The Sensitive GC-MS Evidence of Benzodiazepines in urine asTrimethylsilylderivatives

Czech version

Authors: M. Balíková; V. Marešová; J. Večerková
Authors‘ workplace: Ústav pro toxikologii a soudní chemii, 1. LF UK a VFN, Praha, vedením ústavu pověřena Ing. E. Nováková, CSc.
Published in: Čes.-slov. Patol., , 1999, No. 3, p. 34-42
Category:

Overview

A sensitive evidence of trace concentrations of benzodiazepines and their metabolites in urinecan be enabled after special sample preparation including enzymatic hydrolysis, special solidphase extraction, silylation and folowing analysis by gas chromatograhpy with mass spectrometryin electron impact mode. After optimalization of the procedure the extraction recovery values inthe range 50 -⁠ 85 % are achieved. The scale of retention times with basic mass spectral data arepresented for the spectrum of silylated benzodiazepines which can overlap some gaps in thestandard toxicological literature up to now available.

Key words:
Benzodiazepine derivates -⁠ biotransformation -⁠ metabolites, toxicological evidence -GC-MS trace analysis in urine

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Article was published in

Czecho-Slovak Pathology

1999 Issue 3