Comparative Study of Acne Treatment with Vaccines and Systemic Antibiotics. Part 2: Characteristics of Bacterial Strains Isolated from Acne Lesions and their Antibiotic Resistance
1; D. Koukalová
1; M. Viktorinová
2; P. Sauer
1; J. Síla
Ústav mikrobiologie LF UP a FN Olomouc
přednostka doc. MUDr. D. Koukalová, CSc.
1; Klinika chorob kožních a pohlavních LF UP a FN Olomouc
přednostka doc. MUDr. D. Ditrichová, CSc.
Čes-slov Derm, 82, 2007, No. 2, p. 82-86
Clinical and laboratory Research
Authors characterized skin microflora in 51 patients with acne after treatment either with vaccine or antibiotics. They also verified genetic homology of phenotypically identical isolates repetitively taken from the same patient and determined selected virulence factors in Staphylococcus aureus species. Study confirmed participation of staphylococci and propionibacteriae in etiopathogenesis of acne and documented statistically not significant influence of both treatment modalities on the above mentioned pathogens. Sensitivity tests confirmed only low resistance of Propionibacterium acnes to klindamycin (6.7%) and higher resistance of Staphylococcus epidermidis species (73.4% to erythromycin and 62.2% to klindamycin). Significant resistance changes were not demonstrated during study.
Identical phenotype of coagulase negative staphylococci strains was found in 12 patients. Electrophoretic DNA profile analysis revealed genetic homology in 6 (50%) cases. Virulence factors detection demondetekostrated presence of gene for Panton-Valentine leukocidine synthesis in 3 Staphylococcus aureus strains. No enterotoxin A and TSST-1 genes were found.
acne – Propionibacterium acnes – Staphylococcus sp. – antibiotic resistance – factors of virulence
Dermatology & STDs
Paediatric dermatology & STDs