Vaccination against Covid-19 - IgG antibodies, CIC and complement components in serum
Authors:
K. Absolonová; M. Hill; I. Šterzl
Authors‘ workplace:
Vedoucí laboratorního komplementu: Mgr. Josef Včelák
; Endokrinologický ústav, Praha
Published in:
Prakt. Lék. 2024; 104(3): 112-115
Category:
Of different specialties
Overview
In a group of vaccinated and unvaccinated individuals who did or did not experience Covid-19 disease, we monitored the relationship between anti-SARS-CoV-2 IgG and some parameters that, according to the literature, are important in the development and course of illness of Covid-19. These were total IgG, IgG1-4 subclasses, complement components C3c, C4 and circulating immune complexes (CIC). We found that unvaccinated, vaccinated with Pfizer/BioNTech and Moderna vaccine, as well as advanced and non-advanced Covid-19 patients differed significantly in the level of anti-SARS-CoV-2 IgG. Vaccination had a greater effect on the level of antibodies than experiencing the disease. IgG4 increased in vaccinees after the Pfizer/BioNTech vaccine. Other IgG subclasses, total IgG, CIC and complement components were not statistically significantly different between groups.
Keywords:
vaccination – COVID-19 – IgG – complement components – circulating immune complexes
Sources
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adresa pro korespondenci:
Mgr. Karolína Absolonová, PhD.
Endokrinologický ústav
Národní 8, 110 00 Praha 1
e-mail: kabsolonova@endo.cz
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2024 Issue 3
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