Diagnostic Assetof Assessment of Autoantibodies in Gluten-sensitive Enteropathy

Overview

The study is focused on the immunopathological mechanisms of development of gluten-sensitiveenteropathy (coeliac disease). It describes environmental factors and the role of autoantibodies andautoaggressive cells in the bowel inflammation. Attention is paid to the autoantibodies used inroutine laboratory diagnosis of coeliac disease. The objective is a summary of rational diagnosticalgorithms used in screening, diagnostics, treatment and dispensary care of patients with coeliacdisease, especially with latent forms associated with other organ-specific immunopathologicaldiseases. Exploration of anti-gliadin and anti-endomysial antibodies in diabetes mellitus type I weresubmitted. Furthermore, indications of these tests in the routine laboratory practice was analyzed.

Key words:
gluten-sensitive enteropathy – coeliac disease – diabetes mellitus – thyreopathy –autoimmune polyglandular syndrome – gluten – gliadin – endomysium – tissue transglutaminase –reticulin – autoantibodies.