1223–1228.

28. Ďuriš I, Hulín I, Bernadič M. Princípy internej medicíny. Bratislava: Slovak Academic Press 2001.

29. Gregor P, Widimský P. Kardiologie. Praha: Galén 1999.

30. Donohue TM Jr. The ubiquitin-proteasome system and is role in ethanol-induced disorders. Addict Biol 2002; 7: 15–28.

31. Guertl B, Noehammer C, Hoefler G. Metabolic cardiomyopathies. Int J Exp Pathol 2000; 81: 349–372.

32. Lee WK, Regan TJ. Alcoholic cardiomyopathy: is it dose-dependent? Congest Heart Fail 2002; 8: 303–306.

33. Dettmeyer R, Reith K, Madea B. Alcoholic cardiomyopathy versus chronic myocarditis – immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic Sci Int 2002; 126: 57–62.

34. Lazarini L, Ghio S. Echocardiographic evolution of left ventricular and left atrial thrombi in a patient with left ventricular dysfunction due to alcoholic cardiomyopathy, chronic atrial fibrillation and multiple non-fatal systemic embolisms. Acta Cardiol 2001; 56: 131–135.

35. Schoppet M, Maisch B. Alcohol and the heart. Herz 2001; 26: 345–352.

36. Fernández-Solà J, Estruch R, Nicolás JM et al. Comparison of alcoholic cardiomyopathy in women versus men. Am J Cardiol 1997; 80: 481–485.

37. Klatsky AL. Moderate drinking and reduced risk of heart disease. Alcohol Res Health 1999; 23: 15–23.

38. Ajani UA, Gazino JM, Lotufo PA et al. Alcohol consumption and risk of coronary heart disease by diabetes status. Circulation 2000; 102: 500–505.

39. Solomon CG, Hu FB, Stampfer MJ et al. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation 2000; 102: 494–499.

40. Novotný V, Heretik A, Heretik A  ml. et al. Epidemiológia alkoholizmu vo svete a na Slovensku. Lek Obzor 2010; 41: 103.

41. Hlásenský V. Magické myšlení: jsem lékař, ne pacient. Zdravotnické noviny 2003; 48: 17.

42. Johnson K. Moderate drinking may help acute MI survival. Fam Pract News 2000. Available from: http://www.findarticles.com.

43. Gavazzi A, De Maria R, Parolini M et al. Alcohol abuse and dilated cardiomyopathy in men. Am J Cardiol 2000; 85: 1114–1118.

44. Šamánek M. Každodenní pití malého množství alkoholu je zdraví prospěšné. Cor Vasa 2004; 46: 97–99.

45. Braunwald E. Heart Disease. 6th ed. Philadelphia, Toronto, London: W.B. Saunders Company 2001.

46. Klabník A, Murín J, Kyčina P. Do we need new quality markers for chronic heart failure? Bratisl Lek Listy 2010; 111: 392–397.

47. Ehrmann J, Schneiderka P, Ehrmann J. Alkohol a játra. Praha: Grada Publishing 2006: 138–139.

48. Kupari M. Reversibility of alcoholic cardiomyopathy. Postgrad Med J 1984; 60: 151–154.

49. Corović N, Duraković Z, Misigoj-Duraković M. Dispersion of the corrected QT and JT interval in the electrocardiogram of alcoholic patients. Alcohol Clin Exp Res 2006; 30: 150–154.

50. Lang CH, Frost RA, Summer AD et al. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Int J Biochem Cell Biol 2005; 37: 2180–2195.

51. Morton A. Pregnancy outcome in a mother with alcoholic cardiomyopathy. Aust N Z J Obstet Gynaecol 2005; 45: 328–330.

52. Li Q, Ren J. Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase. Alcohol Alcohol 2006; 41: 585–592.

53. Oba T, Maeno Y, Ishida K. Differential contribution of clinical amounts of acetaldehyde to skeletal and cardiac muscle dysfunction in alcoholic myopathy. Curr Pharm Des 2005; 11: 791–800.

54. Djoussé L, Gaziano JM. Alcohol consumption and heart failure in hypertensive US male physicians. Am J Cardiol 2008; 102: 593–597.

55. Poloncová E. Prehľady a štatistiky za okres Liptovský Mikuláš. Štátny zdravotný ústav Liptovský Mikuláš 2003.

56. Møller S, Henriksen JH. Cardiovascular complications of cirrhosis. Postgrad Med J 2009; 85: 44–54.

57. Trejbal K, Mitro P. ECG changes in alcoholic intoxication. Vnitř Lék 2008; 54: 410–414.

58. Djoussé L, Gaziano M. Alcohol consumption and heart failure: a systematic review. Curr Atheroscler Rep 2008; 10: 117–120.

59. Costanzo S, Di Castelnuovo A, Donati MB et al. Cardiovascular and overall mortality risk in relation to alcohol consumption in patients with cardiovascular disease. Circulation 2010; 121: 1951–1959.

60. Klatsky AL. Alcohol and cardiovascular mortality: common sense and scientific truth. J Am Coll Cardiol 2010; 55: 1336–1338.

61. Mukamal KJ, Chen CM, Rao SR et al. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol 2010; 55: 1328–1335.

62. Zardi E, Abbate A, Dobrina A et al. Cirrhotic cardiomyopathy. J Am Coll Cardiol 2010; 56: 539–549.

63. Jensen M, Mukamal K, Overvad K et al. Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur Heart J 2008; 29: 104–112.

64. Janszky I, Ljung R, Ahnve S et al. Alcohol and long-term prognosis after a first acute myocardial infarction: the SHEEP study. Eur Heart J 2008; 29: 45–53.

65. Vavrušová L. Miesto silymarínu v liečbe alkoholového poškodenia pečene. Súč Klin Prax 2009; 2: 21–24.

66. Trejbal K. Alkohol a poruchy srdcového rytmu. Intern Med 2010; 10: 432–436.

67. Feszterová M, Kašiarová S. Influence of climate conditions and air contaminations on village inhabitants health. 4th Meeting on chemistry and life. Chemické listy 2008; 102: 300–302.

68. O’Keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 2007; 50: 1009–1014.

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