Evaluation of Trace Analyses Methods of Various Opiates IncludingHydrocodone and Hydromorphone in Blood or Urine by GC-MS

Czech version

Authors: M. Balíková; V. Marešová; V. Habrdová
Authors‘ workplace: Ústav pro toxikologii a soudní chemii, 1. LF UK a VFN, Praha, vedením Ústavu pověřena Ing. Nováková Eva, CSc.
Published in: Čes.-slov. Patol., , 2000, No. 1, p. 11-16
Category:

Overview

A GC-MS method suitable to conduct practical trace toxicological analyses of various opiatesincluding hydrocodone or hydromorphone is presented both in scan and selected ion monitoringmodes. Silylation can be a convenient reaction to derivatize unknown analytes in toxicologicalsamples. However, silylation of drugs with tautomeric keto/enol groups in molecular structurecan cause analytical problems due to poor reproducibility of conversion degree. After usingN-Methyl-N-trimethyl-silyltrifluoracetamide (MSTFA) acceptable results were achieved.

Key words:
GC-MS toxicological analyses, silylderivatives, hydrocodone, hydromorphone

Full text is not available online.

If interested in a scan of this journal, contact NTO ČLS JEP.

Labels

Anatomical pathology Forensic medical examiner Toxicology

The Method of DNA Isolation Can Affect the Rate of PreferentialAmplification of Alleles by the Polymerase Chain Reaction

Paraffin-Embedded Tissues as a Source of the Control DNA

Forensic and Criminological View on the Pathodynamics of the Homicide

Peripheral T and NK Cell Tumors

Surgical Pathology of the Heart Valves. A Study of 872 Cases

Fetal Rhabdomyoma of the Lower Lip (Case Report)

Tumor angiogenesis. Part I. Its Role in Determination of Tumor Behavior;Factors Regulating Angiogenesis

Proliferative Activity in Pulmonary Carcinoids

Article was published in

Czecho-Slovak Pathology

2000 Issue 1