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Pleiotropic effect of citalopram in geriatric patiens


Authors: T. Richter;  Z. Paluch
Authors‘ workplace: Geriatrická klinika 1. LF UK a VFN, Praha 1;  Farmakologické oddělení I. Interní kliniky Thomayerovy nemocnice, Praha 2
Published in: Geriatrie a Gerontologie 2013, 2, č. 1: 40-42
Category: Review Article

Overview

The incidence of depressive disorders in elderly patients is quite common. Selective serotonine reuptake inhibitors (citalopram) are drugs with the lowest occurrence of adverse effects and they are suitable for use in geriatric medicine. Their advantages include, besides antidepressant effects, antiaggregatory effects and other so-called pleiotropic effects.

Keywords:
SSRI – citalopram – geriatric patient – antiaggregatory effects


Sources

1. Hyttel J: The pharmacology of citalopram. Rev Contemp Pharmacother 1995; 6: 271–285.

2. Baumann P, Larsen F: The pharmacokinetics of citalopram. Rev Contemp Pharmacother 1995; 6: 287–295.

3. Kragh-Sorensen P, Overo KF, Petersen OL et al: The kinetics of citalopram: single and multiple dose studies in man. Acta Pharmacol Toxicol 1981; 48: 53–60.

4. Fredericson OK, Toft B, Christophersen L, Gylding-Sabroe JP: Kinetics of citalopram in elderly patients. Psychopharmacol 1985; 86: 253–257.

5. Serebruany VL, O’Connor CM, Krishnan RR: Hypothesis: antiplatelet effects of selective serotonin reuptake inhibitors cause clinical benefits on cardiovascular disease and increase risks of bleeding. J Cardiovasc Pharmacol Ther 2005; 10: 163–164.

6. Skop BP, Brown TM: Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors. Psychosomatics 1996; 37: 12–16.

7. Berger M, Gray JA, Roth BL: The expanded biology of serotonin. Annu Rev Med 2009; 60: 355–366.

8. Galan AM, Lopez-Vilchez I, Diaz-Ricart M et al: Serotonergic mechanisms enhance platelet-mediated thrombogenicity. Thromb Haemost 2009; 102: 511–519.

9. Whyte EM, Pollock BG, Wagner WR et al: Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression. Am J Psychiatry 2001; 158: 2074–2076.

10. Wagner A, Montero D, Martensson B: Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder. J Affect Dis 1990; 20: 101–113.

11. Hergovich N, Aigner M, Eichler HG et al: Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther 2000; 68: 435–442.

12. Javors MA, Houston JP, Tekell JL et al: Reduction of platelet serotonin content in depressed patients treated with either paroxetine or desipramine. Int J Neuropsychopharmacol 2000; 3: 229–235.

13. Balhara Y, Sagar R, Varghese ST: Bleeding gums: duloxetine may be the cause. J Postgrad Med 2007; 53: 44–45.

14. de Abajo FJ, Montero D, Rodríguez LA, Madurga M: Antidepressants and risk of upper gastrointestinal bleeding. Pharmacol Toxicol 2006; 98: 304–310.

15. Maurer-Spurej E: Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection. Cell Mol Life Sci 2005; 62: 159–170.

16. Markovitz JH, Shuster JL, Chitwood WS et al: Platelet activation in depression and effects of sertraline treatment: an open-label study. Am J Psychiatry 2000; 157: 1006–1008.

17. Musselman DL, Marzec UM, Manatunga A et al: Platelet reactivity in depressed patients treated with paroxetine: preliminary findings. Arch Gen Psychiatry 2000; 57: 875–882.

18. Shimbo D, Child J, Davidson K et al: Exaggerated serotonin-mediated platelet reactivity as a possible link in depression and acute coronary syndromes. Am J Cardiol 2002; 89: 331–333.

19. Balhara Y, Sagar R, Varghese ST: Bleeding gums: duloxetine may be the cause. J Postgrad Med 2007; 53: 44–5De Abajo FJ, Montero D, García Rodríguez LA, et al. Antidepressants and risk of upper gastrointestinal bleeding. Pharmacol Toxicol 2006; 98: 304–310.

20. Tiihonen J, Lonnqvist J, Wahlbeck K: Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Arch Gen Psychiatry 2006; 63: 1358–1367.

21. MacDonald TM, McMahon AD, Reid IC et al: Antide-pressant drug use in primary care: a record linkage study in Tayside, Scotland. BMJ 1996; 313: 860–861.

22. Cohen HW, Gibson G, Alderman MH: Excess risk of myocardial infarction in patients treated with antide-pressant medications: association with use of tricyclic agents. Am J Med 2000; 108: 2–8.

23. Sauer WH, Berlin JA, Kimmel SE: Selective serotonin reuptake inhibitors and myocardial infarction. Circulation 2001; 104: 1894–1898.

24. Meier CR, Schlienger RG, Jick H: Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction. Br J Clin Pharmacol 2001; 52: 179–184.

