Long-term outcomes of ixekizumab treatment in patients with axial spondyloarthritis
Authors:
K. Bubová
Authors‘ workplace:
Revmatologický ústav Praha a Revmatologická klinika 1. LF UK, Praha
Published in:
Čes. Revmatol., 31, 2023, No. 3, p. 145-150.
Category:
Úvodník
Overview
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145 |
Axial spondyloarthritis (axSpA) is a systemic inflammatory disease that can significantly contribute to the deterioration of the quality of life. That is why nowadays the emphasis is placed on early diagnosis and initiation of treatment. Ixekizumab is an inhibitor of interleukin (IL)-17A, which has shown good efficacy with long-term efficacy in patients with a radiographic form of the disease (r-axSpA) who were naïve to the use of biological treatment, in patients treated with tumor necrosis factor inhibitors (TNFi), and in non-radiographic (nr-axSpA) patients. In addition, current three-year follow-up data from the COAST studies did not show significant changes in the safety profile compared to previously reported adverse events. In addition, 89.6% of patients with r-axSpA had stable radiographic findings after 2 years, which is similar to the results of other IL-17 inhibitors. However, it should be noted that radiographic progression in axSpA is slow and the minimum time needed to evaluate it is 2 years. Therefore, a multi-year follow-up is needed so that the effect on radiographic progression can be fully demonstrated.
Keywords:
ixekizumab – axial spondyloarthritis – IL-17 inhibitors
Sources
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Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
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