#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Primary large cell neuroendocrine carcinoma of the urinary bladder


Authors: Jirka Mačák 1;  Pavel Dundr 2;  Jana Dvořáčková 1,3;  Petr Buzrla 1;  David Němec 4
Authors‘ workplace: Ústav patologie, Lékařská fakulta Ostravské univerzity a Fakultní nemocnice Ostrava, Česká republika 1;  Ústav patologie, 1. lékařská fakulta Karlovy univerzity v Praze a Všeobecná fakultní nemocnice v Praze Česká republika 2;  CGB laboratoř a. s. Ostrava, Česká republika 3;  Urologické oddělení, Fakultní nemocnice Ostrava, Česká republika 4
Published in: Čes.-slov. Patol., 49, 2013, No. 2, p. 80-83
Category: Original Article

Overview

Large cell neuroendocrine carcinoma of the urinary bladder is rare. In the last five years, we have had the opportunity to see this type of cancer in an 88-year-old and in a 66-year-old males. In both cases, transurethral resection of carcinoma of the bladder was carried out. In the first case, urothelial carcinoma was detected and deeper in the bladder wall, large cell neuroendocrine carcinoma structures were found. In the second case, the bladder was only infiltrated with large cell neuroendocrine carcinoma. Both tumors expressed NSE, CD56 and synaptophysin. Other markers, such as those against calcitonin, chromogranin, PP, VIP, serotonin, gastrin, glucagon and somatostatin did not react with the tumor.

In the first case, no tumor dissemination was found; in the second case, clinical methods confirmed dissemination into the liver, left adrenal gland, spleen and paracaval lymph nodes. Given his age, the first patient only received symptomatic therapy. The other patient underwent chemotherapy and his condition is stable. Paraneoplastic manifestations of the tumors were not clinically found.

Histogenetic origin of neuroendocrine tumors is not fully clarified. In some cases, tumor development is thought to be associated with Brunn’s nests, cystitis cystica and urothelial carcinoma stem cells.

Keywords:
primary large cell neuroendocrine carcinoma – urinary bladder – immunohistochemistry


Sources

1. Amin MB. Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Modern Pathol 2009; 22: S96-S118.

2. Chen Y-B, Epstein JI. Primary carcinoid tumors of the urinary bladder and prostatic urethra: a clinicopathologic study of 6 cases. Am J Surg Pathol 2011; 35: 442-446.

3. Lee KH, Ryu SB, Lee MC, Park CS, Juhnag SW, Choi C. Primary large cell neuroendocrine carcinoma of the urinary bladder. Pathol Int 2006; 56: 688-693.

4. Sugihara A, Kajio K, Yoshimoto T, et al. Primary carcinoid tumor of the urinary bladder. Int Urol Nephrol 2002; 33: 53-57.

5. Zozumi M, Nakai M, Matsuda I, et al. Primary carcinoid tumor of the urinary bladder with prominent subnuclear eosinophilic granules. Pathol Res Pract 2012; 208: 109-112.

6. Martignoni G, Eble JN. Carcinoid tumors of the urinary bladder. Immunohistochemical study of 2 cases and review of the literature. Arch Pathol Lab Med 2003; 127: e22-e24.

7. Mascolo M, Atieri V, Mignogna C, Napodano G, deRosa G, Insabato L. Calcitonin-producing well-differentiated neuroendocrine carcinoma (carcinoid tumor) of the urinary bladder: case report. BMC Cancer 2005; 27: 88.

8. Bertaccini A, Marchiori D, Cricca A, et al. Neuroendocrine carcinoma of the urinary bladder: case report and review of the literature. Anticancer Res 2008; 58: 1369-1372.

9. Hailemariam S, Gaspert A, Komminoth P, Tamboli P, Amin M. Primary pure large cell neuroendocrine carcinoma of the urinary bladder. Mod Pathol 1998; 11: 1016-1020.

10. Dundr P, Pešl M, Povýšil C, Vítková I, Dvořáček J. Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features. Pathol Res Pract 2003; 199: 559-563.

11. Alijo Serrano F, Sánchez-Mora N, Angel AJ, Hernández C, Alvarez-Fernández E. Large cell and small cell neuroendocrine bladder carcinoma: immunohistochemical and outcome study in a single institution. Am J Clin Pathol 2007; 128: 733-739.

12. Evans AJ, Al-Maghrabi J, Tsihlias J, Lajole G, Sweet JM, Chapman WB. Primary large cell neuroendocrine carcinoma of the urinary bladder. Arch Pathol Lab Med 2002; 126: 1229-1232.

13. Abbas F, Civantos F, Benedetto P, Soloway MS. Small cell carcinoma of the bladder and prostate. Urology 1995; 46: 617-630.

14. Tsugu A, Yoshiyama M, Matsumae M. Brain metastasis from large cell neuroendocrine carcinoma of the urinary bladder. Surg Neurol Int 2011; 2: 84.

15. Lee WJ, Kim CH, Chang SE, et al. Cutaneous metastasis from large-cell neuroendocrine carcinoma of the urinary bladder expressing CK20 and TTF-1. Am J Dermatopathol 2009; 31: 166-169.

16. Buchumensky V, Klein A, Zemer R, Kessler OJ, Zimlichman S, Nissenkom J. Cytokeratin 20: a new marker for early detection of bladder carcinoma? J Urol 1998; 160: 1971-1974.

17. Martin IJP, Vilar DG, Aguado JM, et al. Large cell neuroendocrine carcinoma of the urinary bladder. Bibliographic review. Arch Esp Urol 2011; 64: 105-113.

18. Li Y, Outman JE, Mathur SC. Carcinosarcoma with a large cell neuroendocrine epithelial component: first report of an unusual biphasic tumour of the urinary bladder. J Clin Pathol 2004; 57: 318-320.

19. Cheng L, Pan CX, Yang XJ, et al. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer 2004; 101: 957-962.

20. Choong NW, Quevedo JF, Kaur JS. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer 2005; 103: 1172-1178.

21. Church DN, Bahl A. Clinical review – small cell carcinoma of the bladder. Cancer Treat Rev 2006; 32: 588-593.

22. Ismaili N, Heudel PE, Elkarak F, et al. Outcome of recurrent and metastatic small cell carcinoma of the bladder. BMC Urol 2009; 9: 1-8.

23. Pan CX, Yang XJ, Lopez-Beltran A, et al. c-kit expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. Mod Pathol 2005; 18: 320-323.

24. Bex A, Nieuwenhuijzen JA, Kerst M, et al. Small cell carcinoma of bladder: a single-center prospective study of 25 cases treated in analogy to small lung cancer. Urology 2005; 65: 295-299.

25. Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS. Small cell carcinoma of the bladder. BJU Int 2004; 94: 12-17.

26. Abrahams NA, Moran C, Reyes AO, Siefker-Radtke A, Ayala AG. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology 2005; 46: 57-63.

Labels
Anatomical pathology Forensic medical examiner Toxicology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#