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Leydig cell tumor


Authors: Katarína Lenková;  Jan Vašinka;  Martin Labovský
Authors‘ workplace: Urologické oddělení Nemocnice Znojmo, a. s.
Published in: Ces Urol 2014; 18(1): 61-64
Category: Case report

Overview

We report about a case of a Leydig cell tumor, which is one of the most common nongerminal tumors of the testis. Endocrine symptoms, which develop due to the tumors hormonal activity, can be the only sign of the disease. The overproduction of hormones leads to the hypogonadism and can also lead to infertility. Some Leydig cell tumors are malignant with metastatic potential. The treatment is surgical and prognosis depends on early diagnosis.

Key words:
fertility, hypogonadism, Leydig cells, tumor, testis.


Sources

1. Fadl Tazi M, Mellas S, Jamal El Fassi M. Leydig cell hyperplasia revealed by gynecomastia. Rev Urol 2008; 10(2): 164–167.

2. Holm M, Rajpert-De Meyts E, Andersson A-M, Skakkebk NE. Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio. J Pathol 2003; 199: 378–386.

3. Liu G, Duranteau L, Carel JC, Monroe J, Doyle DA, Shenker A. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N Engl J Med 1999; 341: 173–176.

4. Fragoso MC, Latronico AC, Carvalho FM. Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. J Clin Endocrinol Metab 1998; 83: 2074–2081.

5. Poster RB, Katz DS. Leydig cell tumor of the testis in Klinefelter syndrome: MR detection. Comput Assist Tomogr 1993; 17: 480–481.

6. Carroll PR, Morse MJ, Koduru PP, Chaganti RS. Testicular germ cell tumor in patient with Klinefelter syndrome. Urology 1988; 31: 72–74.

7. Kawaciuk I. Urologie, Praha: Galén 2009.

8. Ponce de Leon Roca J, Algaba Arrea F, Bassas Arnau L, Villavicencio Mavrich H. Leydig cell tumor of the testis. Arch Esp Urol 200; 53: 453–458.

9. Kalfon A, Abram F, Kirsch-Noir F, et al. Les tumeurs testiculaires à cellules de Leydig. A propos de 10 observations. Prog Urol 1999; 9: 299–304 (Fre).

10. Zeev V. Maizlin, Belenky A, Kunichezky M, Sandbank J, Strauss S. Leydig Cell Tumors of the Testis Gray Scale and Color Doppler Sonographic Appearance ChBJ Ultrasound Med 2004; 23: 959–964.

11. Richmond I, Banerjee SS, Eyden BP, et al. Sarcomatoid Leydig cell tumor of the testis. Histopathology 1995; 27: 578–580.

12. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM. Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am J Surg Pathol 1998; 22: 1361–1367.

1 3. McCluggage WG, Shanks JH, Whiteside C, Maxwell P, Banerjee SS, Biggart JD. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol 1998; 22: 615–619.

14. Kratochvíl P. Benigní tumory varlete-záchovné operace, Urolog. pro Praxi 2010; 11(6): 310–312.

15. Hyršl L, Abrahámová J, Zuntová A, Kawaciuk I, Dušek P. Nádory varlete z Leydigových a Sertoliho buněk /Didymal tumours from leydig and sertoli cells. Ces Urol 2005; 9(3): 16–19.

16. Bertram KA, Bratlof B, Hodges GF, Davidson H. Treatment of malignant Leydig cell tumor. Cancer 1991; 68: 2324–2329.

17. Mineur P, De Cooman S, Hustin J, et al. Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. J Clin Endocrinol Metab 1987; 64: 686–691.

Labels
Paediatric urologist Nephrology Urology
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