Determination of Cytokine Levels in Joint Fluid as an Alternative Option for Examination of Internal Temporomandibular Joint Disorders
Authors:
P. Tvrdý 1; P. Heinz 1; L. Hrdina 2; A. Galandáková 3; J. Pazdera 1
Authors‘ workplace:
Klinika ústní, čelistní a obličejové chirurgie LF UP a FN, Olomouc
1; Radiologická klinika LF UP a FN, Olomouc
2; Ústav lékařské chemie a biochemie LF UP, Olomouc
3
Published in:
Česká stomatologie / Praktické zubní lékařství, ročník 111, 2011, 4, s. 82-88
Category:
Original Article – Retrospective Essay
Overview
Cytokines are extracellular peptides that mediate the strong stimulatory or inhibitory effects on most biological cells. Originally they were considered as candidates for supporting processes of the immune response. It is now clear that they are involved in most physiological processes. They also act as mediators of infectious, inflammatory and immune diseases, including procurement related degenerative changes in tissues. Elevated level of interleukins IL-6, IL-1beta and IL-8 is directly linked to the pathogenesis of inflammatory and degenerative joint changes.
The authors presents a 10 patients pilot study of the use of determining the levels of selected interleukins IL-6 and IL-8 in the diagnosis of temporomandibular joint disorders. This examination can be supplemented with an algorithm established by clinical and imaging diagnostic methods and also to assess the efficacy of treatment.
Key words:
temporomandibular joint – diagnostic methods – arthrocentesis – interleukin 6 – interleukin 8
Sources
1. Alstergren, P.: Cytokines in temporomandibular joint arthritis. Oral Dis., roč. 6, 2000, č. 6, s. 331–334.
2. Arinci, A., Ademoglu, E., Aslan, A., Mutlu-Turkoglu, U., Karabulut, A. B., Karan, A.: Molecular correlates of temporomandibular joint disease. Oral Surg., Oral Med., Oral Pathol., Oral Radiol. Endod., roč. 99, 2005, č. 6, s. 666–670.
3. Bertram, S., Rudisch, A., Innerhofer, K., Pümpel, E., Grubwieser, G., Emshoff, R.: Diagnosing TMJ internal derangement and osteoarthritis with magnetic resonance imaging. J. Am. Dent. Assoc., roč. 132, 2001, č. 6, s. 753–761.
4. Emshoff, R., Puffer, P., Strobl, H., Gassner, R.: Effect of temporomandibular joint arthrocentesis on synovial fluid mediator level of tumor necrosis factor-alpha: implications for treatment outcome. Int. J. Oral Maxillofac. Surg., roč. 29, 2000, č. 3, s. 176–182.
5. Gulen, H., Ataoglu, H., Haliloglu, S., Isik, K.: Proinflammatory cytokines in temporomandibular joint synovial fluid before and after arthrocentesis. Oral Surg., Oral Med., Oral Pathol., Oral Radiol. Endod., roč. 107, 2009, č. 5, s. e1–e4.
6. Haskin, C. L., Milam, S. B., Cameron, I. L.: Pathogenesis of degenerative joint disease in the human temporomandibular joint. Crit. Rev. Oral Biol. Med., roč. 6, 1995, č. 3, s. 248–277.
7. Kaneyama, K., Segami, N., Sato, J., Nishimura, M., Yoshimura, H.: Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular point disorders. Br. J. Oral. Maxillofac. Surg., roč. 42, 2004, č. 3, s. 246–250.
8. Nishimura, M., Segami, N., Kaneyama, K., Sato, J., Fujimura, K.: Comparison of cytokine level in synovial fluid between successful and unsuccessful cases in arthrocentesis of the temporomandibular joint. J. Oral Maxillofac. Surg., roč. 62, 2004, č. 3, s. 284–287.
9. Sandler, N. A., Buckley, M. J., Cillo, J. E., Braun, T. W.: Correlation of inflammatory cytokines with arthroscopic findings in patients with temporomandibular joint internal derangements. J. Oral Maxillofac. Surg., roč. 56, 1998, č. 5, s. 534–543.
10. Sato, J., Segami, N., Nishimura, M., Demura, M.: Expression of interleukin 6 in synovial tissues in patients with internal derangement of the temporomandibular joint. Br. J. Oral Maxillofac. Surg., roč. 41, 2003, č. 2, s. 95–101.
11 Takahashi, T., Kondoh, T., Fukuda, M., Yamazaki, Y., Toyosaki, T., Suzuki, R.: Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. Oral Surg., Oral Med., Oral Pathol., Oral Radiol. Endod., roč. 85, 1998, č. 2, s. 135–141.
12. Tiilikainen, P., Pirttiniemi, P., Kainulainen, T., Pernu, H., Raustia, A.: MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement. J. Oral Pathol. Med., roč. 34, 2005, č. 1, s. 39–45.
13. Tvrdý, P., Pazdera, J.: Objektivní vyhodnocení léčby funkčních poruch temporomandibulárního kloubu pomocí fotoregistrace. Čes. Stomat., 2008, č. 6, s. 142–148.
Labels
Maxillofacial surgery Orthodontics Dental medicineArticle was published in
Czech Dental Journal
2011 Issue 4
Most read in this issue
- Cysts of Mandible and Maxilla. Etiology, Diagnostic Tools and Treatment Possibilities
- Burning Mouth Syndrome – The Most Common Causes of Our Patients
- Dental Erosions
- Evalutation of Antimicrobial Effect of Ozonated Water for Disinfection Dental Impressions