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Clinical Studies That Have Influenced the Treatment of Diabetes
Authors: J. Olšovský
Authors‘ workplace: Diabetologické centrum II. interní kliniky Lékařské fakulty MU a FN u sv. Anny Brno, přednosta prof. MUDr. Miroslav Souček, CSc.
Published in: Vnitř Lék 2009; 55(4): 349-353
Category:
Overview
In the article, the author addresses the development of the targets of diabetes treatment. He provides an overview of the key clinical studies in diabetology from which we draw knowledge and therapeutical recommendations nowadays, i.e. in the times of evidence‑based medicine. The author emphasizes the need for comprehensive treatment of diabetes, i.e. the treatment of obesity, hypertension, dyslipidemia and also the impact on blood coagulation, however, focuses, in particular, on clinical studies focusing on the influence of diabetes compensation (the impact on hyperglycemia) on the development of vascular complications.
Key words:
diabetes mellitus – hyperglycemia – vascular complications – clinical studies
Sources
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3. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352 : 837–853.
4. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ 1998; 317 : 703–713.
5. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group. BMJ 1998; 317 : 713–720.
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9. Kahn SE, Haffner SM, Heise MA et al. For the ADOPT Study Group. Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherap. N Eng J Med 2006; 355 : 2427–2443.
10. ACCORD, Gerstein HC, Miller ME et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358 : 2545–2559.
11. ADVANCE collaboration Group, Patel A, MacMahon S et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358 : 2560–2572.
12. Rationale and design of the ADVANCE study. J Hypertens 2001; 19 (Suppl 4): S21–S28.
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Labels
Diabetology Endocrinology Internal medicine
Article was published inInternal Medicine
2009 Issue 4-
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