Case Study of Patient with Blastic NK-cell Lymphoma also Termed CD4+/CD56+ Hematodermic Neoplasia or Early Plasmocytoid Leukaemia/ Dendritic Cell Lymphoma

Czech version

Authors: E. Minariková ¹; L. Plank ²; J. Péč ¹
Authors‘ workplace: Dermatovenerologická klinika JLF UK a MFN v Martine prednosta prof. MUDr. Juraj Péč, CSc. ¹; Ústav patologickej anatómie JLF UK a MFN v Martine prednosta prof. MUDr. Lukáš Plank, CSc. ²
Published in: Čes-slov Derm, 83, 2008, No. 4, p. 204-208
Category: Case Reports

Overview

A case of 81-year-old patient with blastic NK-cell lymphoma or CD4+/CD56+ hematodermic neoplasia diagnosed from histological examination of the excised subcutaneous nodule under the right eyebrow is presented. Inspite of chemotherapy, the rapid leukemic dissemination of aggresive type of lymphoma occurred and patient died 10 months after the beginning of treatment. Authors present clinical and histological picture of blastic NK-cell lymphoma and immunohistochemical demonstration of CD4+ and CD56+ cells.

Key words:
blastic NK-cell lymphoma – CD4+/CD56+ hematodermic neoplasia – early plasmocytoid leukaemia/dendritic cell lymphoma – immunohistochemistry

Sources

1. Child, FJ., Mitchell, TJ., Whittaker, SJ. et al. Blastic natural killer cell and extranodal natural killer cell-like T-cell lymphoma presenting in the skin: report of six cases from U.K. Br J Dermatol. 2003,148, p. 507-515.

2. Emiko, A., Tomotaka, M., Yoshinori,U. et al. A case of blastic NK-cell lymphoma. Int J Dermatol. 2007, 46, p. 722-726.

3. Martin, JM., Nicolau, MJ., Galán, A. et al. CD4+/CD56+ hematodermická neoplázia: a precursor haematological neoplasm that frequently first presents in the skin. JEAD. 20, p. 1129-1132.

4. Slater, D. N. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br J Dermatol. 2005, 153, s. 874-880.

5. Sung Eun Chang, Hye-Jin Choi, Jooryung Huh et al. A case of cutaneous blastic NK lymphoma in a 32-year-old Korean women. Int J of Dermatol, 2005, 45, s. 591-593.

6. Willemze, E., Jaffe, S. E., Burg, G et al. WHO-EORTC Classification for cutaneous lymphomas. Blood, 2005, 105 (10), p. 3768-3785.

Labels

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Article was published in

Czech-Slovak Dermatology

2008 Issue 4