Authors: L. Pospíšil 1; J. Čanderle 1; K. Zeman 2; H. Štroblová 3; Z. Medková 4 Authors‘ workplace: Výzkumný ústav veterinárního lékařství, Brno 2 I. interní kardioangiologická klinika LF MU – FN u sv. Anny, Brno3 Fakultní nemocnice, Brno 4 Laboratoře Bio Plus s. r. o., Brno 1 Published in: Epidemiol. Mikrobiol. Imunol. , 2003, č. 4, s. 142-146 Category:
Chlamydia pneumoniae (C. p.) is very frequently cited as an important factor of the origin ofatherosclerosis. To confirm the diagnostic value of the serological examination the followingreactions have been used: microimmunofluorescence reaction (MIF) for estimating of antibodiesagainst major outer membrane proteins C. p. (anti-MOMP) and ELISA for detecting antibodiesagainst the lipopolysacharides of C. p. (anti-LPS), both in IgA and IgG immunoglobulin classes ofthe serum. The ELISA for the detection of the IgG antibodies against chlamydial heat shock protein(cHSP60) has been used.The sera of 155 patients suffering from acute myocardial infarction (AMI) and 69 patients withunstable angina pectoris (UAP) have been examined. The heart disease has been confirmed byanamnesis, electrocardiography and coronarography. As a control group the sera from 112 personswithout sings of a heart disease were examined. The antibodies against the cHSP60 have beendetermined only in the sera 69 patients with UAP and 49 control sera.Statistically higher occurrence of the antibodies anti-MOMP C. p. in the IgA class sera of patientssuffering from UAP has been noted compared with those found in the sera of the control group (χ2= 18.56; p
Key words: atherogenesis – cardiovascular diseases – Chlamydia pneumoniae – HSP60.
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