#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Oncofertility – a new trend in reproductive medicine


Authors: M. Huser;  I. Crha;  J. Žáková;  P. Ventruba
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno, přednosta prof. MUDr. P. Ventruba, DrSc.
Published in: Ceska Gynekol 2011; 76(2): 91-99

Overview

Effective treatment of cancer often causes patients irreversible damage of reproductive abilities. New trend in reproductive medicine commonly described as oncofertility offers cancer patients not only infertility treatment, but also potent prevention of irreversible damage of reproductive organs and functions. Efficacious methods of women reproductive function damage prevention has been developed at Brno University Hospital Department of Obstetrics and Gynecology since year 2004. The paper describes current oncofertility techniques implemented to clinical practice – embryo and oocyte banking, ovarian tissue cryopreservation including further possibility of its orthotopic autotransplantation and administration of gonadoliberin analogues for ovarian protection. During past 6 years expert consultation before start of gonadotoxic treatment has been provided to 195 young women with newly diagnosed cancer or autoimmune disease. Attention is applied to pro and contras of previously described methods of ovarian protection in the discussion. Limitations regarding implementation of oncofertility techniques in practice are mentioned. Furthermore short recommendations regarding pre-treatment oncofertility consultation with patients are given.

Key words:
infertility, oncofertility, ovarian tissue cryopreservation, vitrification, oocyte cryopreser­vation.


Sources

1. Huser, M., Crha, I., Zakova, J., Ventruba, P. Proces reprodukčního stárnutí ženy – příčiny, stanovení a možnosti užití v praxi. Čes Gynek, 2010, 75, s. 353-358.

2. Němec, P., Huser, M., Souček, M. Možnosti ochrany reprodukčních funkcí u žen podstupujících léčbu cytotoxickými léky. Vnitřní Lék, 2008, 54, s. 191-196.

3. Crha, I., Ventruba, P., Zakova, J., et al. Survival and infertility treatment in male cancer patients after sperm banking. Fertil Steril, 2009, 91, p. 2344-2348.

4. Woodruff, TK., Snyder, KA. Oncofertility – fertility preser­vation for cancer survivors. Springer, 2007, p. 1-255.

5. Tournaye, H., Clasen, K., Aytoz, A., et al. Fine needle aspiration versus open biopsy for testicular sperm recovery: a controlled study in azoospermic patients with normal spermatogenesis. Hum Reprod, 1998, 13, p. 901-904.

6. Subak, LL., Adamson, GD., Boltz, NL. Therapeutic donor insemination: a prospective randomized trial of fresh versus frozen sperm. Am J Obstet Gyn, 1992, 166, p. 1597-1604; discussion p. 1604-1596.

7. Anger, JT., Gilbert, BR., Goldstein, M. Cryopreservation of sperm: indications, methods and results. J Urol, 2003, 170, p. 1079-1084.

8. Crha, I., Dostal, J., Ventruba, P., et al. [Posthumous sperm procurement and use - ethical and legal dilemmas]. Ces Gynek, 2004, 69, p. 335-339.

9. Dostal, J., Utrata, R., Loyka, S., et al. Post-mortem sperm retrieval in new European Union countries: case report. Hum Reprod, 2005, 20, p. 2359-2361.

10. Rivkees, SA., Crawford, JD. The relationship of gonadal activity and chemotherapy-induced gonadal damage. Jama, 1988, 259, p. 2123-2125.

11. Ward, JA., Robinson, J., Furr, BJ., et al. Protection of spermatogenesis in rats from the cytotoxic procarbazine by the depot formulation of Zoladex, a gonadotropin-releasing hormone agonist. Cancer Res, 1990, 50, p. 568-574.

12. Meistrich, ML., Wilson, G., Huhtaniemi, I. Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis. Cancer Res, 1999, 59, p. 3557-3560.

13. Thomson, AB., Anderson, RA., Irvine, DS., et al. Investigation of suppression of the hypothalamic-pituitary-gonadal axis to restore spermatogenesis in azoospermic men treated for childhood cancer. Human Reprod, 2002, 17, p. 1715-1723.

