Are risk factors in prenatal and perinatal period important for develompent of schizophrenia?
Authors:
P. Ambroz 1; J. Janoutová 1; O. Machaczka 1; M. Kovalová 1; A. Pohlídalová 1; K. Vařechová 1; O. Košta 1; H. Tomášková 1; O. Šerý 2; L. Hosák 3; V. Janout 1
Authors‘ workplace:
Ústav epidemiologie a ochrany veřejného zdraví LF OU, Ostrava, vedoucí ústavu prof. MUDr. V. Janout, CSc.
1; Ústav živočišné fyziologie a genetiky AV ČR, Laboratoř embryologie živočichů, Brno, vedoucí ústavu
prof. MVDr. J. Míšek, CSc.
2; Psychiatrická klinika FN, Hradec Králové, přednosta kliniky prof. MUDr. L. Hosák, Ph. D.
3
Published in:
Ceska Gynekol 2017; 82(1): 24-27
Overview
Objective:
Schizophrenia is an important psychical disease of multifactorial origin and not yet clear etiology. In prenatal and perinatal period some potential risk factors for schizophrenia are taken into consideration.
Design:
Case-control study of 815 subjects, 407 cases and 408 controls was performed in 2013 to 2015.
Methods:
In this study environmental and genetic risk factors were evaluated including potential risk factors of prenatal and perinatal period.
Results:
Statistically important difference was found in childbirth done by cesarean section (p = 0.009) and in patients with schizophrenia were 15.7% complications in the course of childbirth (p < 0.001). Hypoxia, passed umbilical cord were the most frequent complications. In prenatal period premature childbirth, injury and psychical complications were the most frequent. On the other hand difference in weight and length of newborns, breast feeding and infection during pregnancy were found not statistically important.
Conclusion:
In this study statistically important diference were found in way of carrying childbirth and in some complications during pregnancy and delivery. Influence of infection during pregnancy and influence of weight and length of newborn were not demonstrated.
Keywords:
schizophrenia, risk factors, pregnancy, childbirth, infection
Sources
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine Paediatric psychiatry General practitioner for adults Psychiatry Internal medicine CardiologyArticle was published in
Czech Gynaecology
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