#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hepatitidis E virus


Authors: M. Kubánková 1;  V. Němeček 2;  P. Chalupa 3;  M. Mihalčin 4;  P. Vašíčková 1
Authors‘ workplace: Výzkumný ústav veterinárního lékařství, v. v. i., Brno 1;  Státní zdravotní ústav, Národní referenční laboratoř pro virové hepatitidy, Praha 2;  Klinika infekčních nemocí, 1. lékařská fakulta, Univerzita Karlova v Praze a Ústřední vojenská nemocnice – Vojenská fakultní nemocnice Praha 3;  Klinika infekčních chorob, Fakultní nemocnice Brno, Lékařská fakulta Masarykovy univerzity, Brno 4
Published in: Epidemiol. Mikrobiol. Imunol. 65, 2016, č. 1, s. 4-14
Category: Review Article

Overview

The number of detected cases of hepatitis E (HE) shows an increasing trend in the Czech Republic, probably due the introduction of new diagnostic methods and greater awareness of HE. In most cases, the source of infection has remained unconfirmed or entirely unclear. The causative agent, the hepatitis E virus (HEV), belongs to the Hepeviridae family. Recently, many isolates from mammals, birds, and fish have been identified. HEV is widespread among farm pigs and wild boar populations all over the word. Both species serve as HEV reservoirs. Consumption of undercooked meat or offal from the reservoir animals is considered to be unsafe due to zoonotic transmission of HEV. The aim of the present article is to summarize recent findings regarding HEV.

Key words:
hepatitis E – zoonosis – food-borne infection


Sources

1. Arends JE, Ghisetti V, Irving W, et al. Hepatitis E: An emerging infection in high income countries. J Clin Virol, 2014;59(2):81–88.

2. Van der Poel WHM. Food and environmental routes of Hepatitis E virus transmission. Current Opinion in Virology, 2014;4:91–96.

3. Trmal J, Benes C, Trnkova M. Differences in the incidence of viral hepatitis A and E in the Czech Republic. Epidemiol Mikrobiol Imunol, 2013;62(1):19–25.

4. Chalupa P, Vasickova P, Pavlik I, et al. Endemic Hepatitis E in the Czech Republic. Clin Infect Dis, 2014;58(4):509–516.

5. SZÚ. Vybrané infekční nemoci v ČR v letech 2005–2014 – absolutně. Dostupný na www: http://www.szu.cz/publikace/data/vybrane-infekcni-nemoci-v-cr-v-letech-2003-2012-absolutne.

6. Miyashita K, Kang JH, Saga A, et al. Three cases of acute or fulminant hepatitis E caused by ingestion of pork meat and entrails in Hokkaido, Japan: Zoonotic food-borne transmission of hepatitis E virus and public health concerns. Hepatol Res, 2012;42(9):870–878.

7. Pazderkova J, Sajbertova J, Dlouhy P, et al. Rodinný výskyt hepatitidy typu E v důsledku primární alimentární infekce. Prakti Lék, 2009;89(5):265–267.

8. Trmal J, Pavlik I, Vasickova P, et al. Outbreaks of viral hepatitis E in the Czech Republic? Epidemiol Mikrobiol Imunol, 2012;61(1–2):15–20.

9. Scobie L, Dalton HR. Hepatitis E: source and route of infection, clinical manifestations and new developments. J Viral Hepat, 2013;20(1):1–11.

10. Johne R, Dremsek P, Reetz J, et al. Hepeviridae: An expanding family of vertebrate viruses. Infect, Genet Evol, 2014;27:212–229.

11. Meng XJ. Zoonotic and foodborne transmission of hepatitis E virus. Seminar Liver Dis, 2013;33(1):41–49.

12. Smith DB, Purdy MA, Simmonds P. Genetic variability and the classification of hepatitis E virus. J Virol, 2013;87(8):4161–4169.

13. Smith DB, Simmonds P, Jameel S, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol, 2014;95(Pt 10):2223–2232.

14. Tam AW, Smith MM, Guerra ME, et al. Hepatitis E virus (HEV): Molecular cloning and sequencing of the full-length viral genome. Virology, 1991;185(1):120–131.

15. Takahashi K, Toyota J, Karino Y, et al. Estimation of the mutation rate of hepatitis E virus based on a set of closely related 7.5-year-apart isolates from Sapporo, Japan. Hepatol Res, 2004;29(4):212–215.

16. Guo H, Zhou E-M, Sun ZF, et al. Identification of B-cell epitopes in the capsid protein of avian hepatitis E virus (avian HEV) that are common to human and swine HEVs or unique to avian HEV. J Gen Virol, 2006;87(1):217–223.