14. Greenlee, RT., Murray, T., Bolden, S., Wingo, PA. Cancer statistics, 2000. CA: a cancer journal for clinicians 2000, 50, p. 7-33.

15. Trounson, A., Mohr, L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature, 1983, 305, p. 707-709.

16. Ventruba, P., Zakova, J., Adler, J., et al. [Prolonged culture of human embryos: comparison of coculture on human tubal epithelium and culture in synthetic media]. Ces Gynek, 1996, 61, p. 351-357.

17. Ventruba, P., Mardesic, T., Pilka, L., et al. [The National Register for Assisted Reproduction: results and analysis of complications]. Ces Gynek, 1998, 63, p. 107-110.

18. Rezazadeh Valojerdi, M., Eftekhari-Yazdi, P., Karimian, L., et al. Vitrification versus slow freezing gives excellent survival, post warming embryo morphology and pregnancy outcomes for human cleaved embryos. J Assisted Reprod Genetics, 2009, 26, p. 347-354.

19. Katayama, KP., Stehlik, J., Kuwayama, M., et al. High survival rate of vitrified human oocytes results in clinical pregnancy. Fertil Steril, 2003, 80, p. 223-224.

20. Cobo, A., Bellver, J., Domingo, J., et al. New options in assisted reproduction technology: the Cryotop method of oocyte vitrification. Reprod Biomed online, 2008, 17, p. 68-72.

21. Cobo, A., Kuwayama, M., Perez, S., et al. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertil Steril, 2008, 89, p. 1657-1664.

22. Chian, RC., Huang, JY., Tan, SL., et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed online, 2008, 16, p. 608-610.

23. Ciotti, PM., Porcu, E., Notarangelo, L., et al. Meiotic spindle recovery is faster in vitrification of human oocytes compared to slow freezing. Fertil Steril, 2009, 91, p. 2399-2407.

24. Donnez, J., Dolmans, MM., Demylle, D., et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet, 2004, 364, p. 1405-1410.

25. Meirow, D., Levron, J., Eldar-Geva, T., et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med, 2005, 353, p. 318-321.

26. Demeestere, I., Simon, P., Buxant, F., et al. Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Human Reprod, 2006, 21, p. 2010-2014.

27. Hovatta, O. Methods for cryopreservation of human ovarian tissue. Reprod Biomed online, 2005, 10, p. 729-734.

28. Newton, H., Aubard, Y., Rutherford, A., et al. Low temperature storage and grafting of human ovarian tissue. Human Reprod, 1996, 11, p. 1487-1491.

29. Demeestere, I., Simon, P., Emiliani, S., et al. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. Oncologist, 2007, 12, p. 1437-1442.

30. Silber, SJ., DeRosa, M., Pineda, J., et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation and cryopreservation. Human Reprod, 2008, 23, p. 1531-1537.

31. Anderson, RA., Weddell, A., Spoudeas, HA., et al. Do doctors discuss fertility issues before they treat young patients with cancer? Human Reprod, 2008, 23, p. 2246-2251.

32. Donnez, J., Squifflet, J., Van Eyck, AS., et al. Restoration of ovarian function in orthotopically transplanted cryopreserved ovarian tissue: a pilot experience. Reprod Biomed online, 2008, 16, p. 694-704.

33. Wang, X., Chen, H., Yin, H., et al. Fertility after intact ovary transplantation. Nature, 2002, 415, p. 385.

34. Yin, H., Wang, X., Kim, SS., et al. Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype. Human Reprod, 2003, 18, p. 1165-1172.

35. Imhof, M., Bergmeister, H., Lipovac, M., et al. Orthotopic microvascular reanastomosis of whole cryopreserved ovine ovaries resulting in pregnancy and live birth. Fertil Steril, 2006, 85, Suppl 1, p. 1208-1215.

36. Arav, A., Revel, A., Nathan, Y., et al. Oocyte recovery, embryo development and ovarian function after cryopreservation and transplantation of whole sheep ovary. Human Reprod, 2005, 20, p. 3554-3559.

