Malignant Lymphomas of Non-Hodgkin Type in the Annals of Stomatology Clinic in Hradec Králové 1998–2008
Authors:
V. Nováková 1; D. Belada 2; J. Laco 3; Petra Kašparová 3; M. Nová 3; R. Slezák 1
Authors‘ workplace:
Stomatologická klinika LF UK a FN, Hradec Králové
1; II. interní klinika - oddělení klinické hematologie LF UK a FN
Hradec Králové
2; Fingerlandův ústav patologie LF UK a FN, Hradec Králové
3
Published in:
Česká stomatologie / Praktické zubní lékařství, ročník 111, 2011, 2, s. 36-45
Category:
Original Article – Epidemiological Study
Overview
Introduction:
Malignant lymphomas of non-Hodgkin type (NHL) are the second most frequent malignant tumors in the head and neck area, although they represent only 2.2% of malignancies in this region and 2-3% of all NHL.
Objective:
the aim of the work was to analyze the problem of NHL from the standpoint of a stomatology clinical workplace.
Methods:
The review of available literature was at first devoted to analyze the problems in general. The actual retrospective study included 24 patients, who were diagnosed NHL in the period of January 1st 1998 to December 31st 2008 at our workplace. The follow up study concerned 22 individuals, while 13 of them had been treated by chemotherapy, 7 by immunotherapy, one by a combination of radiotherapy and chemotherapy and one by surgery. The median of observation was 52 months.
Results:
In 7 cases there was a nodal affection, 17 cases suffered from extranodal NHL (ENHL). In the ENHL group we encountered five times the affection of great salivary glands; the affection of alveolar process, buccal or vestibular mucosa and the buccal wall were represented evenly (three cases in all localizations); the roof of the mouth was affected in two cases and the tongue once. On the whole, 91.7% of the lymphomas were of B-cell origin. In the group of nodal lymphomas, the follicular lymphoma was most frequent (6 cases), in the ENHL group the follicular lymphoma was also most frequent (6 cases), followed by diffuse large cell B lymphoma (4 cases) and extranodal lymphoma from marginal zone (two cases). At the time of end of the observation (January 1st 2010), 71.4% patients of those we were in touch still lived.
Conclusion:
Early and rapid diagnosis of NHL can principally influence the prognosis of the disease quo ad vitam and it is therefore necessary to have this kind of malignant disease in mind even in the orofacial area.
Key words:
malignant lymphomas of the non-Hodgkin type, oral cavity, extranodal lymphomas, Sjögren syndrome
Sources
1. Bahnassy, A. A., Zekri, A. R. N., Asaad, N., El-Houssini, S., Khalid, H. M., Sedky, L. M., Mokhtar, N. M.: Epstein-Barr viral infection in extranodal lymphoma of the head and neck: Correlation with prognosis and response to treatment. Histopathology, roč. 48, 2006, s. 516-528.
2. Belada, D., Trněný, M. a kolektiv autorů: Kooperativní lymfomové skupiny: Diagnostické a léčebné postupy u nemocných s maligními lymfomy III. 4. vyd. Hradec Králové: HK CREDIT, s.r.o., 2009. 129 s. ISBN 978-80-86780-42-9.
3. Clarke, C. A., Glaser, S. L.: Changing incidence of non-Hodgkin’s lymphomas in the United States. Cancer, roč. 94, 2002, s. 2015-2023.
4. Ellis, G. L.: Lymphoid lesions of salivary glands: Malignant and benign. Med. Oral Pathol. Oral Cir. Bucal, roč. 12, 2007, č. 7, s. e479-e485.
5. Epstein, J. B., Epstein, J. D., Le, N. D., Gorsky, M.: Characteristics of oral and paraoral malignant lymphoma: A population-based review of 361 cases. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 92, 2001, s. 519-525.
6. Ezzat, A. A., Ibrahim, E. M., El Weshi, A. N., Khafaga, Y. M., AlJurf, M., Martin, J. M., Ajarim, D. S., Bazarbashi, S. N., Stuart, R. K., Zucca, E.: Localized non-Hodgkin’s lymphoma of Waldeyer’s ring: Clinical features, management, and prognosis of 130 adult patients. Head Neck, roč. 23, 2001, s. 547-558.
7. Groves, F. D., Linet, M. S., Travis, L. B., Devesa, S. S.: Cancer surveillance series: Non-Hodgkin’s lymphoma incidence by histologic subtype in the United States from 1978 through 1995. J. Natl. Cancer Inst., roč. 92, 2000, s. 1240-1251.
8. Kassan, S. S., Thomas, T. L., Moutsopoulos, H. M., Hoover, R., Kimberly, R. P., Budman, D. R. et al.: Increased risk of lymphoma in sicca syndrome. Ann. Intern. Med., roč. 89, 1978, s. 888-892.
