Authors: M. Anders; Z. Fišar Authors‘ workplace: Psychiatrická klinika 1. LF UK a VFN, Praha přednosta prof. MUDr. J. Raboch, DrSc. Published in: Čes. a slov. Psychiat., 103, 2007, No. 8, pp. 408-412. Category: Comprehensive Reports
According to the membrane hypothesis of affective disorders, disturbances in lipid-protein interactions can be predisposing factor in depression. The hypothesis is based on well known fact that lipid-protein interactions affect functionality of most membrane integral proteins, including enzymes, receptors, transporters and ion channels ensuring transmembrane signal transduction. Moreover, changes in lipid-protein interactions induced by antidepressive drugs can be crucial step in molecular mechanism of their action.
Key words: membranes, depressive disorder, serotonin transporter, antidepressants.
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