37. Martinez-Madrid, B., Dolmans, MM., Van Langendonckt, A., et al. Freeze-thawing intact human ovary with its vascular pedicle with a passive cooling device. Fertil Steril, 2004, 82, p. 1390-1394.

38. Dolmans, MM., Michaux, N., Camboni, A., et al. Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles. Human Reprod, 2006, 21, p. 413-420.

39. Xu, M., Barrett, SL., West-Farrell, E., et al. In vitro grown human ovarian follicles from cancer patients support oocyte growth. Human Reprod, 2009.

40. Kim, SS., Kang, HG., Kim, NH., et al. Assessment of the integrity of human oocytes retrieved from cryopreserved ovarian tissue after xenotransplantation. Human Reprod, 2005, 20, p. 2502-2508.

41. Morita, Y., Tilly, JL. Oocyte apoptosis: like sand through an hourglass. Developmental Biol, 1999, 213, p. 1-17.

42. Danforth, DR., Arbogast, LK., Ghosh, S., et al. Vascular endothelial growth factor stimulates preantral follicle growth in the rat ovary. Biol Reprod, 2003, 68, p. 1736-1741.

43. Blumenfeld, Z., Eckman, A. Preservation of fertility and ovarian function and minimization of chemotherapy-induced gonadotoxicity in young women by GnRH-a. J Natl Cancer Inst Monogr, 2005, p. 40-43.

44. Ataya, K., Rao, LV., Lawrence, E., Kimmel, R. Luteinizing hormone-releasing hormone agonist inhibits cyclophosphamide-induced ovarian follicular depletion in rhesus monkeys. Biol Reprod, 1995, 52, p. 365-372.

45. Blumenfeld, Z., Avivi, I., Linn, S., et al. Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy. Human Reprod, 1996, 11, p. 1620-1626.

46. Dann, EJ., Epelbaum, R., Avivi, I., et al. Fertility and ovarian function are preserved in women treated with an intensified regimen of cyclophosphamide, adriamycin, vincristine and prednisone (Mega-CHOP) for non-Hodgkin lymphoma. Human Reprod, 2005, 20, p. 2247-2249.

47. Recchia, F., Saggio, G., Amiconi, G., et al. Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma. Cancer, 2006, 106, p. 514‑523.

48. Badawy, A., Elnashar, A., El-Ashry, M., Shahat, M. Gonado­tropin-releasing hormone agonists for prevention of chemo­therapy-induced ovarian damage: prospective randomized study. Fertil Steril 2009, 91, p. 694-697.

49. Blumenfeld, Z., Avivi, I., Eckman, A., et al. Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma. Fertil Steril, 2008, 89, p. 166‑173.

50. Huser, M., Crha, I., Ventruba, P., et al. Prevention of ovarian function damage by a GnRH analogue during chemotherapy in Hodgkin lymphoma patients. Human Reprod, 2008, 23, p. 863‑868.

51. Blumenfeld, Z., von Wolff, M. GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy. Human Reprod update, 2008, 14, p. 543-552.

52. Ferme, C., Eghbali, H., Meerwaldt, JH., et al. Chemotherapy plus involved-field radiation in early-stage Hodgkin’s disease. N Engl J Med, 2007, 357, p. 1916-1927.

53. Requena, A., Herrero, J., Landeras, J., et al. Use of letrozole in assisted reproduction: a systematic review and meta-analysis. Human Reprod update, 2008, 14, p. 571-582.

54. Oktay, K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reprod update, 2001, 7, p. 526-534.

55. Bedaiwy, MA., El-Nashar, SA., El Saman, AM., et al. Reproductive outcome after transplantation of ovarian tissue: a systematic review. Human Reprod, 2008, 23, p. 2709-2717.

56. Huser, M., Crha, I., Hudecek, R., et al. Ovarian tissue cryopreservation. Eur J Gyn Oncol, 2007, 28, p. 249-255.

57. Huser, V., Narus, SP., Rocha, RA. Evaluation of a flowchart-based EHR query system: a case study of RetroGuide. J Biomed Informatics, 2010, 43, p. 41-50.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 2

2011 Issue 2

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#