Authors: M. Zámečník 1; A. Skřivánek 2 Authors‘ workplace: Šikl’s Department of Pathology, Medical Faculty Hospital Charles University, Pilsen, Czech Republic 1; Private Gynecologic Surgery, Olomouc, Czech Republic 2 Published in: Čes.-slov. Patol., 41, 2005, No. 4, p. 157-162 Category: Original Article
A case of adenoid basal epithelioma (ABE) of the uterine cervix in 21-year-old woman is reported. The patient’s age appears to be lowest among cases of ABE reported to date. The tumor showed typical histologic features of ABE and was associated with CIN3. In addition, rare tumor cells had surface cilia-appearing structures suggesting tubal differentiation. Immunohistochemically, the tumor was reactive for p63, CD10, ER, PR, p16 and bcl-2, and negative for CEA. Thus, the immunophenotype also suggests possible partial tuboendometrioid differentiation in the glandular component of the lesion. It further indicates, along with finding of associated CIN, a role of oncogenic HPV in pathogenesis of ABE.
Key words: adenoid basal epithelioma – CIN – CD10 – tuboendometrioid differentiation – uterine cervix
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