Antiphospholipid syndrome – diagnosis and treatment

Czech version

Authors: A. Buliková; M. Penka
Authors‘ workplace: Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc.
Published in: Vnitř Lék 2005; 91(7 a 8): 809-817
Category: 128th Internal Medicine Day - 21rd Vanysek's Day Brno 2005

Overview

Antiphospoholid syndrome is the most common form of acquired thrombophilia. It can cause significant morbidity and even mortality. Any organ system and any size of vessel can be affected during clinical course of the disease. Therefore, the antiphospholipid syndrome can manifest itself in a wide variety of clinical features. Despite advances in the understanding of the pathogenesis of antiphospholipid antibodies impact on their target structures, the mainstay of management is still anticoagulation. In this review, we focused on diagnostic procedure in patients with antiphospholipid antibodies and we summarised therapeutic approaches.

Key words:
antiphospholipid syndrome – diagnostic procedure – treatment

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