9. Kemp, S., Gallagher, G., Kabani, S., Noonan, V., O’Hara, C.: Oral non-Hodgkin’s lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 105, 2008, s. 194-201.
10. Klener, P.: Non-hodgkinské lymfomy. In: Doporučené postupy pro praktické lékaře. Česká lékařská společnost J. E. Purkyně. Reg. č. a/030/100. Dostupné také na WWW: 11. Kolokotronis, A., Konstantinou, N., Christakis, I., Papadimitriou, P., Matiakis, A., Zaraboukas, T., Antoniades, D.: Localized B-cell non-Hodgkin’s lymphoma of oral cavity and maxillofacial region: A clinical study. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 99, 2005, s. 303-310.
12. Lacy, J.: Disorders of lymphocytes. In Andreaoli T. E., Carpenter, C. C. J., Griggs, R. C., Loscalzo, J. (ed.): Cecil Essentials of Medicine. 5. vydání. Philadelphia, W. B. Saunders Company, 2001, s. 435-448.
13. Laskar, S., Mohindra, P., Gupta, S., Shet, T., Muckaden, M. A.: Non-Hodgkin lymphoma of the Waldeyer’s ring: clinicopathologic and therapeutic issues. Leukemia Lymphoma, roč. 49, 2008, č. 12, s. 2263-2271.
14. Lazarus, M. N., Robinson, D., Mak, V., Moller, H., Isenberg, D. A.: Incidence of cancer in a cohort of patients with primary Sjögren’s syndrome. Rheumatology, roč. 45, 2006, s. 1012-1015.
15. Lima, I., Carneiro, A. S. B., Amorim, C. A., Santiago, M. B.: Hodgkin lymphoma as a complication of primary Sjögren’s syndrome. Mod. Rheumatol, roč. 18, 2008, s. 200-202.
16. Mawardi, H., Cutler, C., Treister, N.: Medical management update: Non-Hodgkin lymphoma. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 107, 2009, s. e19-e33.
17. Mottl, R., Laco, J., Belada, D., Týčová, V.: Difuzní B-velkobuněčný lymfom gingivy – popis případu. Lék. Zpr. LF UK Hradec Králové, roč. 52, 2007, č. 1, s. 47-52.
18. Ramos-Casals, M., García-Carrasco, M., Font, J., Cervera, R.: Sjögren’s syndrome and lymphoproliferative diseases. In: Shoenfeld, Y., Gershwin, E. M.: Cancer and autoimunity. Elsevier Science B.V., 2000, s. 55-80.
19. Solomides, C. C., Miller, A. S., Christman, R. A., Talwar, J., Simpkins, H.: Lymphomas of the oral cavity: Histology, immunologic type, and incidence of Epstein-Barr virus infection. Human Pathol, roč. 33, 2002, č. 2, s. 153-157.
20. Theander, E., Henriksson, G., Ljungberg, O., Mandl, T., Manthorpe, R., Jacobsson, L. T. H.: Lymphoma and other malignancies in primary Sjögren’s syndrome: a cohort study on cancer incidence and lymphoma predictors. Ann. Rheum. Dis., roč. 65, 2006, s. 796-803.
21. Trněný, M., Vášová, I., Pytlík, R., Belada, D. et al.: Distribuce podtypů non-Hodgkinského lymfomu v České republice a jejich přežití. Klinická onkologie, roč. 20, 2007, s. 340-348.
22. Urquhart, A., Berg, R.: Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck. Laryngoscope, roč. 111, 2001, s. 1565-1569.
23. Vega, F., Lin, P., Medeiros, L. J.: Extranodal lymphomas of the head and neck. Ann. Dian. Pathol., roč. 9, 2005, s. 340-350.
24. Vose, J. M., Chiu, B. C. H., Cheson, B. D., Dancey, J., Wright, J.: Update on epidemiology and therapeutics for non-Hodgkin’s lymphoma. Hematology Am. Soc. Hematom Educ. Program, 2002, s. 241-262.
25. Wu, X. C., Andrews, P., Chen, V. W., Groves, F.D.: Incidence of extranodal non-Hodgkin lymphomas among whites, blacks, and Asian/Pacific Islanders in the United States: Anatomic site and histology differences. Cancer Epidemiol, roč. 33, 2009, s. 337-346.
26. Zhang, W., Feng, S., Yan, S., Zhao, Y., Li, M., Sun, J., Zhang, F. C., Cui, Q., Dong, Y.: Incidence of malignancy in primary Sjögren’s syndrome in a Chinese cohort. Rheumatology, roč. 49, 2010, č. 3, s. 571-577.
27. Zintzaris, E., Voulgarelis, M., Moutsopoulos, H. M.: The risk of lymphoma development in autoimmune diseases: A meta-analysis. Arch. Intern. Med., roč. 165, 2005, s. 2337-2344.
Labels
Maxillofacial surgery Orthodontics Dental medicineArticle was published in
Czech Dental Journal
2011 Issue 2
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