#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

EFFECTS OF FREE RADICALS ON MALE FERTILITY AND AVAILABLE TREATMENT


Authors: Lukáš Bittner 1,4;  Matúš Chocholatý 2;  Marcela Čechová 2;  Tomáš Zima 3;  Robert Grill 1
Authors‘ workplace: Urologická klinika 3. LF UK a FNKV, Praha 1;  Urologická klinika 2. LF UK a FN Motol, Praha 2;  Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha 3;  Iscare IVF, Praha 4
Published in: Ces Urol 2015; 19(1): 11-18
Category: Review article

Overview

In half of the cases of infertility in infertile pairs is due to the pathology of the man. Oxidative stress is one of the reasons of impaired fertility in a male. This article analyses the etiology and mechanism of oxidative stress and summarizes the current state of knowledge regarding the diagnostics options and treatment of oxidative stress of sperm.

KEY WORDS:
Antioxidants, free radicals, male infertility, sperm, oxidative stress.


Sources

1. Snick H, Snick T, Evers J, Collins J. The spontaneous pregnancy prognosis in untreated subfertile couples: the Walcheren primary care study. Human Reproduction 1997; 12(7): 1582–1588.

2. Greenhall E, Vessey M. The prevalence of subfertility – a review of the current confusion and a report of 2 new studies. Fertility and Sterility 1990; 54(6): 978–983.

3. Tielemans E, Burdorf A, te Velde E, et al. Sources of bias in studies among infertility clients. American Journal of Epidemiology 2002; 156(1): 86–92.

4. MacLeod J. The role of oxygen in the metabolism and motility of human spermatozoa. Am J Physiol 1943; 138(3): 512–518.

5. Jones R, Mann T, Sherins R. Peroxidative breakdown of phospholipids in human-spermatozoa, spermicidal properties of fatty-acid peroxides, and protective action of seminal plasma. Fertility and Sterility 1979; 31(5): 531–537.

6. Tremellen K. Oxidative stress and male infertility – a clinical perspective. Human Reproduction Update 2008; 14(3): 243–258.

7. Baker M, Aitken R. Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Reproductive Biology and Endocrinology 2005; 3.

8. Twigg J, Fulton N, Gomez E, Irvine D, Aitken R. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Human Reproduction 1998; 13 (6): 1429–1436.

9. Sanocka D. Reactive oxygen species and sperm cells. Reproductive Biology & Endocrinology 2004; 12–17.

10. Aitken R, Buckingham D, Brindle J, et al. Analysis of sperm movement in relation to the oxidative stress created by leukocytes in washed sperm preparations and seminal plasma. Human Reproduction 1995; 10(8): 2061–2071.

11. Alvarez J, Storey B. Differential incorporation of fatty-acids into and peroxidative loss of fatty-acids from phospholipids of human spermatozoa. Molecular Reproduction and Development 1995; 42(3): 334–346.

12. Twigg J, Irvine D, Aitken R. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Human Reproduction 1998; 13(7): 1864–1871.

13. Thomas N, Durkie M, Van Zyl B, et al. Parental and chromosomal origin of unbalanced de novo structural chromosome abnormalities in man. Human Genetics 2006; 119(4): 444–450.

14. Agarwal A, Saleh R, Bedaiwy M. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertility and Sterility 2003; 79(4): 829–843.

15. Akbay E, Cayan S, Doruk, E, Duce M, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. Bju International 2000; 86(4): 490–493.

16. Canales B, Zapzalka D, Ercole C, et al. Prevalence and effect of varicoceles in an elderly population. Urology 2005; 66(3): 627–631.

17. Raman J, Walmsley K, Goldstein M. Inheritance of varicoceles. Urology 2005; 65(6): 1186–1189.

18. Agarwal A. Relationship between oxidative stress, varicocele and infertility: a meta-analysis. Reproductive

Biomedicine Online 2006; 12(5): 630–633.

19. Zini A, Blumenfeld A, Libman J, Willis J. Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity. Human Reproduction 2005; 20(4): 1018–1021.

20. Werthman P, Wixon R, Kasperson K, Evenson D. Significant decrease in sperm deoxyribonucleic acid fragmentation after varicocelectomy. Fertility and Sterility 2008; 90(5): 1800–1804.

21. Marmar J, Agarwal A, Prabakaran S, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertility and Sterility 2007; 88(3): 639–648.

22. Wayner D, Burton G, Ingold, K. The antioxidant efficiency of vitamin-C is concetration-dependent. Biochimica Et Biophysica Acta 1986; 884(1): 119–123.

23. Jacob R, Pianalto F, Agee R. Cellular ascorbate depletion in healthy-men. Journal of Nutrition 1992; 122(5): 1111–1118.

24. Lewis S, Sterling E, Young, I, Thompson W. Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men. Fertility and Sterility 1997; 67(1): 142–147.

25. Dawson E, Harris W, Teter M, Powell L. Effect of ascorbic-acid supplementation on the sperm quality of smokers. Fertility and Sterility 1992; 58(5): 1034–1039.

26. Geva E, Lessing J, Bartoov B, et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertility and Sterility 1996; 66(3): 430–434.

27. Alleva R, Scararmucci A, Mantero F. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Molecular Aspects of Medicine 1997; 18: 221–228.

28. Mancini A, Demarinis L, Oradei A, et al. Coenzyme Q-10 concentrations in normal and pathological human seminal fluid. Journal of Andrology 1994; 15(6): 591–594.

29. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q 10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertility and Sterility 2004; 81(1): 93–98.

30. Balercia G, Buldreghini E, Vignini A, et al. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertility and Sterility 2009; 91(5): 1785–1792.

31. Bleau G, Lemarbre J, Faucher G, Roberts K, Chapdelaine A. Semen selenium and human-fertility. Fertility and Sterility 1984; 42(6): 890–894.

32. Kvíčala J. Zvýšení příjmu mikronutrientu selenu – utopie, fikce, prozřetelnost či nutnost? – II. část. Interní med. 2003; 7: 354–359.

33. Safarinejad M, Safarinejad S. Efficacy of Selenium and/or N-Acetyl-Cysteine for Improving Semen Parameters in Infertile Men: A Double-Blind, Placebo Controlled, Randomized Study. Journal of Urology 2009; 181(2): 741–751.

34. Omu A, Al-Azemi M, Kehinde E, et al. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Medical Principles and Practice 2008; 17(2): 108–116.

35. Witschi A, Reddy S, Stofer B, Lauterburg B. The systemic availability of oral glutathione. European Journal of Clinical Pharmacology 1992; 43(6): 667–669.

36. Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status. Urology 2009; 74(1): 73–76.

37. Lenzi A, Culasso F, Gandini L, Lombardo, F, Dondero, F. Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male-infertility. Human Reproduction 1993; 8(10): 1657–1662.

38. Ermanno G. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Human Reproduction 2005; 20(9): 2590–2594.

39. Imhof M, Lackner J, Lipovac M, Chedraui P, Riedl C. Improvement of sperm quality after micronutrient supplementation. e-SPEN Journal 2012; 7(1): 50–53.

40. Parekattil SJ, Agarwal A. Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants. Springer 2012: 228.

Labels
Paediatric urologist Nephrology Urology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#