17. Perez-Gracia MT, Suay B, Mateos-Lindemann ML. Hepatitis E: An emerging disease. Infec Genet and Evol, 2014;22:40–59.

18. Teo CG. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol Infect, 2012;140(5):767–787.

19. Khuroo MS. Discovery of hepatitis E: The epidemic non-A, non-B hepatitis 30 years down the memory lane. Virus Res, 2011;161(1):3–14.

20. Balayan MS, Andjaparidze AG, Savinskaya SS, et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology, 1983;20(1):23–31.

21. Reyes G, Purdy M, Kim J, et al. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science, 1990;247(4948):1335–1339.

22. Control CfD and Prevention. Investigation of hepatitis E outbreak among refugees-Upper Nile, South Sudan, 2012-2013. MMWR. Morbidity and mortality weekly report, 2013;62(29):581.

23. Lu L, Li C, Hagedorn CH. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol, 2006;16(1):5–36.

24. Smith DB, Simmonds P, Jameel S, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol, 2014.

25. Pischke S, Behrendt P, Bock C-T, et al. Hepatitis E in Germany – an under-reported infectious disease. Dtsch Arztebl International, 2014;111(35-36):577–583.

26. Aggarwal R, Naik S. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol, 2009;24(9):1484–1493.

27. Buti M, Clemente-Casares P, Jardi R, et al. Sporadic cases of acute autochthonous hepatitis E in Spain. J Hepatol, 2004;41(1):126–131.

28. Sehgal R, Patra S, David P, et al. Impaired monocyte-macrophage functions and defective tool-like receptor signalling in hepatitis E virus infected pregnant women with acute liver failure. Hepatology, 2015; 62(6):1683–1696.

29. Teshale EH, Grytdal SP, Howard C, et al. Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in Northern Uganda. Clin Infect Dis, 2010;50(7):1006–1010.

30. Tesse S, Lioure B, Fornecker L, et al. Circulation of genotype 4 hepatitis E virus in Europe: first autochthonous hepatitis E infection in France. J Clin Virol, 2012;54(2):197–200.

31. Wichmann O, Schimanski S, Koch J, et al. Phylogenetic and case-control study on hepatitis E virus infection in Germany. J Infect Dis, 2008;198(12):1732–1741.

32. Garbuglia AR, Scognamiglio P, Petrosillo N, et al. Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emer Infect Dis, 2013;19(1):110.

33. Midgley S, Vestergaard HT, Dalgaard C, et al. Hepatitis E virus genotype 4, Denmark, 2012. Emer Infect Dis, 2014;20(1):156–157.

34. Matsuda H, Okada K, Takahashi K, et al. Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar. J Infect Dis, 2003;188(6):944.

35. Tei S, Kitajima N, Takahashi K, et al. Zoonotic transmis­sion of hepatitis E virus from deer to human beings. The Lancet, 2003;362(9381):371–373.

36. Yazaki Y, Mizuo H, Takahashi M, et al. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J Gen Virol, 2003;84(9):2351–2357.

37. Colson P, Borentain P, Queyriaux B, et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis, 2010;202(6):825–834.

38. Pavio N, Meng XJ, Renou C. Zoonotic hepatitis E: animal reservoirs and emerging risks. Vet Res, 2010;41(6):46.

39. Meng X-J, Purcell RH, Halbur PG, et al. A novel virus in swine is closely related to the human hepatitis E virus. PNatlAcad Sci USA, 1997;94(18):9860–9865.

40. Meng XJ. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet Microbiol, 2010;140(3-4):256–265.

41. van der Poel WHM, Verschoor F, van der Heide R, et al. Hepatitis E virus sequences in swine related to sequences in humans, the Netherlands. Emer Infect Dis, 2001;7(6):970–976.

42. Wenzel JJ, Preiss J, Schemmerer M, et al. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J Clin Virol, 2011;52(1):50–54.

43. Meng XJ. From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety. Virus Res, 2011;161(1):23–30.

44. Arankalle VA, Chobe LP, Joshi MV, et al. Human and swine hepatitis E viruses from Western India belong to different genotypes. J Hepatol, 2002;36(3):417–425.

45. Saad MD, Hussein HA, Bashandy MM, et al. Hepatitis E virus infection in work horses in Egypt. Infect Genet Evol, 2007;7(3):368–373.

46. Caron M, Enouf V, Than S, et al. Identification of genotype 1 hepatitis E virus in samples from swine in Cambodia. J Clin Microbiol, 2006;44(9):3440–3442.

47. Forgach P, Nowotny N, Erdelyi K, et al. Detection of hepatitis E virus in samples of animal origin collected in Hungary. Vet Microbiol, 2010;143(2-4):106–116.

