Authors: K. Hurt; J. Šottner; J. Záhumenský; M. Halaška; M. Krčmář; A. Krajcová Authors‘ workplace: Halaška, DrSc. ; Gynekologicko-porodnická klinika 1. LF UK, Nemocnice na Bulovce, Praha, přednosta prof. MUDr. M. Published in: Ceska Gynekol 2006; 71(6): 499-501 Category: Original Article
Objective: The purpose of this article is to discuss the probable ways of interactions between some drugs or remedies and steroid contraceptives.
Design: A review article.
Setting: OBGYN Clinic of the 1st Faculty of Medicine, Prague, Teaching Hospital Bulovka.
Subject: Low dose oral contraceptives are very popular these days. Some drugs and remedies could negatively influence the levels of ethinyl estradiol (EE) and/or progestins and thus increase the possibility of their failure. These drugs mostly implicate as an inducer of the CYP450 system (liver) and as an inducer of P-glycoprotein transport system (transmembrane drug pump in the intestines). We wanted to describe briefly the mechanism and the principles of their impact.
Key words: oral contraceptives, interaction, drug, hormones, steroids
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