Association of HLA-DR and -DQ Alleles with Pemphigus Vulgaris in Slovak Population
Authors:
Z. Párnická 1; N. Rakovan 2; D. Švecová 2; M. Buc 1
Authors‘ workplace:
Imunologický ústav LFUK, Bratislava
prednosta prof. MUDr. Milan Buc, DrSc.
1; Dermatovenerologická klinika LFUK, Bratislava
prednostka prof. MUDr. Mária Šimaljaková, PhD.
2
Published in:
Čes-slov Derm, 85, 2010, No. 3, p. 148-152
Category:
Clinical and laboratory Research
Overview
Pemphigus vulgaris (PV) is an autoimmune disease with genetic predisposition associated mostly with HLA complex alleles. We examined whether this holds true for Slovak population similarly to other Caucasian populations. In 32 patients the frequency of HLA-DRB1 and DQB1 alleles was examined and compared to healthy population. The statistically significant positive association with alleles DRB1*14 (20,31 % vs. 2,69 %, OR = 9,2, Pc< 0,001) and DRB1*04 (39,06 % vs. 11,16 %, OR = 5,1, Pc< 0,001) was found. DQB1*03 and DQB1*05 alleles were more frequent but not on a significant level. DQB1*06 were significantly lower in PV patients in comparison with control group (3,12 % vs. 20,61 %; OR = 0,12, Pc = 0,002). Lower, statistically non-significant frequency was noted for DRB1*11 and DRB1*15 alleles. These results correspond well with the literature and help to overall genetic characteristics of the disease.
Key words:
pemphigus vulgaris – HLA complex and diseases – Slovak population
Sources
1. BIROL, A., ANADOLU, RY., TUTKAK, H., GURGEY, E. HLA-class 1 and class 2 antigens in Turkish patients with pemphigus. Int J Dermatol, 2002, 41, p. 79-83.
2. BUC M. Autoimunita a autoimunitné choroby. Bratislava: Veda 2005; 493 s.
3. DUNN, OJ. Multiple comparisons among means. Am J Statist Assoc, 1961, 56, p. 52-64.
4. FAZEKAŠOVÁ, H., SHAWKATOVÁ, I., BUC, M., FERENČÍK, S.: Frekvencia alel lokusov HLA-DRB1 a HLA- DQB1 v slovenskej populácii. Bratisl lek Listy, 1998, 99, 11, p. 601-604.
5. FRIEDMAN A. HLA and Dermatological Disease In LECHLER, R., WARRENS A. HLA in Health and Disease. 2. vyd., Academic Press, London, 2000, p. 365-369. ISBN 0 12 440315 8.
6. GLORIO, RR., RODRIGUEZ COSTA, G., HAAS, R., et al. HLA haplotypes and class II molecular alleles in Argentinian patients with pemphigus vulgaris. J Cutan Med Surg, 2002, 6, 5, p. 422-426.
7. GONZALEL-ESCRIBANO, MF., JIMENEZ, G., WALTER, K., et al. Distribution of HLA class II alleles among Spanish patients with pemphigus vulgaris. Tissue Antigens, 1998, 52, p. 275.
8. KREJSEK, J., KOPECKÝ O. Klinická imunologie. Pardubice: Nucleus, 2004, s. 302. ISBN 80-86225-50-X.
9. LEE, E., LENDAS, KA., CHOW, S., et al. Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Human Immunology, 2007, 68, p. 630-643.
10. LI, N., LIU, Z., HILARIO-VARGAS, J., DIAZ LA. Bullous Skin Diseases: Pemphigus Pemphigoid. In ROSE, NR., MACKAY, IR. The Autoimmune Diseases. Elsevier Academic Press, 4th Ed., 2006, p. 789-794.
11. LOISEAU, P., LECLEACH, L., PROST, C., et al. HLA class II polymorphism contributes to specify desmoglein derived peptides in pemphigus vulgaris and pemphigus foliaceus. J Autoimmun, 2000, 15, p. 67-73.
12. LOMBARDI, ML., MERCURO, O., RUOCCO, V. et al.: Common human leucocyte antigen alleles in pemphigus vulgaris and pemphigus foliaceus Italian patients. J Invest Dermatol, 1999, 113, p. 107-110.
13. Nguyen, VT., Assane Ndoye, A., Grado, SA. Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine. J Biol Chem, 2000, 275, p. 29466-29476.
14. OLERUP, O., ALDNER, A., FODGELL, A. HLA-DQB1 and DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens, 1993, 41, s. 119-134.
15. OLERUP, O., ZETTERQUIST, H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens, 1992, 39, 5, p. 225-235.
16. SÁENZ-CANTELE, AM., FERNÁNDEZ-MESTRE, M., MONTAGNANI, S., et al. HLA-DRB1*0402 haplotypes without DQB1*0302 in Venezuelan patients with pemphigus vulgaris. Tissue antigens, 2007, 69, s. 318-325.
17. ŠVECOVÁ, D. Pemphigus. Bratislava: Bonus, 2009, 106 s.
18. TUR, E., BRENNER, S. Contributing exogenous factors in pemphigus. Int J Dermatol, 1997, 36, p. 888-893.
Labels
Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2010 Issue 3
Most read in this issue
- Phototherapy in the Czech Republic
- Mastocytosis in Children
- Intense Pulsed Light – Biological and Physical Effects
- Lymphogranuloma Venereum: in the Czech Republic Already?