48. Reuter G, Fodor D, Forgách P, et al. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J Clin Virol, 2009;44(4):277–281.

49. Lin J, Norder H, Uhlhorn H, et al. Novel hepatitis E like virus found in Swedish moose. J Gen Virol, 2014;95:557–570.

50. Vasickova P, Kralik P, Slana I, et al. Optimisation of a triplex real time RT-PCR for detection of hepatitis E virus RNA and validation on biological samples. J Virol Methods, 2012;180(1-2):38–42.

51. Takahashi K, Kitajima N, Abe N, et al. Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer. Virology, 2004;330(2):501–505.

52. Kubankova M, Kralik P, Lamka J, et al. Prevalence of hepatitis E virus in populations of wild animals in comparison with animals bred in game enclosures. Food Environ Virol, 2015; 7(2):159–163.

53. Zhao C, Ma Z, Harrison TJ, et al. A novel genotype of hepatitis E virus prevalent among farmed rabbits in China. J Med Virol, 2009;81(8):1371–1379.

54. Cossaboom CM, Córdoba L, Cao D, et al. Complete genome sequence of hepatitis E virus from rabbits in the United States. J Virol, 2012;86(23):13124–13125.

55. Izopet J, Dubois M, Bertagnoli S, et al. Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France. Emerging Infect Dis, 2012;18(8):1274–1281.

56. Liu P, Bu Q-N, Wang L, et al. Transmission of hepatitis E virus from rabbits to cynomolgus macaques. Emerg Infect Dis, 2013;19(4):559.

57. Raj VS, Smits SL, Pas SD, et al. Novel hepatitis E virus in ferrets, the Netherlands. Emerg Infect Dis, 2012;18(8):1369–1370.

58. Lack JB, Volk K, Van Den Bussche RA. Hepatitis E virus genotype 3 in wild rats, United States. Emerg Infect Dis, 2012;18(8):1268–1273.

59. Haqshenas G, Shivaprasad H, Woolcock P, et al. Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis–splenomegaly syndrome in the United States. J Gen Virol, 2001;82(10):2449–2462.

60. Marek A, Bilic I, Prokofieva I, et al. Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes. Vet Microbiol, 2010;145(1–2):54–61.

61. Payne CJ, Ellis TM, Plant SL, et al. Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus. Vet Microbiol, 1999;68(1–2):119–125.

62. Batts W, Yun S, Hedrick R, et al. A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii). Virus Res, 2011;158(1):116–123.

63. Drexler JF, Seelen A, Corman VM, et al. Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae. J Virol, 2012;86(17):9134–9147.

64. Li T-C, Chijiwa K, Sera N, et al. Hepatitis E virus transmission from wild boar meat. Emerging Infect Dis, 2005;11(12):1958–1960.

65. Renou C, Afonso A-MR, Pavio N. Foodborne transmission of hepatitis E virus from raw pork liver sausage, France. Emerg Infect Dis, 2014;20(11):1945–1947.

66. Leblanc D, Poitras E, Gagne MJ, et al. Hepatitis E virus load in swine organs and tissues at slaughterhouse determined by real-time RT-PCR. Int J Food Microbiol, 2010;139(3):206–209.

67. Banks M, Martelli F, Grierson S, et al. Hepatitis E virus in retail pig livers. Vet Rec, 2010;166(1):29.

68. Bouwknegt M, Lodder-Verschoor F, van der Poel WH, et al. Hepatitis E virus RNA in commercial porcine livers in The Netherlands. J Food Prot, 2007;70(12):2889–2895.

69. Feagins AR, Opriessnig T, Guenette DK, et al. Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J Gen Virol, 2007;88(Pt 3):912–917.

70. Berto A, Grierson S, Hakze-van der Honing R, et al. Hepatitis E virus in pork liver sausage, France. Emerg Infect Dis, 2013;19(2):264–266.

71. Riveiro-Barciela M, Minguez B, Girones R, et al. Phylogenetic demonstration of hepatitis E infection transmitted by pork meat ­ingestion. J Clin Gastroenterol, 2015; 49(2):165–168.

72. Vasickova P, Psikal I, Widen F, et al. Detection and genetic characterisation of Hepatitis E virus in Czech pig production herds. Res Vet Sci, 2009;87(1):143–148.

73. Di Bartolo I, Diez-Valcarce M, Vasickova P, et al. Hepatitis E virus in pork production chain in Czech Republic, Italy, and Spain, 2010. Emerg Infect Dis, 2012;18(8):1282–1289.

74. Lorencova A, Vasickova P, Makovcova J, et al. Presence of Mycobacterium avium subspecies and hepatitis E virus in raw meat products. Journal of Food Protection, 2014;77(2):335–338.