25. Hippisley-Cox J, Pringle M, Hammersley V et al: Antide-pressants as risk factor for ischaemic heart disease: case-control study in primary care. BMJ 2001; 323: 666–669.

26. Sauer WH, Berlin JA, Kimmel SE: Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction. Circulation 2003; 108: 32–36.

27. Rudisch B, Nemeroff CB: Epidemiology of comorbid coronary artery disease and depression. Biol Psychiatry 2003; 54: 227–240.

28. Barth J, Schumacher M, Herrmann-Lingen C: Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 2004; 66: 802–813.

29. Van Melle JP, De Jonge P, Spijkerman TA et al: Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med 2004; 66: 814–822.

30. Van Melle JP, De Jonge P, Honig A et al: Effects of anti-depressant treatment following myocardial infarction. Br J Psychiatry 2007; 190: 460–466.

31. Lesperance F, Frasure-Smith N, Koszycki D et al: Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA 2007; 297: 367–379.

32. Chen Y, Guo JJ, Li H: Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study. Ann Pharmacother 2008; 42: 177–184.

33. Trifiro G, Dieleman J, Sen EF et al: Risk of ischemic stroke associated with antidepressant drug use in elderly persons. J Clin Psychopharmacol 2010; 30: 252–258.

34. Swenson JR, Doucette S, Fergusson D: Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials. Can J Psychiatry 2006; 51: 923–929.

35. De Abajo FJ, Jick H, Derby L et al: Intracranial haemorrhage and use of selective serotonin reuptake inhibitors. Br J Clin Pharmacol 2000; 50: 43–47.

36. Van Walraven C, Mamdami MM, Wells PS, Williams J: Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study. BMJ 2001; 323: 1–6.

37. Dall M, Schaffalitzky De Muckadell OB, Lassen AT, Hallas J: There is an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers: a population-based case-control study. Aliment Pharmacol Ther 2010; 32: 1383–1391.

38. Hernández-Díaz S, Rodríguez LA: Incidence of serious upper gastrointestinal bleeding/perforation in the general population: review of epidemiologic studies. J Clin Epidemiol 2002; 55: 157–163.

39. De Abajo FJ, García-Rodríguez LA: Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents. Arch Gen Psychiatry 2008; 65: 795–803.

40. Barbui C, Andretta M, De Vitis G et al: Antidepressant drug prescription and risk of abnormal bleeding: a case-control study. J Clin Psychopharmacol 2009; 29: 33–38.

41. Targownik LE, Bolton JM, Metge CJ et al: Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding. Am J Gastroenterol 2009; 104: 1475–1482.

42. Dall M, Schaffalitzky de Muckadell OB, Lassen AT et al: An association between selective serotonin reuptake inhibitor use and serious upper gastrointestinal bleeding. Clin Gastroenterol Hepatol 2009; 7: 1314–1321.

43. Verdel BM, Souverein PC, Meenks SD et al: Use of serotonergic drugs and the risk of bleeding. Clin Pharmacol Ther 2011; 89: 89–96.

44. Tanaka A, Takahira Y, Izumi N: Aggravation by selective serotonin re-uptake inhibitors (SSRIs) of antral lesions induced by indomethacin in rats: effects of anti-secretory and mucosal protective drugs [abstract]. Gastroenterology 2005: M2063.

45. Yamaguchi T, Hidaka N, Suemaru K: The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats. Biol Pharm Bull 2008; 31: 1371–1375.

46. Yamamoto T, Abe K, Hattori K et al: High prevalence of gastroduodenal mucosa injury in patients taking selective serotonin reuptake inhibitors [letter]. Digestive Endoscopy 2010; 22: 77.

47. Dall M, Schaffalitzky de Muckadell OB, Lassen AT, Hallas J: There is an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers: a population-based case-control study. Aliment Pharmacol Ther 2010; 32: 1383–1391.

48. Kim DH, Daskalakis C, Whellan DJ: Safety of selective serotonin reuptake inhibitor in adults undergoing coronary artery bypass grafting. Am J Cardiol 2009; 103: 1391–1395.

49. Gärtner R, Cronin-Fenton D, Hundborg HH et al: Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish population-based cohort study. BMC Surg 2010; 10: 3 doi: 10.1186/1471-2482-10-3.

50. Ware JA, Coller BS: Platelet morphology, biochemistry, and function. In: Beutler E, Lichtman MA, Coller BS, et al., editors. William’s hematology. 5th ed. New York: McGraw-Hill, 1995: 1161–1193.

51. Andreasen JJ, Riis A, Hjortdal VE et al: Effect of selective serotonin reuptake inhibitors on requirements for allogeneic red blood transfusion following coronary artery bypass surgery. Am J Cardiovasc Drugs 2006; 6: 243–250.

52. Xiong GL, Jiang W, Clare RM et al: Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting. Clin Cardiol 2010; 33 (6): E94–8 doi: 10.1002/clc.20621.

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Geriatrics General practitioner for adults Orthopaedic prosthetics
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