Diagnosticand Prognostic Role of Proliferation Marker MIB-1 inThyroid Tumors


Authors: M. Ludvíková;  A. Ryška;  E. Hovorková;  R. Pikner
Published in: Čes.-slov. Patol., , 2002, No. 1, p. 4-10
Category:

Overview

Well-differentiated thyroid tumors may sometimes cause diagnostic uncertainty due to difficultiesin the evaluation of certain morphological criteria (capsular and/or vascular invasion, cytomorphological features). Therefore, various diagnostic/prognostic markers are currently studied, namely the markers of tumor proliferation.The aim of our study was to evaluate the proliferative MIB-1 index in 155 thyroid tumors, and tocorrelate it with morphological diagnosis, size of the tumors, and the patients’ age. Oncocytictumors were represented by 59 follicular adenomas, 27 follicular carcinomas and 12 papillocarcinomas. Nononcocytic tumors comprised 24 follicular adenomas and 33 conventional papillarycarcinomas. The Ki-67 antigen (formalin resistant epitope MIB-1) was detected immunohistochemically and the proliferative index (PI) of tumors was evaluated. The results were statisticallyanalyzed using analysis of variance (ANOVA) and Wilcoxon tests (significance level p

Key words:
thyroid gland - tumor - oncocytes - MIB-1 - proliferation

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Labels
Anatomical pathology Forensic medical examiner Toxicology
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