75. Feagins AR, Opriessnig T, Guenette DK, et al. Inactivation of infectious hepatitis E virus present in commercial pig livers sold in local grocery stores in the United States. Int J Food Microbiol, 2008;123(1-2):32–37.

76. Yunoki M, Yamamoto S, Tanaka H, et al. Extent of hepatitis E virus elimination is affected by stabilizers present in plasma products and pore size of nanofilters. Vox Sang, 2008;95(2):94–100.

77. Barnaud E, Rogee S, Garry P, et al. Thermal inactivation of infectious hepatitis E virus in experimentally contaminated food. Appl Environ Microbiol, 2012;78(15):5153–5159.

78. Okamoto H. Culture systems for hepatitis E virus. J Gastroenterol, 2013;48(2):147–158.

79. Bouwknegt M, Rutjes SA, Reusken C, et al. The course of hepatitis E virus infection in pigs after contact-infection and intravenous inoculation. BMC Vet Res, 2009;5.

80. Emerson SU, Arankalle VA, Purcell RH. Thermal stability of hepatitis E virus. J Infect Dis, 2005;192(5):930–933.

81. Schielke A, Filter M, Appel B, et al. Thermal stability of hepatitis E virus assessed by a molecular biological approach. Virol J, 2011;8:487.

82. Hoofnagle JH, Nelson KE, Purcell RH. Hepatitis E. New Engl J Med, 2012;367(13):1237–1244.

83. Mirazo S, Ramos N, Mainardi V, et al. Transmission, diagnosis, and management of hepatitis E: an update. Hepat Med, 2014;6:45.

84. Holub M, Korinkova M, Chalupa P. A case of acute hepatitis E acquired in the Czech Republic. Casopis lekaru ceskych, 2008;148(11):549–551.

85. Kruttgen A, Scheithauer S, Hausler M, et al. First report of an autochthonous hepatitis E virus genotype 3 infection in a 5 month old female child in Germany. J Clin Virol, 2011;50(2):175–176.

86. Takahashi M, Tanaka T, Azuma M, et al. Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system. J Clin Microbiol, 2007;45(11):3671–3679.

87. Khudyakov Y, Kamili S. Serological diagnostics of hepatitis E virus infection. Virus Res, 2011;161(1):84–92.

88. Chadha M, Walimbe A, Arankalle V. Retrospective serological analysis of hepatitis E patients: a long-term follow-up study. J Viral Hepatitis, 1999;6(6):457–461.

89. Mast EE, Alter MJ, Holland PV, et al. Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatology, 1998;27(3):857–861.

90. Herremans M, Bakker J, Duizer E, et al. Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity. Clin Vac Immunol, 2007;14(5):562–568.

91. Zhou H, Jiang C, Li L, et al. Comparison of the reliability of two ELISA kits for detecting IgM antibody against hepatitis E virus. Zhonghua yu fang yi xue za zhi (Chinese journal of preventive medicine), 2008;42(9):667–671.

92. Drobeniuc J, Meng J, Reuter G, et al. Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances. Clin Infect Dis, 2010;51(3):e24–e27.

93. Bendall R, Ellis V, Ijaz S, et al. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol, 2010;82(5):799–805.

94. Schnegg A, Bürgisser P, André C, et al. An analysis of the benefit of using HEV genotype 3 antigens in detecting anti-HEV IgG in a European population. PloS one, 2013;8(5):e62980.

95. Wenzel JJ, Preiss J, Schemmerer M, et al. Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. J Infect Dis, 2013;207(3):497–500.

96. Pas SD, Streefkerk RH, Pronk M, et al. Diagnostic performance of selected commercial HEV IgM and IgG ELISAs for immunocompromised and immunocompetent patients. J Clin Virol, 2013;58(4):629–634.

97. Zhao C, Geng Y, Harrison T, et al. Evaluation of an antigen-capture EIA for the diagnosis of hepatitis E virus infection. J Viral Hepatitis, 2015; 22(11):957–963.

98. National Institute for Biological Standardization and Control. Dostupný na www: http://www.nibsc.org/.

99. Abbas Z, Afzal R. Hepatitis E: when to treat and how to treat. Antivir Ther, 2014;19(2):125–131.

100. Nelson KE, Shih JW, Zhang J, et al. Hepatitis E vaccine to prevent morbidity and mortality during epidemics. In Open Forum Infectious Diseases. 2014. Oxford University Press.

101. Teshale EH, Hu DJ, Holmberg SD. The two faces of hepatitis E virus. Clin Infect Dis, 2010;51(3):328–334.

Labels
Hygiene and epidemiology Medical virology Clinical microbiology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#